| Tag | Content |
|---|---|
| Uniprot ID | H2QDR5; A0A2J8KKW9; |
| Entrez ID | 468312 |
| Genbank protein ID | JAA30266.1 |
| Genbank nucleotide ID | XM_523701.6 |
| Ensembl protein ID | ENSPTRP00000016291 |
| Ensembl nucleotide ID | ENSPTRG00000009590 |
| Gene name | Potassium inwardly-rectifying channel, subfamily J, member 2 |
| Gene symbol | KCNJ2 |
| Organism | Pan troglodytes |
| NCBI taxa ID | 9598 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MGSVRTNRYS IVSSEEDGMK LATMAVANGF GNGKSKVHTR QQCRSRFVKK DGHCNVQFIN 60 VGEKGQRYLA DIFTTCVDIR WRWMLVIFCL AFVLSWLFFG CVFWLIALLH GDLDASKEGK 120 ACVSEVNSFT AAFLFSIETQ TTIGYGFRCV TDECPIAVFM VVFQSIVGCI IDAFIIGAVM 180 AKMAKPKKRN ETLVFSHNAV IAMRDGKLCL MWRVGNLRKS HLVEAHVRAQ LLKSRITSEG 240 EYIPLDQIDI NVGFDSGIDR IFLVSPITIV HEIDEDSPLY DLSKQDIDNA DFEIVVILEG 300 MVEATAMTTQ CRSSYLANEI LWGHRYEPVL FEEKHYYKVD YSRFHKTYEV PNTPLCSARD 360 LAEKKYILSN ANSFCYENEV ALTSKEEDDS ENGVPESTST DTPPDIDLHN QASVPLEPRP 420 LRRESEI 427 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | KCNJ2 | 281883 | O19182 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | KCNJ2 | 403717 | Q9MYY9 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | KCNJ2 | 102168940 | A0A452DN29 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | KCNJ2 | 100052953 | F7C3Q3 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | KCNJ2 | 3759 | P63252 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Kcnj2 | 16518 | P35561 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | KCNJ2 | 468312 | H2QDR5 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | KCNJ2 | 397293 | O18839 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | KCNJ2 | 100008987 | P49656 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Kcnj2 | 29712 | Q64273 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | kcnj2a | 564522 | E7FGH1 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0008076 | voltage-gated potassium channel complex |
| GO:0042802 | identical protein binding |
| GO:0005242 | inward rectifier potassium channel activity |
| GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding |
| GO:0086008 | voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization |
| GO:0086002 | cardiac muscle cell action potential involved in contraction |
| GO:0015693 | magnesium ion transport |
| GO:1990573 | potassium ion import across plasma membrane |
| GO:0051289 | protein homotetramerization |
| GO:0086091 | regulation of heart rate by cardiac conduction |
| GO:0034765 | regulation of ion transmembrane transport |
| GO:0060306 | regulation of membrane repolarization |
| GO:0014861 | regulation of skeletal muscle contraction via regulation of action potential |
| GO:0055119 | relaxation of cardiac muscle |
| GO:0090076 | relaxation of skeletal muscle |