| Tag | Content |
|---|---|
| Uniprot ID | A0A2I3S6S5; A0A2J8NE28; |
| Entrez ID | |
| Genbank protein ID | |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSPTRP00000072257 |
| Ensembl nucleotide ID | ENSPTRG00000010028 |
| Gene name | Mothers against decapentaplegic homolog |
| Gene symbol | SMAD4 |
| Organism | Pan troglodytes |
| NCBI taxa ID | 9598 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MDNMSITNTP TSNDACLSIV HSLMCHRQGG ESETFAKRAI ESLVKKLKEK KDELDSLITA 60 ITTNGAHPSK CVTIQRTLDG RLQVAGRKGF PHVIYARLWR WPDLHKNELK HVKYCQYAFD 120 LKCDSVCVNP YHYERVVSPG IDLSGLTLQS NAPSSMMVKD EYVHDFEGQP SLSTEGHSIQ 180 TIQHPPSNRA STETYSTPAL LAPSESNATS TANFPNIPVA STTPEYWCSI AYFEMDVQVG 240 ETFKVPSSCP IVTVDGYVDP SGGDRFCLGQ LSNVHRTEAI ERARLHIGKG VQLECKGEGD 300 VWVRCLSDHA VFVQSYYLDR EAGRAPGDAV HKIYPSAYIK VFDLRQCHRQ MQQQAATAQA 360 AAAAQAAAVA GNIPGPGSVG GIAPAISLSA AAGIGVDDLR RLCILRMSFV KGWGPDYPRQ 420 SIKETPCWIE IHLHRALQLL DEVLHTMPIA DPQPLD 456 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | SMAD4 | 540248 | B0JYL0 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | SMAD4 | A0A5F4CED2 | Canis lupus familiaris | Prediction | More>> | |||
| 1:1 ortholog | SMAD4 | A0A452F8L3 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | SMAD4 | A0A3Q2GWH9 | Equus caballus | Prediction | More>> | |||
| 1:1 ortholog | SMAD4 | 4089 | Q13485 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Smad4 | 17128 | P97471 | CPO | E12.5, E13.5, E14.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | SMAD4 | A0A2I3S6S5 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | A0A4X1UID5 | Sus scrofa | Prediction | More>> | ||||
| 1:1 ortholog | SMAD4 | 100342294 | G1SKR1 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Smad4 | A0A0G2K970 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005737 | cytoplasm |
| GO:0005634 | nucleus |
| GO:0005667 | transcription factor complex |
| GO:0003677 | DNA binding |
| GO:0003700 | DNA-binding transcription factor activity |
| GO:0007179 | transforming growth factor beta receptor signaling pathway |