| Tag | Content |
|---|---|
| Uniprot ID | A0A452DLF5 |
| Entrez ID | 102172599 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_018042441.1 |
| Ensembl protein ID | ENSCHIP00000000458 |
| Ensembl nucleotide ID | ENSCHIG00000000324 |
| Gene name | Methionine synthase |
| Gene symbol | MTR |
| Organism | Capra hircus |
| NCBI taxa ID | 9925 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. |
| Sequence | MAPTLQDLTP SAGMEKTLQD EIEAILRERI MVLDGGMGTM IQRHKLSEED FRGQEFKDHA 60 RALKGNNDIL SITQPNVIYQ IHKDYLLAGA DIIETNTFSS TAIAQADYGL EHLAYRMNMC 120 SAGVARRAAE EVTLQTGIKR YVAGALGPTN KTLSVSPSVE RPDYRNITFD ELVEAYKEQA 180 KGLLDGGVDI LLIETIFDTA NAKAALFAVQ KLFEKEYVPR PVFISGTIVD KSGRTLSGQT 240 GEAFVISVSH ADPLCIGLNC ALGAAEMRPF IETIGKCTTA YVLCYPNAGL PNTFGDYDET 300 PQMMAMHVKD FAVDGLVNIV GGCCGTTPDH IREIAEAVKN CKPRVPPASV FEGHMLLSGL 360 EPFRIGPYTN FVNIGERCNV AGSRRFAKLI MAGNYEEALS VAKMQVEMGA QVLDINMDDG 420 MLDGPSAMTR FCNFIASEPD IAKVPLCIDS SNFAVIEAGL KCCQGKCIVN SISLKEGEDD 480 FLEKARKIKK FGAAVVVMAF DEEGQATETD TKIRVCTRAY HLLVKKLGFN PNDIIFDPNI 540 LTIGTGMEEH NLYAVNFINA TKVIKETLPG AKVSGGLSNL SFSFRGMEAI REAMHGVFLY 600 HAIKFGMDMG IVNAGSLPVY DDIHKELLQL CEDLIWNRDP EATEKLLRYA QTQGKGGKKV 660 IQTDEWRNGP VEERLEYALV KGIEKYIIED TEEARLNQEQ YPRPLNIIEG PLMNGMKIVG 720 DLFGAGKMFL PQVIKSARVM KKAVGHLIPF MEKEREETKV LTGKIEDEDP YQGTIVLATV 780 KGDVHDIGKN IVGVVLGCNN FRVIDLGVMT PCDKILKAAL DHKADIIGLS GLITPSLDEM 840 IFVAKEMERL AIKIPLLIGG ATTSRTHTAV KIAPRYSAPV IHVLDASKSV VVCSQLLDEN 900 LKDEYFEEIL EEYEDIRQDH YESLKERRYL TLRQARENGF HIDWLSEPPP VKPTFLGTRV 960 FEDYDLQKLV DYIDWKPFFD VWQLRGKYPN RGFPKIFDDK TVGEEAKKVY DDAQSMLQAL 1020 ISQKKLQARG VVGFWPAQSL QDDIHLYAEG AVPQASEPIA TFYGLRQQAE KDSASSDPYL 1080 CLSDFVAPLH SGIPDYLGLF AVACFGVEEL SKAYEEECDD YSSIMVKALG DRLAEAFAEE 1140 LHERVRRELW GYCSGEQLAV ADLRRLRYEG IRPAPGYPSQ PDHTEKLTMW RLADVEQCTG 1200 IRLTESLAMA PASAVSGLYF SNLKSKYFAV GKISKDQIED YASRKNMSVS EVEKWLGPIL 1260 GYDTD 1265 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | MTR | A0A3Q1M346 | Bos taurus | Prediction | More>> | |||
| 1:1 ortholog | MTR | 102172599 | A0A452DLF5 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | MTR | 4548 | Q99707 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Mtr | 238505 | A6H5Y3 | Mus musculus | Prediction | More>> | ||
| 1:1 ortholog | MTR | 457844 | A0A2I3TRS7 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | A0A480IS22 | Sus scrofa | Prediction | More>> | ||||
| 1:1 ortholog | Mtr | G3V8A4 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005829 | cytosol |
| GO:0031419 | cobalamin binding |
| GO:0008705 | methionine synthase activity |
| GO:0008270 | zinc ion binding |
| GO:0009235 | cobalamin metabolic process |
| GO:0032259 | methylation |
| GO:0042558 | pteridine-containing compound metabolic process |
| InterPro ID | InterPro Term |
|---|---|
| IPR003759 | Cbl-bd_cap |
| IPR006158 | Cobalamin-bd |
| IPR036724 | Cobalamin-bd_sf |
| IPR011005 | Dihydropteroate_synth-like |
| IPR003726 | HCY_dom |
| IPR036589 | HCY_dom_sf |
| IPR033706 | Met_synthase_B12-bd |
| IPR011822 | MetH |
| IPR036594 | Meth_synthase_dom |
| IPR000489 | Pterin-binding_dom |
| IPR004223 | VitB12-dep_Met_synth_activ_dom |
| IPR037010 | VitB12-dep_Met_synth_activ_sf |