| Tag | Content |
|---|---|
| Uniprot ID | U3KN20 |
| Entrez ID | 100345361 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_017348523.1 |
| Ensembl protein ID | ENSOCUP00000026629 |
| Ensembl nucleotide ID | ENSOCUG00000005781 |
| Gene name | SUFU negative regulator of hedgehog signaling |
| Gene symbol | SUFU |
| Organism | Oryctolagus cuniculus |
| NCBI taxa ID | 9986 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MGAGTGRAGA PPPWSPRGPE AHSGRLRGGD GWGGRCTVRR RGAGPRCSPH CLGESHPPSP 60 PAGPSVLFPS SALPGSPSAL RAGMAELRPS GAPGPSAPPA PGPTAPPAFA SLFPPGLHAI 120 YGECRRLYPD QPNPLQVTAI VKYWLGGPDP LDYVSMYRNV GSPSANIPEH WHYVSFGLSD 180 LYGDNRVHEF TGTDGPSGFG FELTFRLKRE TGESAPPTWP AELMQGLARY VFQSENTFCS 240 GDHVSWHSPL DNSESRIQHM LLTEDPQMQP VQTPFGVVTF LQIVGVCTEE LHSAQQWNGQ 300 GILELLRTVP VAGRPWLITD MRRGETIFEI DLHLQERVDK GIETDGSNLS GVSAKCAWDD 360 LSRPPEDDED SRSICIGTQP RRLSGKDTEQ IRETLRRGLE INSKPVLPPI NPQRQNGLTH 420 DRAPCLPLSL MSCSGSRKDS LESDSSTAII PHELIRTRQL ESVHLKFNQE SGALIPLCLR 480 GRLLHGRHFT YKSITGDMAI TFVSTGVEGA FATEEHPYAA HGPWLQILLT EEFVEKMLED 540 LEDLTSPEEC KLPKEYSWPE KKLKVSILPD VVFDSPLH 578 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | SUFU | 608531 | E2RAI7 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | SUFU | 102181468 | A0A452FM19 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | SUFU | 51684 | Q9UMX1 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Sufu | 24069 | Q9Z0P7 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | SUFU | 450699 | A0A2I3RQE6 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | SUFU | 100345361 | U3KN20 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Sufu | 361769 | Q4V8C6 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | sufu | 100001615 | A9JRW8 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005929 | cilium |
| GO:0005737 | cytoplasm |
| GO:0005654 | nucleoplasm |
| GO:0008013 | beta-catenin binding |
| GO:0019901 | protein kinase binding |
| GO:0008134 | transcription factor binding |
| GO:0035904 | aorta development |
| GO:0060976 | coronary vasculature development |
| GO:0042994 | cytoplasmic sequestering of transcription factor |
| GO:0001947 | heart looping |
| GO:1901621 | negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning |
| GO:0000122 | negative regulation of transcription by RNA polymerase II |
| GO:2000059 | negative regulation of ubiquitin-dependent protein catabolic process |
| GO:0001843 | neural tube closure |
| GO:0043588 | skin development |
| GO:0021776 | smoothened signaling pathway involved in spinal cord motor neuron cell fate specification |
| GO:0021775 | smoothened signaling pathway involved in ventral spinal cord interneuron specification |
| GO:0003281 | ventricular septum development |
| Keyword ID | Keyword Term |
|---|---|
| KW-1185 | Reference proteome |