| Tag | Content |
|---|---|
| Uniprot ID | G3V8A4 |
| Entrez ID | |
| Genbank protein ID | EDM06981.1 |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSRNOP00000071254; ENSRNOP00000023973; |
| Ensembl nucleotide ID | ENSRNOG00000017593 |
| Gene name | Methionine synthase |
| Gene symbol | Mtr |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. |
| Sequence | MKKTLQDEIE AILRKRIMVL DGGMGTMIQR YKLSEENFQG QEFKDHSRPL KGNNDILSIT 60 QPDVIYQIHK EYLLAGADII ETNTFSSTSI AQADYGLEHL AYRMNKCSAD VARKAAEEIT 120 LQTGVKRFVA GSLGPTNKTL SVSPSVERPD YRNITFDELV EAYQEQAKGL LDGGVDILLI 180 ETIFDTANAK AALFALQKLF EENYASPRPI FISGTIVDKS GRTLSGQTGE AFVTSVSHSD 240 PLCIGLNCAL GAAEMRPFIE TIGKCTTAYV LCYPNAGLPN TFGDYDETPA MMAMHLKDFA 300 VDGLVNVVGG CCGSTPDHIR EIAEAVKNCK PRVPPDSVFE GHMLLSGLEP FRIGPYTNFV 360 NIGERCNVAG SKKFAKLIMA GNYEEALSVA KVQVEMGAQV LDINMDDGML DGPSAMTKFC 420 NFIASEPDIA KVPLCIDSSN FAVIEAGLKC CQGKCIVNSI SLKEGEEDFL EKARKIKKFG 480 AAVVVMAFDE EGQATETDVK VSVCTRAYHL LVEKVGFNPN DIIFDPNILT IGTGMEEHNL 540 YAINFIHATR VIKETLPGVR ISGGLSNLSF AFRGMDAIRE AMHGVFLYHA IKFGMDMGIV 600 NAGSLPVYDD IHKDLLQLCE DLIWNRDAEA TEKLLRYAQT HGKGGKKVIQ TDEWRNGSIE 660 ERLEYALVKG IEKHIVEDTE EARLNREKYP RPLNIIEGPL MNGMKVVGDL FGAGKMFLPQ 720 VIKSARVMKK AVGHLIPFME KEREEARVLN GSVEEEDPYQ GTIVLATVKG DVHDIGKNIV 780 GVVLGCNNFR VIDLGVMTPC DKILQAALDH KADIIGLSGL ITPSLDEMIF VAKEMERLAI 840 KIPLLIGGAT TSRTHTAVKI APRYSAPVIH VLDASKSVVV CSQLLDENLK DDYFEEILEE 900 YEDIRQDHYE SLKERKYLPL SQARKHSFHI DWLSEPHPVK PTFIGTQVFE DYNLQKLVDY 960 IDWKPFFDVW QLRGKYPNRG FPKIFNDKAV GEEARKVYED AQNMLNILIS RKKLRARGVV 1020 GFWPAQSVQD DIHLYAEGAV PQAAEPIATF YGLRQQAEKD SSSTDPYHCL SDFVAPLHSG 1080 VRDYLGLFAV ACFGVEELSK AYEDDGDDYS SIMVKALGDR LAEAFAEELH ERVRRELWAY 1140 CGSEQLGVTD LRKLRYEGIR PAPGYPSQPD HTEKLTMWRL ANIEQATGIR LTESLAMAPA 1200 SAVSGLYFSN VKSKYFAVGK ISKDQIEDYA LRKNMSVAEV EKWLGPILGY DTD 1253 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | MTR | A0A3Q1M346 | Bos taurus | Prediction | More>> | |||
| 1:1 ortholog | MTR | 102172599 | A0A452DLF5 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | MTR | 4548 | Q99707 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Mtr | 238505 | A6H5Y3 | Mus musculus | Prediction | More>> | ||
| 1:1 ortholog | MTR | 457844 | A0A2I3TRS7 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | A0A480IS22 | Sus scrofa | Prediction | More>> | ||||
| 1:1 ortholog | Mtr | G3V8A4 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005829 | cytosol |
| GO:0031419 | cobalamin binding |
| GO:0008705 | methionine synthase activity |
| GO:0008270 | zinc ion binding |
| GO:0031103 | axon regeneration |
| GO:0071732 | cellular response to nitric oxide |
| GO:0009235 | cobalamin metabolic process |
| GO:0006306 | DNA methylation |
| GO:0042558 | pteridine-containing compound metabolic process |
| GO:0048678 | response to axon injury |
| InterPro ID | InterPro Term |
|---|---|
| IPR003759 | Cbl-bd_cap |
| IPR006158 | Cobalamin-bd |
| IPR036724 | Cobalamin-bd_sf |
| IPR011005 | Dihydropteroate_synth-like |
| IPR003726 | HCY_dom |
| IPR036589 | HCY_dom_sf |
| IPR033706 | Met_synthase_B12-bd |
| IPR011822 | MetH |
| IPR036594 | Meth_synthase_dom |
| IPR000489 | Pterin-binding_dom |
| IPR004223 | VitB12-dep_Met_synth_activ_dom |
| IPR037010 | VitB12-dep_Met_synth_activ_sf |