| Tag | Content |
|---|---|
| Uniprot ID | A0A2I3TRS7; A0A2J8M6X7; |
| Entrez ID | 457844 |
| Genbank protein ID | JAA32458.1; JAA20213.1; JAA09123.1; JAA44621.1; JAA44623.1; JAA44620.1; JAA44622.1; |
| Genbank nucleotide ID | XM_514294.6 |
| Ensembl protein ID | ENSPTRP00000091927 |
| Ensembl nucleotide ID | ENSPTRG00000002145 |
| Gene name | Methionine synthase |
| Gene symbol | MTR |
| Organism | Pan troglodytes |
| NCBI taxa ID | 9598 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. |
| Sequence | MSPALQDLSQ PEGLKKTLRD EIDAILQKRI MVLDGGMGTM IQREKLNEEH FRGQEFKDHA 60 RPLKGNNDIL SITQPDVIYQ IHKEYLLAGA DIIETNTFSS TSIAQADYGL EHLAYRMNMC 120 SAGVARKAAE EVTLQTGIKR FVAGALGPTN KTLSVSPSVE RPDYRNITFD ELVEAYQEQA 180 KGLLDGGVDI LLIETIFDTA NAKAALFALQ NLFEEKYAPR PIFISGTIVD KSGRTLSGQT 240 GEGFVISVSH GEPLCIGLNC ALGAAEMRPF IEIIGKCTTA YVLCYPNAGL PNTFGDYDET 300 PSMMAKHLKD FAMDGLVNIV GGCCGSTPDH IREIAEAVKN CKPRVPPATA FEGHMLLSGL 360 EPFRIGPYTN FVNIGERCNV AGSRKFAKLI MAGNYEEALC VAKVQVEMGA QVLDVNMDDG 420 MLDGPSAMTR FCNLIASEPD IAKVPLCIDS SNFAVIEAGL KCCQGKCIVN SISLKEGEDD 480 FLEKARKIKK YGAAMVVMAF DEEGQATETD TKIRVCTRAY HLLVKKLGFN PNDIIFDPNI 540 LTIGTGMEEH NLYAINFIHA TKVIKETLPG ARISGGLSNL SFSFRGMEAI REAMHGVFLY 600 HAIKSGMDMG IVNAGNLPVY DDIHKELLQL CEDLIWNKDP EATEKLLRYA QTQGTGGKKV 660 IQTDEWRSGP VEERLEYALV KGIEKHIIED TEEARLNQKK YPRPLNIIEG PLMNGMKIVG 720 DLFGAGKMFL PQVIKSARVM KKAVGHLIPF MEKEREETRV LNGTVEEEDP YQGTIVLATV 780 KGDVHDIGKN IVGVVLGCNN FRVIDLGVMT PCDKILKAAL DHKADIIGLS GLITPSLDEM 840 IFVAKEMERL AIRIPLLIGG ATTSKTHTAV KIAPRYSAPV IHVLDASKSV VVCSQLLDEN 900 LKDEYFEEIM EEYEDIRQDH YESLKERRYL PLSQARKSGF QMDWLSEPHP VKPTFIGTQV 960 FEDYDLQKLV DYIDWKPFFD VWQLRGKYPN RGFPKIFNDK TVGGEARKVY DDAHNMLNTL 1020 ISQKKLRARG VVGFWPAQSI QDDIHLYAEA AVPQAAEPIA TFYGLRQQAE KDSASTEPYY 1080 CLSDFIAPLH SGIRDYLGLF AVACFGVEEL SKAYEDDGDD YSSIMVKALG DRLAEAFAEE 1140 LHERVRRELW AYCGSEQLDV ADLRRLRYKG IRPAPGYPSQ PDHTEKLTMW RLADIEQSTG 1200 IRLTESLAMA PASAVSGLYF SNLKSKYFAV GKISKDQVED YALRKNISVA EVEKWLGPIL 1260 GYDTD 1265 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | MTR | A0A3Q1M346 | Bos taurus | Prediction | More>> | |||
| 1:1 ortholog | MTR | 102172599 | A0A452DLF5 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | MTR | 4548 | Q99707 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Mtr | 238505 | A6H5Y3 | Mus musculus | Prediction | More>> | ||
| 1:1 ortholog | MTR | 457844 | A0A2I3TRS7 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | A0A480IS22 | Sus scrofa | Prediction | More>> | ||||
| 1:1 ortholog | Mtr | G3V8A4 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0031419 | cobalamin binding |
| GO:0008705 | methionine synthase activity |
| GO:0008270 | zinc ion binding |
| GO:0032259 | methylation |
| GO:0042558 | pteridine-containing compound metabolic process |
| InterPro ID | InterPro Term |
|---|---|
| IPR003759 | Cbl-bd_cap |
| IPR006158 | Cobalamin-bd |
| IPR036724 | Cobalamin-bd_sf |
| IPR011005 | Dihydropteroate_synth-like |
| IPR003726 | HCY_dom |
| IPR036589 | HCY_dom_sf |
| IPR033706 | Met_synthase_B12-bd |
| IPR011822 | MetH |
| IPR036594 | Meth_synthase_dom |
| IPR000489 | Pterin-binding_dom |
| IPR004223 | VitB12-dep_Met_synth_activ_dom |
| IPR037010 | VitB12-dep_Met_synth_activ_sf |