Gene: SUFU

Basic information

Tag Content
Uniprot ID A0A2I3RQE6; A0A2J8PCY7;
Entrez ID 450699
Genbank protein ID
Genbank nucleotide ID XM_016919244.1
Ensembl protein ID ENSPTRP00000066881
Ensembl nucleotide ID ENSPTRG00000002895
Gene name SUFU negative regulator of hedgehog signaling
Gene symbol SUFU
Organism Pan troglodytes
NCBI taxa ID 9598
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MAELRPSGAP GPTAPPAPGP TAPPAFASLF PPGLHAIYGE CRRLYPDQPN PLQVTAIVKY 60
WLGGPDPLDY VSMYRNVGSP SANIPEHWHY ISFGLSDLYG DNRVHEFTGT DGPSGFGFEL 120
TFRLKRETGE SAPPTWPAEL MQGLARYVFQ SENTFCSGDH VSWHSPLDNS ESRIQHMLLT 180
EDPQMQPVQT PFGVVTFLQI VGVCTEELHS AQQWNGQGIL ELLRTVPIAG GPWLITDMRR 240
GETIFEIDPH LQERVDKGIE TDGSNLSGVS AKCAWDDLSR PPEDDEDSRS ICIGTQPRRL 300
SGKDTEQIRE TLRRGLEINS KPVLPPINPQ RQNGLAHDRA PSRKDSLESD SSTAIIPHEL 360
IRTRQLESVH LKFNQESGAL IPLCLRGRLL HGRHFTYKSI TGDMAITFVS TGVEGAFATE 420
EHPYAAHGPW LQL 433

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologSUFU608531E2RAI7Canis lupus familiarisPredictionMore>>
1:1 orthologSUFU102181468A0A452FM19Capra hircusPredictionMore>>
1:1 orthologSUFU51684Q9UMX1Homo sapiensPredictionMore>>
1:1 orthologSufu24069Q9Z0P7CPOMus musculusPublicationMore>>
1:1 orthologSUFU450699A0A2I3RQE6Pan troglodytesPredictionMore>>
1:1 orthologSUFU100345361U3KN20Oryctolagus cuniculusPredictionMore>>
1:1 orthologSufu361769Q4V8C6Rattus norvegicusPredictionMore>>
1:1 orthologsufu100001615A9JRW8Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0008134 transcription factor binding

Functional annotations

Keywords

Keyword ID Keyword Term
KW-1185 Reference proteome

Interpro

InterPro ID InterPro Term
IPR020941 SUFU-like_domain
IPR024314 SUFU_C
IPR038489 SUFU_C_sf
IPR037181 SUFU_N
IPR007768 Suppressor_of_fused
IPR016591 Suppressor_of_fused_euk

PROSITE

PROSITE ID PROSITE Term

Pfam

Pfam ID Pfam Term
PF05076 SUFU
PF12470 SUFU_C