Gene: EYA1

Basic information

Tag Content
Uniprot ID A0A2J8M9N5; H2QWA5;
Entrez ID 472789
Genbank protein ID
Genbank nucleotide ID XM_001164492.3
Ensembl protein ID ENSPTRP00000034805
Ensembl nucleotide ID ENSPTRG00000020337
Gene name Eyes absent homolog
Gene symbol EYA1
Organism Pan troglodytes
NCBI taxa ID 9598
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MEMQDLTSPH SRLSGSSESP SGPKLDNSHI NSNSMTPNGT EVKTEPMSSS ETASTTADGS 60
LDNFSGSAIG SSSFSPRPTH QFSPPQIYPS NRPYPHILPT PSSQTMAAYG QTQFTTGMQQ 120
ATAYATYPQP GQPYGISSYG ALWAGIKTEG GLSQSQSPGQ TGFLSYGTSF STPQPGQAPY 180
SYQMQGSSFT TSSGLYTGNN SLTNSSGFNS SQQDYPSYPS FGQGQYAQYY NSSPYPAHYM 240
TSSNTSPTTP STNATYQLQE PPSGITSQAV TDPTAEYSTI HSPSTPIKDS DSDRLRRGSD 300
GKSRGRGRRN NNPSPPPDSD LERVFIWDLD ETIIVFHSLL TGSYANRYGR DPPTSVSLGL 360
RMEEMIFNLA DTHLFFNDLE ECDQVHIDDV SSDDNGQDLS TYNFGTDGFP AAATSANLCL 420
ATGVRGGVDW MRKLAFRYRR VKEIYNTYKN NVGGLLGPAK REAWLQLRAE IEALTDSWLT 480
LALKALSLIH SRTNCVNILV TTTQLIPALA KVLLYGLGIV FPIENIYSAT KIGKESCFER 540
IIQRFGRKVV YVVIGDGVEE EQGAKKHAMP FWRISSHSDL MALHHALELE YL 592

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologEYA1477910A0A5F4BXU4Canis lupus familiarisPredictionMore>>
1:1 orthologEYA1102178462A0A452FKX1Capra hircusPredictionMore>>
1:1 orthologEYA12138Q99502CPO,CL/PHomo sapiensPublicationMore>>
1:1 orthologEya114048P97767CPOE13.5, E14.5Mus musculusPublicationMore>>
1:1 orthologEYA1472789A0A2J8M9N5Pan troglodytesPredictionMore>>
1:1 orthologEya1D3ZVI5Rattus norvegicusPredictionMore>>
1:1 orthologeya130436E9QJ32Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005737 cytoplasm
GO:0016604 nuclear body
GO:0032993 protein-DNA complex
GO:0046872 metal ion binding
GO:0004725 protein tyrosine phosphatase activity
GO:0003723 RNA binding
GO:0035909 aorta morphogenesis
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0090103 cochlea morphogenesis
GO:0006302 double-strand break repair
GO:0048704 embryonic skeletal system morphogenesis
GO:0016576 histone dephosphorylation
GO:0007501 mesodermal cell fate specification
GO:0001656 metanephros development
GO:0042474 middle ear morphogenesis
GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:0048665 neuron fate specification
GO:0071600 otic vesicle morphogenesis
GO:0042473 outer ear morphogenesis
GO:0003151 outflow tract morphogenesis
GO:0007389 pattern specification process
GO:0060037 pharyngeal system development
GO:0045739 positive regulation of DNA repair
GO:0050679 positive regulation of epithelial cell proliferation
GO:0072513 positive regulation of secondary heart field cardioblast proliferation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0016925 protein sumoylation
GO:0045664 regulation of neuron differentiation
GO:0010212 response to ionizing radiation
GO:0048752 semicircular canal morphogenesis
GO:0014706 striated muscle tissue development

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0378 Hydrolase
KW-0460 Magnesium
KW-0479 Metal-binding
KW-0904 Protein phosphatase
KW-1185 Reference proteome
KW-0804 Transcription
KW-0805 Transcription regulation

Interpro

InterPro ID InterPro Term
IPR006545 EYA_dom
IPR042577 EYA_dom_metazoan
IPR038102 EYA_dom_sf
IPR028472 EYA_fam
IPR028471 Eyes_absent_h1

PROSITE

PROSITE ID PROSITE Term

Pfam

Pfam ID Pfam Term