| Tag | Content |
|---|---|
| Uniprot ID | A0A480IS22 |
| Entrez ID | |
| Genbank protein ID | HDA39362.1; HCZ95106.1; HDA39361.1; HDA51384.1; HDA39357.1; HDA39360.1; HDB96627.1; HDA39359.1; HDA35840.1; HDA29570.1; HDC43955.1; HDA39358.1; HDA39363.1; |
| Genbank nucleotide ID | |
| Ensembl protein ID | |
| Ensembl nucleotide ID | |
| Gene name | Methionine synthase |
| Gene symbol | |
| Organism | Sus scrofa |
| NCBI taxa ID | 9823 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. |
| Sequence | MSPALQDLPQ AGMKKTLQDD IEAILQERIM VLDGGMGTMI QRHKLSEDDF RGQEFQDHAR 60 PLKGNNDILS ITQPDIIYQI HKDYLLAGAD IIETNTFSST NIAQADYGLE HLAYRMNKCS 120 AGVARKAAEE ISLQTGIKRF VAGALGPTNK TLSVSPSVEK PDYRNITFDE LVEAYKEQAK 180 GLLDGGVDIL LIETIFDTAN AKAALFAVQK LFEEEYAPRP IFISGTIVDK SGRTLSGQTG 240 EAFVISVSHA DPLCIGLNCA LGAAEMRPFI ETIGKCTTAY VLCYPNAGLP NTFGDYDETP 300 HMMAMHLKDF ATDGLVNIVG GCCGTTPAHI REIAEAVKNY KPRVPPATVF EGHMLLSGLE 360 PFRIGPYTNF VNIGERCNVA GSRKFAKLIM EGKYEEALSV AKMQVEMGAQ VLDINMDDGM 420 LDGPSAMARF CNFIASEPDI AKVPLCIDSS NFAVIEAGLK CCQGKCIVNS ISLKEGEDDF 480 LEKARRVKKF GAAVVVMAFD EEGQATETDT KIRVCTRAYH LLVNKLSFNP NDIIFDPNIL 540 TIGTGMEEHS LYAVNFIYAT KVIKETLPGA KVSGGLSNLS FSFRGMEAIR EAMHGVFLYH 600 AIQFGMDMGI VNAGSLPVYD DIHKELLQLC EDLIWNKDPE ATEKLLRYAQ TQGKGGKKVI 660 QTDEWRNGPI EERLEYALVK GIEKYIIEDT EEARLNQEKY PRPLNIIEGP LMNGMKIVGD 720 LFGAGKMFLP QVIKSARVMK KAVGHLIPFM EKEREENQVL TGIVEDEDPY QGTIVLATVK 780 GDVHDIGKNI VGVVLGCNNF RVIDLGVMTP CDKILKAALD HKADIIGLSG LITPSLDEMI 840 FVAKEMERLA IKIPLLIGGA TTSRTHTAVK IAPRYSAPVI HVLDASKSVV VCSQLLDENL 900 KDEYFEEIME EYEDIRQDHY ESLKERRYLT LRQAREKGFH IDWLSEPHPV KPTFLGTRVF 960 EDYDLQKLVD YIDWKPFFDV WQLRGKYPNR GFPKIFNDKT IGEEAKKVYD DAQNMLQELI 1020 SQKKLQARGV VGFWPAQSVE DDIHLYAEGT VPQAAEPIAT FYGLRQQAEK DSASTDPYLC 1080 LSDFIAPLHS GVPDYLGLFA VACFGVEELS KAYEAECDDY SIIMVKALGD RLAEAFAEEL 1140 HERVRKELWG YCGGEQLAVA DLRRLRFEGI RPAPGYPSQP DHTEKLTMWK LADVERLTGI 1200 RLTESLAMAP ASAVSGLYFS NVKSKYFAVG KISKDQIEDY ALRKNMTVAE VEKWLGPILG 1260 YDTD 1264 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | MTR | A0A3Q1M346 | Bos taurus | Prediction | More>> | |||
| 1:1 ortholog | MTR | 102172599 | A0A452DLF5 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | MTR | 4548 | Q99707 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Mtr | 238505 | A6H5Y3 | Mus musculus | Prediction | More>> | ||
| 1:1 ortholog | MTR | 457844 | A0A2I3TRS7 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | A0A480IS22 | Sus scrofa | Prediction | More>> | ||||
| 1:1 ortholog | Mtr | G3V8A4 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0031419 | cobalamin binding |
| GO:0008705 | methionine synthase activity |
| GO:0008270 | zinc ion binding |
| GO:0032259 | methylation |
| GO:0042558 | pteridine-containing compound metabolic process |
| InterPro ID | InterPro Term |
|---|---|
| IPR003759 | Cbl-bd_cap |
| IPR006158 | Cobalamin-bd |
| IPR036724 | Cobalamin-bd_sf |
| IPR011005 | Dihydropteroate_synth-like |
| IPR003726 | HCY_dom |
| IPR036589 | HCY_dom_sf |
| IPR033706 | Met_synthase_B12-bd |
| IPR011822 | MetH |
| IPR036594 | Meth_synthase_dom |
| IPR000489 | Pterin-binding_dom |
| IPR004223 | VitB12-dep_Met_synth_activ_dom |
| IPR037010 | VitB12-dep_Met_synth_activ_sf |