Gene: mapk1

Basic information

Tag Content
Uniprot ID Q6P023; A0A0R4IHP1;
Entrez ID
Genbank protein ID AAH65868.1
Genbank nucleotide ID
Ensembl protein ID ENSDARP00000134234; ENSDARP00000123916; ENSDARP00000038550;
Ensembl nucleotide ID ENSDARG00000111915; ENSDARG00000027552;
Gene name Mitogen-activated protein kinase
Gene symbol mapk1
Organism Danio rerio
NCBI taxa ID 7955
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MATAAVSAPA GGGPNPGSGA EMVRGQAFDV GPRYSNLSYI GEGAYGMVCS AYDRDNKVRV 60
AIKKISPFEH QTYCQRTLRE IKILLRFKHE NIIGINDIIR TPTIDQMKDV YIVQDLMETD 120
LYKLLKTQHL SNDHICYFLY QILRGLKYIH SANVLHRDLK PSNLLLNTTC DLKICDFGLA 180
RVADPDHDHT GFLTEYVATR WYRAPEIMLN SKGYTKSIDI WSVGCILAEM LSNRPIFPGK 240
HYLDQLNHIL GILGSPSQED LNCIINIKAR NYLLSLPLRS KVPWNRLFPN ADPKALDLLD 300
KMLTFNPHKR IEVEEALAHP YLEQYYDPTD EPVAEAPFKF DMELDDLPKE TLKELIFEET 360
ARFQPGYRP 369

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologMAPK1477575E2R2N2Canis lupus familiarisPredictionMore>>
1:1 orthologMAPK15594P28482Homo sapiensPredictionMore>>
1:1 orthologMapk126413P63085CPOE13.5, E14.5, E15.5, E16.5Mus musculusPublicationMore>>
1:1 orthologMAPK1A0A2I3RP31Pan troglodytesPredictionMore>>
1:1 orthologMapk1116590P63086Rattus norvegicusPredictionMore>>
1:1 orthologmapk1Q6P023Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005737 cytoplasm
GO:0005634 nucleus
GO:0005524 ATP binding
GO:0004707 MAP kinase activity
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:0007166 cell surface receptor signaling pathway
GO:0007369 gastrulation
GO:0035556 intracellular signal transduction
GO:0010468 regulation of gene expression

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0067 ATP-binding
KW-0418 Kinase
KW-0460 Magnesium
KW-0547 Nucleotide-binding
KW-1267 Proteomics identification
KW-1185 Reference proteome
KW-0723 Serine/threonine-protein kinase
KW-0808 Transferase

Interpro

InterPro ID InterPro Term
IPR011009 Kinase-like_dom_sf
IPR003527 MAP_kinase_CS
IPR008349 MAPK_ERK1/2
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS

PROSITE

PROSITE ID PROSITE Term
PS01351 MAPK
PS00107 PROTEIN_KINASE_ATP
PS50011 PROTEIN_KINASE_DOM
PS00108 PROTEIN_KINASE_ST

Pfam

Pfam ID Pfam Term
PF00069 Pkinase