| Tag | Content |
|---|---|
| Uniprot ID | E2R2N2 |
| Entrez ID | 477575 |
| Genbank protein ID | |
| Genbank nucleotide ID | NM_001110800.1 |
| Ensembl protein ID | ENSCAFP00000030998 |
| Ensembl nucleotide ID | ENSCAFG00000015421 |
| Gene name | Mitogen-activated protein kinase |
| Gene symbol | MAPK1 |
| Organism | Canis lupus familiaris |
| NCBI taxa ID | 9615 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MAAAAAAGAG PEMVRGQVFD VGPRYTNLSY IGEGAYGMVC SAYDNVNKVR VAIKKISPFE 60 HQTYCQRTLR EIKILLRFRH ENIIGINDII RAPTIEQMKD VYIVQDLMET DLYKLLKTQH 120 LSNDHICYFL YQILRGLKYI HSANVLHRDL KPSNLLLNTT CDLKICDFGL ARVADPDHDH 180 TGFLTEYVAT RWYRAPEIML NSKGYTKSID IWSVGCILAE MLSNRPIFPG KHYLDQLNHI 240 LGILGSPSQE DLNCIINLKA RNYLLSLPHK NKVPWNRLFP NADSKALDLL DKMLTFNPHK 300 RIEVEQALAH PYLEQYYDPS DEPIAEAPFK FDMELDDLPK EKLKELIFEE TARFQPGYRS 360 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | MAPK1 | 477575 | E2R2N2 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | MAPK1 | 5594 | P28482 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Mapk1 | 26413 | P63085 | CPO | E13.5, E14.5, E15.5, E16.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | MAPK1 | A0A2I3RP31 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | Mapk1 | 116590 | P63086 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | mapk1 | Q6P023 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005623 | cell |
| GO:0005737 | cytoplasm |
| GO:0005829 | cytosol |
| GO:0005739 | mitochondrion |
| GO:0005634 | nucleus |
| GO:0031143 | pseudopodium |
| GO:0005524 | ATP binding |
| GO:0042802 | identical protein binding |
| GO:0004707 | MAP kinase activity |
| GO:0004708 | MAP kinase kinase activity |
| GO:0019902 | phosphatase binding |
| GO:0001784 | phosphotyrosine residue binding |
| GO:0008353 | RNA polymerase II CTD heptapeptide repeat kinase activity |
| GO:0050853 | B cell receptor signaling pathway |
| GO:0060020 | Bergmann glial cell differentiation |
| GO:0061308 | cardiac neural crest cell development involved in heart development |
| GO:0007166 | cell surface receptor signaling pathway |
| GO:0034198 | cellular response to amino acid starvation |
| GO:0071276 | cellular response to cadmium ion |
| GO:0006974 | cellular response to DNA damage stimulus |
| GO:1903351 | cellular response to dopamine |
| GO:0097011 | cellular response to granulocyte macrophage colony-stimulating factor stimulus |
| GO:0071310 | cellular response to organic substance |
| GO:0034614 | cellular response to reactive oxygen species |
| GO:0071356 | cellular response to tumor necrosis factor |
| GO:0019858 | cytosine metabolic process |
| GO:0038127 | ERBB signaling pathway |
| GO:0070371 | ERK1 and ERK2 cascade |
| GO:0060324 | face development |
| GO:0035556 | intracellular signal transduction |
| GO:0060716 | labyrinthine layer blood vessel development |
| GO:0031663 | lipopolysaccharide-mediated signaling pathway |
| GO:0060291 | long-term synaptic potentiation |
| GO:0060425 | lung morphogenesis |
| GO:0033598 | mammary gland epithelial cell proliferation |
| GO:0045596 | negative regulation of cell differentiation |
| GO:0042473 | outer ear morphogenesis |
| GO:0018105 | peptidyl-serine phosphorylation |
| GO:0018107 | peptidyl-threonine phosphorylation |
| GO:0010628 | positive regulation of gene expression |
| GO:0010800 | positive regulation of peptidyl-threonine phosphorylation |
| GO:0051973 | positive regulation of telomerase activity |
| GO:1904355 | positive regulation of telomere capping |
| GO:0032212 | positive regulation of telomere maintenance via telomerase |
| GO:0030641 | regulation of cellular pH |
| GO:0010468 | regulation of gene expression |
| GO:0030278 | regulation of ossification |
| GO:0070849 | response to epidermal growth factor |
| GO:0043330 | response to exogenous dsRNA |
| GO:0035094 | response to nicotine |
| GO:0051403 | stress-activated MAPK cascade |
| GO:0050852 | T cell receptor signaling pathway |
| GO:0048538 | thymus development |
| GO:0030878 | thyroid gland development |
| GO:0060440 | trachea formation |
| Pfam ID | Pfam Term |
|---|---|
| PF00069 | Pkinase |