Gene: PKP1

Basic information

Tag Content
Uniprot ID A0A2J8KHS3; H2Q0V7;
Entrez ID
Genbank protein ID
Genbank nucleotide ID
Ensembl protein ID ENSPTRP00000003063
Ensembl nucleotide ID ENSPTRG00000001831
Gene name Plakophilin 1
Gene symbol PKP1
Organism Pan troglodytes
NCBI taxa ID 9598
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MNHSPLKTAL AYECFQDQDN STLALPSDQK MKTGTSGRQR VQEQVMMTVK RQKSKSSQSS 60
TLSHSNRGSM YDGLADNYNY GTTSRSSYYS KFQAGNGSWG YPIYNGTLKR EPDNRRFSSY 120
SQMENWSRHY PRGSCNTTGA GSDICFMQKI KASRSEPDLY CDPRGTLRKG TLGSKGQKTT 180
QNRYSFYSTC SGQKAIKKCP VRPPSCASKQ DPVYIPPISC NKDLSFGHSR ASSKICSEDI 240
ECSGLTIPKA VQYLSSQDEK YQAIGAYYIQ HTCFQDESAK QQVYQLGGIC KLVDLLRSPN 300
QNVQQAAAGA LRNLVFRSTT NKLETRRQNG IREAVSLLRR TGNAEIQKQL TGLLWNLSST 360
DELKEELIAD ALPVLADRVI IPFSGWCDGN SNMSREVVDP EVFFNATGCL RKRLGMRELL 420
VLVPQRATSS RVNLSSADAG RQTMRNYSGL IDSLMAYVQN CVAASRCDDK SVENCMCVLH 480
NLSYRLDAEV PTRYRQLEYN ARNAYTEKSS TGCFSNKSDK MMNNNYDCPL PEEETNPKGS 540
GWLYHSDAIR TYLNLMGKSK KDATLEACAG ALQNLTASKG LMSSGMSQLI GLKEKGLPQI 600
ARLLQSGNSD VVRSGASLLS NMSRHPLLHR VMGNQVFPEV TRLLTSHTGN TSNSEDILSS 660
ACYTVRNLMA SQPQLAKQYF SSSMLNNIIN LCRSSASPKA AEAARLLLSD MWSSKELQGV 720
LRQQGFDRNM LGTLAGANSL RNFTSRF 747

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologPKP1A0A452FUQ9Capra hircusPredictionMore>>
1:1 orthologPKP15317Q13835Homo sapiensPublicationMore>>
1:1 orthologPkp118772P97350Mus musculusPredictionMore>>
1:1 orthologPKP1A0A2J8KHS3Pan troglodytesPredictionMore>>
1:1 orthologPKP1I3LGN8Sus scrofaPredictionMore>>
1:1 orthologPkp1304822D3ZY51Rattus norvegicusPredictionMore>>
1:1 orthologpkp1b797838E7FBR0Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0030057 desmosome
GO:1990124 messenger ribonucleoprotein complex
GO:0005654 nucleoplasm
GO:0005886 plasma membrane
GO:0005521 lamin binding
GO:0098609 cell-cell adhesion
GO:0045110 intermediate filament bundle assembly
GO:1902373 negative regulation of mRNA catabolic process

Functional annotations

Keywords

Keyword ID Keyword Term
KW-1185 Reference proteome

Interpro

InterPro ID InterPro Term
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR000225 Armadillo
IPR028432 Plakophilin-1
IPR028435 Plakophilin/d_Catenin

PROSITE

PROSITE ID PROSITE Term
PS50176 ARM_REPEAT

Pfam

Pfam ID Pfam Term
PF00514 Arm