Gene: KCNJ2

Basic information

Tag Content
Uniprot ID A0A452DN29
Entrez ID 102168940
Genbank protein ID
Genbank nucleotide ID XM_005694470.3
Ensembl protein ID ENSCHIP00000001168
Ensembl nucleotide ID ENSCHIG00000002047
Gene name Uncharacterized protein
Gene symbol KCNJ2
Organism Capra hircus
NCBI taxa ID 9925
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MGSVRTNRYS IVSSEEDGMK LATLAVANGF GNGKSKVHTR QQCRSRFVKK DGHCNVQFVN 60
VGEKGQRYLA DIFTTCVDIR WRWMLVIFCL AFVLSWLFFG CVFWLIALLH GDLDASKESK 120
ACVSEVNSFT AAFLFSIETQ TTIGYGFRCV TDECPVAVFM VVFQSIVGCI IDAFIIGAVM 180
AKMAKPKKRN ETLVFSHNAV IAMRDGKLCL MWRVGNLRKS HLVEAHVRAQ LLKSRITSEG 240
EYIPLDQIDI NVGFDSGIDR IFLVSPITIV HEIDEDSPLY DLSKQDIDNA DFEIVVILEG 300
MVEATAMTTQ CRSSYLANEI LWGHRYEPVL FEEKQYYKVD YSRFHKTYEV PSTPLCSARD 360
LAEKKYILSN ANSFCYENEV ALTSKEEDDS ENGVPESTST DTPPDIDLHN QASVPLEPRP 420
LRRESEI 427

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologKCNJ2281883O19182Bos taurusPredictionMore>>
1:1 orthologKCNJ2403717Q9MYY9Canis lupus familiarisPredictionMore>>
1:1 orthologKCNJ2102168940A0A452DN29Capra hircusPredictionMore>>
1:1 orthologKCNJ2100052953F7C3Q3Equus caballusPredictionMore>>
1:1 orthologKCNJ23759P63252Homo sapiensPredictionMore>>
1:1 orthologKcnj216518P35561CPOMus musculusPublicationMore>>
1:1 orthologKCNJ2468312H2QDR5Pan troglodytesPredictionMore>>
1:1 orthologKCNJ2397293O18839Sus scrofaPredictionMore>>
1:1 orthologKCNJ2100008987P49656Oryctolagus cuniculusPredictionMore>>
1:1 orthologKcnj229712Q64273Rattus norvegicusPredictionMore>>
1:1 orthologkcnj2a564522E7FGH1Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0008076 voltage-gated potassium channel complex
GO:0042802 identical protein binding
GO:0005242 inward rectifier potassium channel activity
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
GO:0086002 cardiac muscle cell action potential involved in contraction
GO:0015693 magnesium ion transport
GO:1990573 potassium ion import across plasma membrane
GO:0051289 protein homotetramerization
GO:0086091 regulation of heart rate by cardiac conduction
GO:0060306 regulation of membrane repolarization
GO:0014861 regulation of skeletal muscle contraction via regulation of action potential
GO:0055119 relaxation of cardiac muscle
GO:0090076 relaxation of skeletal muscle

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0407 Ion channel
KW-0406 Ion transport
KW-0472 Membrane
KW-0630 Potassium
KW-0633 Potassium transport
KW-1185 Reference proteome
KW-0812 Transmembrane
KW-1133 Transmembrane helix
KW-0813 Transport
KW-0851 Voltage-gated channel

Interpro

InterPro ID InterPro Term
IPR014756 Ig_E-set
IPR041647 IRK_C
IPR016449 K_chnl_inward-rec_Kir
IPR003271 K_chnl_inward-rec_Kir2.1
IPR013518 K_chnl_inward-rec_Kir_cyto
IPR013673 K_chnl_inward-rec_Kir_N
IPR040445 Kir_TM

PROSITE

PROSITE ID PROSITE Term

Pfam

Pfam ID Pfam Term
PF01007 IRK
PF17655 IRK_C
PF08466 IRK_N