| Tag | Content |
|---|---|
| Uniprot ID | Q4V8C6 |
| Entrez ID | 361769 |
| Genbank protein ID | EDL94350.1; AAH97447.1; |
| Genbank nucleotide ID | NM_001024899.1 |
| Ensembl protein ID | ENSRNOP00000026987 |
| Ensembl nucleotide ID | ENSRNOG00000019807 |
| Gene name | Suppressor of fused homolog |
| Gene symbol | Sufu |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Negative regulator in the hedgehog signaling pathway. Down-regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of GLI3 (GLI3FL). GLI3FL is complexed with SUFU in the cytoplasm and is maintained in a neutral state. Without the Hh signal, the SUFU-GLI3 complex is recruited to cilia, leading to the efficient processing of GLI3FL into GLI3R. When Hh signaling is initiated, SUFU dissociates from GLI3FL and the latter translocates to the nucleus, where it is phosphorylated, destabilized, and converted to a transcriptional activator (GLI3A). |
| Sequence | MAELRPSVAP GPAAPPASGP SAPPAFASLF PPGLHAIYGE CRRLYPDQPN PLQVTAIVKY 60 WLGGPDPLDY VSMYRNMGSP SANIPEHWHY ISFGLSDLYG DNRVHEFTGT DGPSGFGFEL 120 TFRLKRETGE SAPPTWPAEL MQGLARYVFQ SENTFCSGDH VSWHSPLDNS ESRIQHMLLT 180 EDPQMQPVQT PFGVVTFLQI VGVCTEELHS AQQWNGQGIL ELLRTVPIAG GPWLITDMRR 240 GETIFEIDPH LQQERVDKGI ETDGSNLSGV SAKCAWDDLS RPPEDDEDSR SICLGTQPRR 300 LSGKDTEQIR ETLRRGLEIN SKPVLPPINS QRQNGLTYDR APSRKDSLGS DISTAVIPHE 360 LIRTRQLESV HLKFNQESGA LIPLCLRGRL LHGRHFTYKS ITGDMAITFV STGVEGAFAT 420 EEHPYAAHGP WLQILLTEEF VEKMLEDLED LTSPEEFKLP KEYSWPEKKL KVSILPDVVF 480 DSPLH 485 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | SUFU | 608531 | E2RAI7 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | SUFU | 102181468 | A0A452FM19 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | SUFU | 51684 | Q9UMX1 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Sufu | 24069 | Q9Z0P7 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | SUFU | 450699 | A0A2I3RQE6 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | SUFU | 100345361 | U3KN20 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Sufu | 361769 | Q4V8C6 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | sufu | 100001615 | A9JRW8 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005929 | cilium |
| GO:0005737 | cytoplasm |
| GO:0005654 | nucleoplasm |
| GO:0005634 | nucleus |
| GO:0008013 | beta-catenin binding |
| GO:0019901 | protein kinase binding |
| GO:0008134 | transcription factor binding |
| GO:0035904 | aorta development |
| GO:0060976 | coronary vasculature development |
| GO:0042994 | cytoplasmic sequestering of transcription factor |
| GO:0007368 | determination of left/right symmetry |
| GO:0001947 | heart looping |
| GO:0043433 | negative regulation of DNA-binding transcription factor activity |
| GO:0045879 | negative regulation of smoothened signaling pathway |
| GO:1901621 | negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning |
| GO:0000122 | negative regulation of transcription by RNA polymerase II |
| GO:2000059 | negative regulation of ubiquitin-dependent protein catabolic process |
| GO:0001843 | neural tube closure |
| GO:0043588 | skin development |
| GO:0007224 | smoothened signaling pathway |
| GO:0021776 | smoothened signaling pathway involved in spinal cord motor neuron cell fate specification |
| GO:0021775 | smoothened signaling pathway involved in ventral spinal cord interneuron specification |
| GO:0021513 | spinal cord dorsal/ventral patterning |
| GO:0003281 | ventricular septum development |