| Tag | Content |
|---|---|
| Uniprot ID | A0A5F4CED2 |
| Entrez ID | |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_005615393.2; XM_844277.5; XM_005615394.2; XM_014110418.1; |
| Ensembl protein ID | ENSCAFP00000052646 |
| Ensembl nucleotide ID | ENSCAFG00000000164 |
| Gene name | Mothers against decapentaplegic homolog |
| Gene symbol | SMAD4 |
| Organism | Canis lupus familiaris |
| NCBI taxa ID | 9615 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MDNMSITNTP TSNDACLSIV HSLMCHRQGG ESETFAKRAI ESLVKKLKEK KDELDSLITA 60 ITTNGAHPSK CVTIQRTLDG RLQVAGRKGF PHVIYARLWR WPDLHKNELK HVKYCQYAFD 120 LKCDSVCVNP YHYERVVSPG IDLSGLTLQS NAPPSMLVKD EYVHDFEGQP SLSTEGHSIQ 180 TIQHPPSNRA STETYSTPAL LAPSESNATS TTNFPNIPVA STSQPASILA GSHSEGLLQI 240 ASGPQPGQQQ NGFTAQPATY HHNSTTTWTG SRSAPYTPNL PHHQNGHLQH HPPMPPHPGH 300 YWPVHNELAF QPPISNHPAP EYWCSIAYFE MDVQVGETFK VPSSCPIVTV DGYVDPSGGD 360 RFCLGQLSNV HRTEAIERAR LHIGKGVQLE CKGEGDVWVR CLSDHAVFVQ SYYLDREAGR 420 APGDAVHKIY PSAYIKVFDL RQCHRQMQQQ AATAQAAAAA QAAAVAGNIP GPGSVGGIAP 480 AISLSAAAGI GVDDLRRLCI LRMSFVKGWG PDYPRQSIKE TPCWIEIHLH RALQLLDEVL 540 HTMPIADPQP LD 552 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | SMAD4 | 540248 | B0JYL0 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | SMAD4 | A0A5F4CED2 | Canis lupus familiaris | Prediction | More>> | |||
| 1:1 ortholog | SMAD4 | A0A452F8L3 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | SMAD4 | A0A3Q2GWH9 | Equus caballus | Prediction | More>> | |||
| 1:1 ortholog | SMAD4 | 4089 | Q13485 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Smad4 | 17128 | P97471 | CPO | E12.5, E13.5, E14.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | SMAD4 | A0A2I3S6S5 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | A0A4X1UID5 | Sus scrofa | Prediction | More>> | ||||
| 1:1 ortholog | SMAD4 | 100342294 | G1SKR1 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Smad4 | A0A0G2K970 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005737 | cytoplasm |
| GO:0005634 | nucleus |
| GO:0005667 | transcription factor complex |
| GO:0003677 | DNA binding |
| GO:0003700 | DNA-binding transcription factor activity |
| GO:0007179 | transforming growth factor beta receptor signaling pathway |