| Tag | Content |
|---|---|
| Uniprot ID | A0A2J8PZV0; H2Q4C4; |
| Entrez ID | 451401 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_016921532.1; XM_016921533.1; XM_016921535.1; XM_016921534.1; XM_016921536.1; |
| Ensembl protein ID | ENSPTRP00000006930 |
| Ensembl nucleotide ID | ENSPTRG00000004029 |
| Gene name | Folate receptor alpha |
| Gene symbol | FOLR1 |
| Organism | Pan troglodytes |
| NCBI taxa ID | 9598 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MAQRMTTQLL LLLVWVAVVG EAQTRIARAR TELLNVCMNA KHHKEKPGPE DKLHEQCRPW 60 RKNACCSTNT SQEAHKDVSY LYRFNWNHCG EMAPACKRHF IQDTCLYECS PNLGPWIQQV 120 DQSWRKERVL NVPLCKEDCE QWWEDCRTSY TCKSNWHKGW NWTSGFNNCP VGAACQPFHF 180 YFPTPTVLCN EIWTHSYKVS NYSRGSGRCI QMWFDPAQGN PNEEVARFYA AAMSGAGPWA 240 AWPFLLSLAL MLLWLLS 257 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | FOLR1 | 2348 | P15328 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Folr1 | 14275 | P35846 | CPO,CLP,CLO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | FOLR1 | 451401 | A0A2J8PZV0 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | FOLR1 | A0A287BP62 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | FOLR2 | 100342424 | G1SCR2 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Folr1 | 171049 | G3V8M6 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0031362 | anchored component of external side of plasma membrane |
| GO:0016324 | apical plasma membrane |
| GO:0016323 | basolateral plasma membrane |
| GO:0016021 | integral component of membrane |
| GO:0005634 | nucleus |
| GO:0005542 | folic acid binding |
| GO:0061714 | folic acid receptor activity |
| GO:0051870 | methotrexate binding |
| GO:0061713 | anterior neural tube closure |
| GO:0031103 | axon regeneration |
| GO:0003253 | cardiac neural crest cell migration involved in outflow tract morphogenesis |
| GO:1904447 | folate import across plasma membrane |
| GO:0046655 | folic acid metabolic process |
| GO:0001947 | heart looping |
| GO:0003147 | neural crest cell migration involved in heart formation |
| GO:0061626 | pharyngeal arch artery morphogenesis |
| GO:0060828 | regulation of canonical Wnt signaling pathway |
| GO:0017015 | regulation of transforming growth factor beta receptor signaling pathway |
| Keyword ID | Keyword Term |
|---|---|
| KW-1185 | Reference proteome |
| Pfam ID | Pfam Term |
|---|---|
| PF03024 | Folate_rec |