| Tag | Content |
|---|---|
| Uniprot ID | A0A0G2K0K3 |
| Entrez ID | 360505 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_006246008.3 |
| Ensembl protein ID | ENSRNOP00000071482 |
| Ensembl nucleotide ID | ENSRNOG00000020541 |
| Gene name | NPR3-like, GATOR1 complex subunit |
| Gene symbol | Nprl3 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MGDNTSPISV ILVSSGSRGN KLLFRYPFQR SQEHPASQTN KPRSRYAVNN TGEHVDDQDG 60 DSSKPCPPTD EQLVAGFSDA ILATILATKS EMCGQKFELK IDNVRFVGHP TLLQHALGQV 120 SKTDPSPKRE APTMILFNVV FALRANADPS VINCLHTLSR RIATVLQHEE RRCQYLTREA 180 KLILALQDEV SAMADANEGP QSPFHHILPK CKLARDLKEA YDSLCTSGVV RLHINSWLEV 240 SFCLPHKIHY AASSLIPPEA IERSLKAIRP YHALLLLSDE KSLLSELPID CSPALVRVIK 300 TTSAVKNLQQ LAQDADLALL QVFQLAAHLV YWGKAVIIYP LCENNVYVLS PNASVCLYSP 360 LAEQFSRQFP SHDLPSVLAK FSLPVSLSEF RSPLAPPAQE TQLIQMVVWM LQRRLLIQLH 420 TYVCLMASPS EEEPRPREDD VPFTARVGGR SLSTPNALSF GSPTSSDDMT LTSPSMDNSS 480 AELLPSGDSP LNKRMTENLL ASLSEHERAA ILNVPAAQNP EDLRMFARLL HYFRGRHHLE 540 EIMYNENTRR SQLLMLFDKF RSVLVVTTHE DPVIAVFQAL LT 582 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | NPRL3 | 102185418 | A0A452EG12 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | NPRL3 | 8131 | Q12980 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Nprl3 | 17168 | Q8VIJ8 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | NPRL3 | A0A2I3SNN6 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | 100521441 | A0A4X1UMH2 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Nprl3 | 360505 | A0A0G2K0K3 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | nprl3 | F1QH43 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:1990130 | GATOR1 complex |
| GO:0005765 | lysosomal membrane |
| GO:0005096 | GTPase activator activity |
| GO:0035909 | aorta morphogenesis |
| GO:0048738 | cardiac muscle tissue development |
| GO:0034198 | cellular response to amino acid starvation |
| GO:0032007 | negative regulation of TOR signaling |
| GO:2000785 | regulation of autophagosome assembly |
| GO:0060021 | roof of mouth development |
| GO:0038202 | TORC1 signaling |
| GO:0003281 | ventricular septum development |
| Keyword ID | Keyword Term |
|---|---|
| KW-1185 | Reference proteome |
| InterPro ID | InterPro Term |
|---|---|
| IPR005365 | Npr3 |
| Pfam ID | Pfam Term |
|---|---|
| PF03666 | NPR3 |