| Tag | Content |
|---|---|
| Uniprot ID | P35846; Q9R222; |
| Entrez ID | 14275 |
| Genbank protein ID | AAD19353.1; EDL16537.1; AAA37596.1; EDL16532.1; AAA37595.1; EDL16530.1; AAI38796.1; EDL16533.1; EDL16538.1; AAI38782.1; AAA37598.1; EDL16536.1; EDL16535.1; EDL16534.1; AAI45415.1; |
| Genbank nucleotide ID | NM_001252553.1; XM_006507363.3; XM_006507368.3; NM_008034.3; XM_006507369.3; XM_006507365.3; XM_006507364.2; XM_006507360.3; NM_001252554.1; XM_006507366.2; XM_006507361.2; XM_006507367.3; NM_001252552.1; XM_006507370.3; |
| Ensembl protein ID | ENSMUSP00000102594; ENSMUSP00000102595; ENSMUSP00000102598; ENSMUSP00000102599; ENSMUSP00000102596; |
| Ensembl nucleotide ID | ENSMUSG00000001827 |
| Gene name | Folate receptor alpha |
| Gene symbol | Folr1 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO,CLP,CLO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 12854656 |
| Functional description | Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation. Required for renal folate reabsorption. |
| Sequence | MAHLMTVQLL LLVMWMAECA QSRATRARTE LLNVCMDAKH HKEKPGPEDN LHDQCSPWKT 60 NSCCSTNTSQ EAHKDISYLY RFNWNHCGTM TSECKRHFIQ DTCLYECSPN LGPWIQQVDQ 120 SWRKERILDV PLCKEDCQQW WEDCQSSFTC KSNWHKGWNW SSGHNECPVG ASCHPFTFYF 180 PTSAALCEEI WSHSYKLSNY SRGSGRCIQM WFDPAQGNPN EEVARFYAEA MSGAGFHGTW 240 PLLCSLSLVL LWVIS 255 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | FOLR1 | 2348 | P15328 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Folr1 | 14275 | P35846 | CPO,CLP,CLO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | FOLR1 | 451401 | A0A2J8PZV0 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | FOLR1 | A0A287BP62 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | FOLR2 | 100342424 | G1SCR2 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Folr1 | 171049 | G3V8M6 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005542 | folic acid binding | ISS |
| GO:0005542 | folic acid binding | ISO |
| GO:0005542 | folic acid binding | TAS |
| GO:0008144 | drug binding | ISO |
| GO:0038023 | signaling receptor activity | TAS |
| GO:0038023 | signaling receptor activity | IBA |
| GO:0051870 | methotrexate binding | ISO |
| GO:0061714 | folic acid receptor activity | ISS |
| GO:0061714 | folic acid receptor activity | ISO |
| GO:0061714 | folic acid receptor activity | TAS |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0001947 | heart looping | IMP |
| GO:0003147 | neural crest cell migration involved in heart formation | IMP |
| GO:0003253 | cardiac neural crest cell migration involved in outflow tract morphogenesis | IMP |
| GO:0006620 | posttranslational protein targeting to endoplasmic reticulum membrane | TAS |
| GO:0015884 | folic acid transport | ISS |
| GO:0015884 | folic acid transport | ISO |
| GO:0017015 | regulation of transforming growth factor beta receptor signaling pathway | IMP |
| GO:0031103 | axon regeneration | IMP |
| GO:0046655 | folic acid metabolic process | IMP |
| GO:0048678 | response to axon injury | IMP |
| GO:0060828 | regulation of canonical Wnt signaling pathway | IMP |
| GO:0061626 | pharyngeal arch artery morphogenesis | IMP |
| GO:0061713 | anterior neural tube closure | IMP |
| GO:0071231 | cellular response to folic acid | ISO |
| GO:1904447 | folate import across plasma membrane | IEA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005576 | extracellular region | IEA |
| GO:0005634 | nucleus | ISO |
| GO:0005768 | endosome | IEA |
| GO:0005903 | brush border | ISO |
| GO:0016020 | membrane | TAS |
| GO:0016323 | basolateral plasma membrane | ISO |
| GO:0016324 | apical plasma membrane | ISO |
| GO:0030136 | clathrin-coated vesicle | IEA |
| GO:0031362 | anchored component of external side of plasma membrane | ISS |
| GO:0031362 | anchored component of external side of plasma membrane | ISO |
| GO:0031362 | anchored component of external side of plasma membrane | IBA |
| GO:0031526 | brush border membrane | ISO |
| GO:0046658 | anchored component of plasma membrane | ISO |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-199977 | ER to Golgi Anterograde Transport | IEA |
| R-MMU-199991 | Membrane Trafficking | IEA |
| R-MMU-204005 | COPII-mediated vesicle transport | IEA |
| R-MMU-392499 | Metabolism of proteins | IEA |
| R-MMU-446203 | Asparagine N-linked glycosylation | IEA |
| R-MMU-5653656 | Vesicle-mediated transport | IEA |
| R-MMU-5694530 | Cargo concentration in the ER | IEA |
| R-MMU-597592 | Post-translational protein modification | IEA |
| R-MMU-6807878 | COPI-mediated anterograde transport | IEA |
| R-MMU-948021 | Transport to the Golgi and subsequent modification | IEA |
| Pfam ID | Pfam Term |
|---|---|
| PF03024 | Folate_rec |