Gene: MAPK1

Basic information

Tag Content
Uniprot ID A0A2I3RP31
Entrez ID
Genbank protein ID
Genbank nucleotide ID
Ensembl protein ID ENSPTRP00000066088
Ensembl nucleotide ID ENSPTRG00000014120
Gene name Mitogen-activated protein kinase
Gene symbol MAPK1
Organism Pan troglodytes
NCBI taxa ID 9598
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MAAAAAAGAG PEMVRGQVFD VGPRYTNLSY IGEGAYGMVC SAYDNVNKVR VAIKKISPFE 60
HQTYCQRTLR EIKILLRFRH ENIIGINDII RAPTIEQMKD VYIVQDLMET DLYKLLKTQH 120
LSNDHICYFL YQILRGLKYI HSANVLHRDL KPSNLLLNTT CDLKICDFGL ARVADPDHDH 180
TGFLTEYVAT RWYRAPEIML NSKGYTKSID IWSVGCILAE MLSNRPIFPG KHYLDQLNHI 240
LGILGSPSQE DLNSRNYLLS LPHKNKVPWN RLFPNADSKA LDLLDKMLTF NPHKRIEVEQ 300
ALAHPYLEQY YDPSDEPIAE APFKFDMELD DLPKEKLKEL IFEETARFQP GYRS 354

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologMAPK1477575E2R2N2Canis lupus familiarisPredictionMore>>
1:1 orthologMAPK15594P28482Homo sapiensPredictionMore>>
1:1 orthologMapk126413P63085CPOE13.5, E14.5, E15.5, E16.5Mus musculusPublicationMore>>
1:1 orthologMAPK1A0A2I3RP31Pan troglodytesPredictionMore>>
1:1 orthologMapk1116590P63086Rattus norvegicusPredictionMore>>
1:1 orthologmapk1Q6P023Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005524 ATP binding
GO:0004707 MAP kinase activity

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0067 ATP-binding
KW-0418 Kinase
KW-0460 Magnesium
KW-0547 Nucleotide-binding
KW-1185 Reference proteome
KW-0723 Serine/threonine-protein kinase
KW-0808 Transferase

Interpro

InterPro ID InterPro Term
IPR011009 Kinase-like_dom_sf
IPR003527 MAP_kinase_CS
IPR008349 MAPK_ERK1/2
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS

PROSITE

PROSITE ID PROSITE Term
PS01351 MAPK
PS00107 PROTEIN_KINASE_ATP
PS50011 PROTEIN_KINASE_DOM
PS00108 PROTEIN_KINASE_ST

Pfam

Pfam ID Pfam Term
PF00069 Pkinase