| Tag | Content |
|---|---|
| Uniprot ID | A0A2I3SNN6 |
| Entrez ID | |
| Genbank protein ID | |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSPTRP00000078575 |
| Ensembl nucleotide ID | ENSPTRG00000007529 |
| Gene name | NPR3 like, GATOR1 complex subunit |
| Gene symbol | NPRL3 |
| Organism | Pan troglodytes |
| NCBI taxa ID | 9598 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | SPISVILVEL GEQGNKLLFI TPSREPGTPR SRYAASNTGD HADEQDGDSR FSDVILATIL 60 ATKSEMCGQK FELKIDNVRF VGHPTLLQHA LGQVSKTDPS PKREAPTMIL FNVVFALRAN 120 ADPSVINCLH NLSRRIATVL QHEERRCQYL TREAKLILAL QDEVSAMADG NEGPQSPFHH 180 ILPKCKLARD LKEAYDSLCT SGVVRLHINS WLEVSFCLPH KIHYAASSLI PPEAIERSLK 240 AIRPYHALLL LSDEKSLLGE LPIDCSPALV RVIKTTSAVK NLQQLAQDAD LALLQVFQLA 300 AHLVYWGKAI IIYPLCENNV YMLSPNASVC LYSPLAEQFS HQFPSHDLPS VLAKFSLPVS 360 LSEFRNPLAP AVQETQLIQM VVWMLQRRLL IQLHTYVCLM ASPSEEEPRP RDDDVPFTAR 420 VGGRSLSTPN ALSFGSPTSS DDMTLTSPSM DNSSAELLPS GDSPLNQRMT ENLLASLSEH 480 ERAAILSVPA AQNPEDLRMF ARLLHYFRGR HHLEEIMYNE NTRRSQLLML FDKFRSVLVV 540 TTHEDPVIAV FQALLP 556 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | NPRL3 | 102185418 | A0A452EG12 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | NPRL3 | 8131 | Q12980 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Nprl3 | 17168 | Q8VIJ8 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | NPRL3 | A0A2I3SNN6 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | 100521441 | A0A4X1UMH2 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Nprl3 | 360505 | A0A0G2K0K3 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | nprl3 | F1QH43 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:1990130 | GATOR1 complex |
| GO:0005765 | lysosomal membrane |
| GO:0005096 | GTPase activator activity |
| GO:0035909 | aorta morphogenesis |
| GO:0048738 | cardiac muscle tissue development |
| GO:0034198 | cellular response to amino acid starvation |
| GO:0032007 | negative regulation of TOR signaling |
| GO:2000785 | regulation of autophagosome assembly |
| GO:0060021 | roof of mouth development |
| GO:0038202 | TORC1 signaling |
| GO:0003281 | ventricular septum development |
| Keyword ID | Keyword Term |
|---|---|
| KW-1185 | Reference proteome |
| InterPro ID | InterPro Term |
|---|---|
| IPR005365 | Npr3 |
| Pfam ID | Pfam Term |
|---|---|
| PF03666 | NPR3 |