| Tag | Content |
|---|---|
| Uniprot ID | A0A0G2K970 |
| Entrez ID | |
| Genbank protein ID | |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSRNOP00000074882 |
| Ensembl nucleotide ID | ENSRNOG00000051965 |
| Gene name | Mothers against decapentaplegic homolog |
| Gene symbol | Smad4 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MDNMSITNTP TSNDACLSIV HSLMCHRQGG ESETFAKRAI ESLVKKLKEK KDELDSLITA 60 ITTNGAHPSK CVTIQRTLDG RLQVAGRKGF PHVIYARLWR WPDLHKNELK HVKYCQYAFD 120 LKCDSVCVNP YHYERVVSPG IDLSGLTLQS NAPPSMLVKD EYVHDFEGQP SLPTEGHSIQ 180 TIQHPPSNRA STETYSAPAL LAPSESNATS TTNFPNIPVA STSQPASILA GSHSEGLLQI 240 ASGPQPGQQQ NGFTAQPATY HHNSTTTWTG SRTAPYTPNL PHHQNGHLQH HPPMPPHPGH 300 YWPVHNELAF QPPISNHPAP EYWCSIAYFE MDVQVGETFK VPSSCPIVTV DGYVDPSGGD 360 RFCLGQLSNV HRTEAIERAR LHIGKGVQLE CKGEGDVWVR CLSDHAVFVQ SYYLDREAGR 420 APGDAVHKIY PSAYIKVFDL RQCHRQMQQQ AATAQAAAAA QAAAVAGNIP GPGSVGGIAP 480 AISLSCCCWH WCRRPPALVH TQDELREGLG PRLPRQSIKR TPCWIGFTST ELCSSWMKSC 540 TPCPLRTHSL |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | SMAD4 | 540248 | B0JYL0 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | SMAD4 | A0A5F4CED2 | Canis lupus familiaris | Prediction | More>> | |||
| 1:1 ortholog | SMAD4 | A0A452F8L3 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | SMAD4 | A0A3Q2GWH9 | Equus caballus | Prediction | More>> | |||
| 1:1 ortholog | SMAD4 | 4089 | Q13485 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Smad4 | 17128 | P97471 | CPO | E12.5, E13.5, E14.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | SMAD4 | A0A2I3S6S5 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | A0A4X1UID5 | Sus scrofa | Prediction | More>> | ||||
| 1:1 ortholog | SMAD4 | 100342294 | G1SKR1 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Smad4 | A0A0G2K970 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0032444 | activin responsive factor complex |
| GO:0005623 | cell |
| GO:0005813 | centrosome |
| GO:0005829 | cytosol |
| GO:0000790 | nuclear chromatin |
| GO:0005654 | nucleoplasm |
| GO:0071141 | SMAD protein complex |
| GO:0003682 | chromatin binding |
| GO:0005518 | collagen binding |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific |
| GO:0070411 | I-SMAD binding |
| GO:0098772 | molecular function regulator |
| GO:0042803 | protein homodimerization activity |
| GO:0070412 | R-SMAD binding |
| GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO:0001085 | RNA polymerase II transcription factor binding |
| GO:0043199 | sulfate binding |
| GO:0001223 | transcription coactivator binding |
| GO:0003712 | transcription coregulator activity |
| GO:0030616 | transforming growth factor beta receptor, common-partner cytoplasmic mediator activity |
| GO:0036302 | atrioventricular canal development |
| GO:0003190 | atrioventricular valve formation |
| GO:0007411 | axon guidance |
| GO:0030509 | BMP signaling pathway |
| GO:0003360 | brainstem development |
| GO:0001658 | branching involved in ureteric bud morphogenesis |
| GO:0008283 | cell population proliferation |
| GO:0006879 | cellular iron ion homeostasis |
| GO:0048589 | developmental growth |
| GO:0042733 | embryonic digit morphogenesis |
| GO:0060956 | endocardial cell differentiation |
| GO:0042118 | endothelial cell activation |
| GO:0003198 | epithelial to mesenchymal transition involved in endocardial cushion formation |
| GO:0061040 | female gonad morphogenesis |
| GO:0048859 | formation of anatomical boundary |
| GO:0001702 | gastrulation with mouth forming second |
| GO:0001701 | in utero embryonic development |
| GO:0070102 | interleukin-6-mediated signaling pathway |
| GO:0035556 | intracellular signal transduction |
| GO:0003220 | left ventricular cardiac muscle tissue morphogenesis |
| GO:0048382 | mesendoderm development |
| GO:0072133 | metanephric mesenchyme morphogenesis |
| GO:0010614 | negative regulation of cardiac muscle hypertrophy |
| GO:1905305 | negative regulation of cardiac myofibril assembly |
| GO:0060548 | negative regulation of cell death |
| GO:0030308 | negative regulation of cell growth |
| GO:0008285 | negative regulation of cell population proliferation |
| GO:0070373 | negative regulation of ERK1 and ERK2 cascade |
| GO:0000122 | negative regulation of transcription by RNA polymerase II |
| GO:0072134 | nephrogenic mesenchyme morphogenesis |
| GO:0014033 | neural crest cell differentiation |
| GO:0048663 | neuron fate commitment |
| GO:0003148 | outflow tract septum morphogenesis |
| GO:0001541 | ovarian follicle development |
| GO:0030513 | positive regulation of BMP signaling pathway |
| GO:0003251 | positive regulation of cell proliferation involved in heart valve morphogenesis |
| GO:0010718 | positive regulation of epithelial to mesenchymal transition |
| GO:0046881 | positive regulation of follicle-stimulating hormone secretion |
| GO:0051571 | positive regulation of histone H3-K4 methylation |
| GO:2000617 | positive regulation of histone H3-K9 acetylation |
| GO:0033686 | positive regulation of luteinizing hormone secretion |
| GO:0010862 | positive regulation of pathway-restricted SMAD protein phosphorylation |
| GO:0060391 | positive regulation of SMAD protein signal transduction |
| GO:0030511 | positive regulation of transforming growth factor beta receptor signaling pathway |
| GO:0061614 | pri-miRNA transcription by RNA polymerase II |
| GO:0051098 | regulation of binding |
| GO:0051797 | regulation of hair follicle development |
| GO:0032909 | regulation of transforming growth factor beta2 production |
| GO:0001666 | response to hypoxia |
| GO:0048733 | sebaceous gland development |
| GO:0062009 | secondary palate development |
| GO:0072520 | seminiferous tubule development |
| GO:0007338 | single fertilization |
| GO:0007183 | SMAD protein complex assembly |
| GO:0060395 | SMAD protein signal transduction |
| GO:0032525 | somite rostral/caudal axis specification |
| GO:0007283 | spermatogenesis |
| GO:0007179 | transforming growth factor beta receptor signaling pathway |
| GO:0060065 | uterus development |
| GO:0060412 | ventricular septum morphogenesis |