CleftGeneDB-Search

Gene: MAPK1

Basic information

Tag	Content
Uniprot ID	E2R2N2
Entrez ID	477575
Genbank protein ID
Genbank nucleotide ID	NM_001110800.1
Ensembl protein ID	ENSCAFP00000030998
Ensembl nucleotide ID	ENSCAFG00000015421
Gene name	Mitogen-activated protein kinase
Gene symbol	MAPK1
Organism	Canis lupus familiaris
NCBI taxa ID	9615
Cleft type
Developmental stage
Data sources	Homology search
Reference
Functional description
Sequence	MAAAAAAGAG PEMVRGQVFD VGPRYTNLSY IGEGAYGMVC SAYDNVNKVR VAIKKISPFE 60 HQTYCQRTLR EIKILLRFRH ENIIGINDII RAPTIEQMKD VYIVQDLMET DLYKLLKTQH 120 LSNDHICYFL YQILRGLKYI HSANVLHRDL KPSNLLLNTT CDLKICDFGL ARVADPDHDH 180 TGFLTEYVAT RWYRAPEIML NSKGYTKSID IWSVGCILAE MLSNRPIFPG KHYLDQLNHI 240 LGILGSPSQE DLNCIINLKA RNYLLSLPHK NKVPWNRLFP NADSKALDLL DKMLTFNPHK 300 RIEVEQALAH PYLEQYYDPS DEPIAEAPFK FDMELDDLPK EKLKELIFEE TARFQPGYRS 360

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

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Relation	Gene symbol	Entrez ID	UniProt ID	Cleft type	Developmental stage	Species	Evidence	Details
1:1 ortholog	Mapk1	26413	P63085	CPO	E13.5, E14.5, E15.5, E16.5	Mus musculus	Publication	More>>
1:1 ortholog	MAPK1	477575	E2R2N2			Canis lupus familiaris	Prediction	More>>
1:1 ortholog	MAPK1	5594	P28482			Homo sapiens	Prediction	More>>
1:1 ortholog	MAPK1		A0A2I3RP31			Pan troglodytes	Prediction	More>>
1:1 ortholog	Mapk1	116590	P63086			Rattus norvegicus	Prediction	More>>
1:1 ortholog	mapk1		Q6P023			Danio rerio	Prediction	More>>

Showing 1 to 6 of 6 entries

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Gene ontology

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GO ID	GO Term
GO:0001784	phosphotyrosine residue binding
GO:0004707	MAP kinase activity
GO:0004708	MAP kinase kinase activity
GO:0005524	ATP binding
GO:0005623	cell
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005829	cytosol
GO:0006974	cellular response to DNA damage stimulus
GO:0007166	cell surface receptor signaling pathway
GO:0008353	RNA polymerase II CTD heptapeptide repeat kinase activity
GO:0010468	regulation of gene expression
GO:0010628	positive regulation of gene expression
GO:0010800	positive regulation of peptidyl-threonine phosphorylation
GO:0018105	peptidyl-serine phosphorylation
GO:0018107	peptidyl-threonine phosphorylation
GO:0019858	cytosine metabolic process
GO:0019902	phosphatase binding
GO:0030278	regulation of ossification

Showing 1 to 20 of 55 entries

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Functional annotations

Keywords

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Keyword ID	Keyword Term
KW-0067	ATP-binding
KW-0418	Kinase
KW-0460	Magnesium
KW-0547	Nucleotide-binding
KW-0723	Serine/threonine-protein kinase
KW-0808	Transferase
KW-1185	Reference proteome