| Tag | Content |
|---|---|
| Uniprot ID | P63085; P27703; Q3V1U6; |
| Entrez ID | 26413 |
| Genbank protein ID | BAA01733.1; BAC29053.1; AAH58258.1; CAA41548.1; BAC40044.1; BAE21053.1; BAC33251.1; |
| Genbank nucleotide ID | NM_011949.3; XM_006522147.3; NM_001038663.1; |
| Ensembl protein ID | ENSMUSP00000111396; ENSMUSP00000156154; ENSMUSP00000065983; |
| Ensembl nucleotide ID | ENSMUSG00000063358 |
| Gene name | Mitogen-activated protein kinase 1 |
| Gene symbol | Mapk1 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | E13.5, E14.5, E15.5, E16.5 |
| Data sources | Manually collected |
| Reference | 18952847 |
| Functional description | Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation (such as EIF4EBP1) and a variety of other signaling-related molecules (like ARHGEF2, DCC, FRS2 or GRB10). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets, thereby extending the specificity of the cascade. Mediates phosphorylation of TPR in respons to EGF stimulation. May play a role in the spindle assembly checkpoint. Phosphorylates PML and promotes its interaction with PIN1, leading to PML degradation. Phosphorylates CDK2AP2 (By similarity). |
| Sequence | MAAAAAAGPE MVRGQVFDVG PRYTNLSYIG EGAYGMVCSA YDNLNKVRVA IKKISPFEHQ 60 TYCQRTLREI KILLRFRHEN IIGINDIIRA PTIEQMKDVY IVQDLMETDL YKLLKTQHLS 120 NDHICYFLYQ ILRGLKYIHS ANVLHRDLKP SNLLLNTTCD LKICDFGLAR VADPDHDHTG 180 FLTEYVATRW YRAPEIMLNS KGYTKSIDIW SVGCILAEML SNRPIFPGKH YLDQLNHILG 240 ILGSPSQEDL NCIINLKARN YLLSLPHKNK VPWNRLFPNA DSKALDLLDK MLTFNPHKRI 300 EVEQALAHPY LEQYYDPSDE PIAEAPFKFD MELDDLPKEK LKELIFEETA RFQPGYRS 358 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | MAPK1 | 477575 | E2R2N2 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | MAPK1 | 5594 | P28482 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Mapk1 | 26413 | P63085 | CPO | E13.5, E14.5, E15.5, E16.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | MAPK1 | A0A2I3RP31 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | Mapk1 | 116590 | P63086 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | mapk1 | Q6P023 | Danio rerio | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0001784 | phosphotyrosine residue binding | IMP |
| GO:0003690 | double-stranded DNA binding | ISO |
| GO:0004672 | protein kinase activity | IDA |
| GO:0004674 | protein serine/threonine kinase activity | ISO |
| GO:0004674 | protein serine/threonine kinase activity | IDA |
| GO:0004707 | MAP kinase activity | ISO |
| GO:0004707 | MAP kinase activity | IMP |
| GO:0004707 | MAP kinase activity | IDA |
| GO:0004707 | MAP kinase activity | IBA |
| GO:0004708 | MAP kinase kinase activity | IMP |
| GO:0005515 | protein binding | IPI |
| GO:0005524 | ATP binding | ISO |
| GO:0008134 | transcription factor binding | ISO |
| GO:0008353 | RNA polymerase II CTD heptapeptide repeat kinase activity | IDA |
| GO:0016301 | kinase activity | IDA |
| GO:0019901 | protein kinase binding | ISO |
| GO:0019902 | phosphatase binding | ISO |
| GO:0019902 | phosphatase binding | IPI |
| GO:0031435 | mitogen-activated protein kinase kinase kinase binding | ISO |
| GO:0042802 | identical protein binding | ISO |
| GO:0042802 | identical protein binding | IPI |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000165 | MAPK cascade | ISO |
| GO:0000165 | MAPK cascade | IDA |
| GO:0000187 | activation of MAPK activity | IEA |
| GO:0006351 | transcription, DNA-templated | NAS |
| GO:0006468 | protein phosphorylation | ISO |
| GO:0006468 | protein phosphorylation | IDA |
| GO:0006468 | protein phosphorylation | IMP |
| GO:0006915 | apoptotic process | IEA |
| GO:0006974 | cellular response to DNA damage stimulus | IDA |
| GO:0007049 | cell cycle | IEA |
| GO:0007165 | signal transduction | ISO |
| GO:0007166 | cell surface receptor signaling pathway | IBA |
| GO:0007507 | heart development | IMP |
| GO:0007568 | aging | ISO |
| GO:0009636 | response to toxic substance | ISO |
| GO:0009887 | animal organ morphogenesis | IDA |
| GO:0010468 | regulation of gene expression | IBA |
| GO:0010628 | positive regulation of gene expression | ISO |
| GO:0010800 | positive regulation of peptidyl-threonine phosphorylation | ISO |
| GO:0014032 | neural crest cell development | IGI |
| GO:0015966 | diadenosine tetraphosphate biosynthetic process | ISO |
| GO:0018105 | peptidyl-serine phosphorylation | ISO |
| GO:0018105 | peptidyl-serine phosphorylation | IDA |
| GO:0018105 | peptidyl-serine phosphorylation | IMP |
| GO:0018107 | peptidyl-threonine phosphorylation | IDA |
| GO:0019233 | sensory perception of pain | ISO |
| GO:0019858 | cytosine metabolic process | IDA |
| GO:0030278 | regulation of ossification | IGI |
| GO:0030335 | positive regulation of cell migration | IEA |
| GO:0030641 | regulation of cellular pH | IMP |
| GO:0030878 | thyroid gland development | IGI |
| GO:0031647 | regulation of protein stability | ISS |
| GO:0031663 | lipopolysaccharide-mediated signaling pathway | IDA |
| GO:0032212 | positive regulation of telomere maintenance via telomerase | ISO |
| GO:0032496 | response to lipopolysaccharide | IDA |
| GO:0032872 | regulation of stress-activated MAPK cascade | TAS |
| GO:0033598 | mammary gland epithelial cell proliferation | IDA |
| GO:0034198 | cellular response to amino acid starvation | ISO |
| GO:0034614 | cellular response to reactive oxygen species | ISO |
| GO:0035094 | response to nicotine | ISO |
| GO:0035094 | response to nicotine | IGI |
| GO:0035556 | intracellular signal transduction | ISO |
| GO:0035556 | intracellular signal transduction | IBA |
| GO:0038127 | ERBB signaling pathway | ISO |
| GO:0042307 | positive regulation of protein import into nucleus | ISO |
| GO:0042473 | outer ear morphogenesis | IGI |
| GO:0043330 | response to exogenous dsRNA | IDA |
| GO:0043627 | response to estrogen | ISO |
| GO:0045596 | negative regulation of cell differentiation | IGI |
| GO:0045727 | positive regulation of translation | ISO |
| GO:0045893 | positive regulation of transcription, DNA-templated | ISO |
| GO:0046697 | decidualization | ISO |
| GO:0048538 | thymus development | IGI |
| GO:0050852 | T cell receptor signaling pathway | IDA |
| GO:0050853 | B cell receptor signaling pathway | IDA |
| GO:0051090 | regulation of DNA-binding transcription factor activity | NAS |
| GO:0051403 | stress-activated MAPK cascade | ISO |
| GO:0051493 | regulation of cytoskeleton organization | TAS |
| GO:0051973 | positive regulation of telomerase activity | ISO |
| GO:0060020 | Bergmann glial cell differentiation | IGI |
| GO:0060045 | positive regulation of cardiac muscle cell proliferation | ISO |
| GO:0060291 | long-term synaptic potentiation | IGI |
| GO:0060324 | face development | IGI |
| GO:0060324 | face development | IMP |
| GO:0060425 | lung morphogenesis | IGI |
| GO:0060440 | trachea formation | IGI |
| GO:0060716 | labyrinthine layer blood vessel development | IMP |
| GO:0061308 | cardiac neural crest cell development involved in heart development | IGI |
| GO:0070371 | ERK1 and ERK2 cascade | ISO |
| GO:0070371 | ERK1 and ERK2 cascade | IGI |
| GO:0070849 | response to epidermal growth factor | ISS |
| GO:0070849 | response to epidermal growth factor | ISO |
| GO:0071276 | cellular response to cadmium ion | ISO |
| GO:0071310 | cellular response to organic substance | ISO |
| GO:0071310 | cellular response to organic substance | IBA |
| GO:0071356 | cellular response to tumor necrosis factor | IGI |
| GO:0072584 | caveolin-mediated endocytosis | TAS |
| GO:0090170 | regulation of Golgi inheritance | TAS |
| GO:0097011 | cellular response to granulocyte macrophage colony-stimulating factor stimulus | IDA |
| GO:1903351 | cellular response to dopamine | ISO |
| GO:1904355 | positive regulation of telomere capping | ISO |
| GO:2000641 | regulation of early endosome to late endosome transport | TAS |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005623 | cell | IEA |
| GO:0005634 | nucleus | ISO |
| GO:0005634 | nucleus | IDA |
| GO:0005634 | nucleus | TAS |
| GO:0005634 | nucleus | IBA |
| GO:0005654 | nucleoplasm | ISO |
| GO:0005654 | nucleoplasm | TAS |
| GO:0005737 | cytoplasm | ISO |
| GO:0005737 | cytoplasm | IDA |
| GO:0005737 | cytoplasm | IBA |
| GO:0005739 | mitochondrion | IDA |
| GO:0005739 | mitochondrion | TAS |
| GO:0005769 | early endosome | TAS |
| GO:0005770 | late endosome | TAS |
| GO:0005794 | Golgi apparatus | TAS |
| GO:0005815 | microtubule organizing center | IEA |
| GO:0005829 | cytosol | ISO |
| GO:0005829 | cytosol | IDA |
| GO:0005829 | cytosol | TAS |
| GO:0005856 | cytoskeleton | TAS |
| GO:0005886 | plasma membrane | ISS |
| GO:0005886 | plasma membrane | ISO |
| GO:0005901 | caveola | ISS |
| GO:0005901 | caveola | ISO |
| GO:0005901 | caveola | TAS |
| GO:0005925 | focal adhesion | TAS |
| GO:0014069 | postsynaptic density | ISO |
| GO:0030424 | axon | ISO |
| GO:0031143 | pseudopodium | IDA |
| GO:0032839 | dendrite cytoplasm | ISO |
| GO:0032991 | protein-containing complex | ISO |
| GO:0043204 | perikaryon | ISO |
| GO:0072686 | mitotic spindle | ISS |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-109582 | Hemostasis | IEA |
| R-MMU-111885 | Opioid Signalling | IEA |
| R-MMU-111995 | phospho-PLA2 pathway | IEA |
| R-MMU-111996 | Ca-dependent events | IEA |
| R-MMU-112040 | G-protein mediated events | IEA |
| R-MMU-112043 | PLC beta mediated events | IEA |
| R-MMU-112409 | RAF-independent MAPK1/3 activation | IEA |
| R-MMU-112411 | MAPK1 (ERK2) activation | IEA |
| R-MMU-1257604 | PIP3 activates AKT signaling | IEA |
| R-MMU-1266738 | Developmental Biology | IEA |
| R-MMU-1280215 | Cytokine Signaling in Immune system | IEA |
| R-MMU-1295596 | Spry regulation of FGF signaling | IEA |
| R-MMU-162582 | Signal Transduction | IEA |
| R-MMU-162658 | Golgi Cisternae Pericentriolar Stack Reorganization | IEA |
| R-MMU-1640170 | Cell Cycle | IEA |
| R-MMU-166016 | Toll Like Receptor 4 (TLR4) Cascade | IEA |
| R-MMU-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | IEA |
| R-MMU-166166 | MyD88-independent TLR4 cascade | IEA |
| R-MMU-166520 | Signaling by NTRKs | IEA |
| R-MMU-168138 | Toll Like Receptor 9 (TLR9) Cascade | IEA |
| R-MMU-168142 | Toll Like Receptor 10 (TLR10) Cascade | IEA |
| R-MMU-168164 | Toll Like Receptor 3 (TLR3) Cascade | IEA |
| R-MMU-168176 | Toll Like Receptor 5 (TLR5) Cascade | IEA |
| R-MMU-168179 | Toll Like Receptor TLR1:TLR2 Cascade | IEA |
| R-MMU-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | IEA |
| R-MMU-168188 | Toll Like Receptor TLR6:TLR2 Cascade | IEA |
| R-MMU-168249 | Innate Immune System | IEA |
| R-MMU-168256 | Immune System | IEA |
| R-MMU-168898 | Toll-like Receptor Cascades | IEA |
| R-MMU-169893 | Prolonged ERK activation events | IEA |
| R-MMU-170968 | Frs2-mediated activation | IEA |
| R-MMU-181438 | Toll Like Receptor 2 (TLR2) Cascade | IEA |
| R-MMU-187037 | Signaling by NTRK1 (TRKA) | IEA |
| R-MMU-187687 | Signalling to ERKs | IEA |
| R-MMU-190236 | Signaling by FGFR | IEA |
| R-MMU-194315 | Signaling by Rho GTPases | IEA |
| R-MMU-195258 | RHO GTPase Effectors | IEA |
| R-MMU-198725 | Nuclear Events (kinase and transcription factor activation) | IEA |
| R-MMU-198753 | ERK/MAPK targets | IEA |
| R-MMU-199418 | Negative regulation of the PI3K/AKT network | IEA |
| R-MMU-202670 | ERKs are inactivated | IEA |
| R-MMU-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | IEA |
| R-MMU-2029482 | Regulation of actin dynamics for phagocytic cup formation | IEA |
| R-MMU-2262752 | Cellular responses to stress | IEA |
| R-MMU-2454202 | Fc epsilon receptor (FCERI) signaling | IEA |
| R-MMU-2559580 | Oxidative Stress Induced Senescence | IEA |
| R-MMU-2559582 | Senescence-Associated Secretory Phenotype (SASP) | IEA |
| R-MMU-2559583 | Cellular Senescence | IEA |
| R-MMU-2559585 | Oncogene Induced Senescence | IEA |
| R-MMU-2871796 | FCERI mediated MAPK activation | IEA |
| R-MMU-3371453 | Regulation of HSF1-mediated heat shock response | IEA |
| R-MMU-3371556 | Cellular response to heat stress | IEA |
| R-MMU-372790 | Signaling by GPCR | IEA |
| R-MMU-373760 | L1CAM interactions | IEA |
| R-MMU-375165 | NCAM signaling for neurite out-growth | IEA |
| R-MMU-388396 | GPCR downstream signalling | IEA |
| R-MMU-416476 | G alpha (q) signalling events | IEA |
| R-MMU-418594 | G alpha (i) signalling events | IEA |
| R-MMU-422475 | Axon guidance | IEA |
| R-MMU-437239 | Recycling pathway of L1 | IEA |
| R-MMU-445144 | Signal transduction by L1 | IEA |
| R-MMU-448424 | Interleukin-17 signaling | IEA |
| R-MMU-449147 | Signaling by Interleukins | IEA |
| R-MMU-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | IEA |
| R-MMU-450294 | MAP kinase activation | IEA |
| R-MMU-450341 | Activation of the AP-1 family of transcription factors | IEA |
| R-MMU-456926 | Thrombin signalling through proteinase activated receptors (PARs) | IEA |
| R-MMU-5654726 | Negative regulation of FGFR1 signaling | IEA |
| R-MMU-5654727 | Negative regulation of FGFR2 signaling | IEA |
| R-MMU-5654732 | Negative regulation of FGFR3 signaling | IEA |
| R-MMU-5654733 | Negative regulation of FGFR4 signaling | IEA |
| R-MMU-5654736 | Signaling by FGFR1 | IEA |
| R-MMU-5654738 | Signaling by FGFR2 | IEA |
| R-MMU-5654741 | Signaling by FGFR3 | IEA |
| R-MMU-5654743 | Signaling by FGFR4 | IEA |
| R-MMU-5663213 | RHO GTPases Activate WASPs and WAVEs | IEA |
| R-MMU-5668599 | RHO GTPases Activate NADPH Oxidases | IEA |
| R-MMU-5673001 | RAF/MAP kinase cascade | IEA |
| R-MMU-5674135 | MAP2K and MAPK activation | IEA |
| R-MMU-5674499 | Negative feedback regulation of MAPK pathway | IEA |
| R-MMU-5675221 | Negative regulation of MAPK pathway | IEA |
| R-MMU-5683057 | MAPK family signaling cascades | IEA |
| R-MMU-5684996 | MAPK1/MAPK3 signaling | IEA |
| R-MMU-6798695 | Neutrophil degranulation | IEA |
| R-MMU-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | IEA |
| R-MMU-68875 | Mitotic Prophase | IEA |
| R-MMU-68886 | M Phase | IEA |
| R-MMU-69278 | Cell Cycle, Mitotic | IEA |
| R-MMU-74749 | Signal attenuation | IEA |
| R-MMU-74751 | Insulin receptor signalling cascade | IEA |
| R-MMU-74752 | Signaling by Insulin receptor | IEA |
| R-MMU-76002 | Platelet activation, signaling and aggregation | IEA |
| R-MMU-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | IEA |
| R-MMU-8939211 | ESR-mediated signaling | IEA |
| R-MMU-8953897 | Cellular responses to external stimuli | IEA |
| R-MMU-9006925 | Intracellular signaling by second messengers | IEA |
| R-MMU-9006931 | Signaling by Nuclear Receptors | IEA |
| R-MMU-9006934 | Signaling by Receptor Tyrosine Kinases | IEA |
| R-MMU-9009391 | Extra-nuclear estrogen signaling | IEA |
| R-MMU-937061 | TRIF(TICAM1)-mediated TLR4 signaling | IEA |
| R-MMU-9607240 | FLT3 Signaling | IEA |
| R-MMU-9634635 | Estrogen-stimulated signaling through PRKCZ | IEA |
| R-MMU-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | IEA |
| R-MMU-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | IEA |
| R-MMU-975155 | MyD88 dependent cascade initiated on endosome | IEA |
| R-MMU-975871 | MyD88 cascade initiated on plasma membrane | IEA |
| R-MMU-982772 | Growth hormone receptor signaling | IEA |
| Keyword ID | Keyword Term |
|---|---|
| KW-0007 | Acetylation |
| KW-0053 | Apoptosis |
| KW-0067 | ATP-binding |
| KW-0131 | Cell cycle |
| KW-0963 | Cytoplasm |
| KW-0206 | Cytoskeleton |
| KW-0903 | Direct protein sequencing |
| KW-0418 | Kinase |
| KW-0472 | Membrane |
| KW-0547 | Nucleotide-binding |
| KW-0539 | Nucleus |
| KW-0597 | Phosphoprotein |
| KW-1185 | Reference proteome |
| KW-0723 | Serine/threonine-protein kinase |
| KW-0808 | Transferase |
| KW-0832 | Ubl conjugation |
| Pfam ID | Pfam Term |
|---|---|
| PF00069 | Pkinase |