| Tag | Content |
|---|---|
| Uniprot ID | P49656 |
| Entrez ID | 100008987 |
| Genbank protein ID | BAA04636.1; AAB88796.1; |
| Genbank nucleotide ID | XM_017348807.1; XM_017348806.1; NM_001082198.1; |
| Ensembl protein ID | ENSOCUP00000008971 |
| Ensembl nucleotide ID | ENSOCUG00000010416 |
| Gene name | Inward rectifier potassium channel 2 |
| Gene symbol | KCNJ2 |
| Organism | Oryctolagus cuniculus |
| NCBI taxa ID | 9986 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium. |
| Sequence | MGSVRTNRYS IVSSEEDGMK LATMAVANGF GNGKSKVHTR QQCRSRFVKK DGHCNVQFIN 60 VGEKGQRYLA DIFTTCVDIR WRWMLVIFCL AFVLSWLFFG CVFWLIALLH GDLDASRESK 120 ACVSEVNSFT AAFLFSIETQ TTIGYGFRCV TDECPVAVFM VVFQSIVGCI IDAFIIGAVM 180 AKMAKPKKRN ETLVFSHNAV IAMRDGKLCL MWRVGNLRKS HLVEAHVRAQ LLKSRITSEG 240 EYIPLDQIDI NVGFDSGIDR IFLVSPITIV HEIDEDSPLY DLSKQDMDNA DFEIVVILEG 300 MVEATAMTTQ CRSSYLANEI LWGHRYEPVL FEEKHYYKVD YSRFHKTYEV PNTPLCSARD 360 LAEKKYILSN ANSFCYENEV ALTSKEEDDS ENGVPESTST DTPPDIDLHN QASVPLEPRP 420 LRRESEI 427 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | KCNJ2 | 281883 | O19182 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | KCNJ2 | 403717 | Q9MYY9 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | KCNJ2 | 102168940 | A0A452DN29 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | KCNJ2 | 100052953 | F7C3Q3 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | KCNJ2 | 3759 | P63252 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Kcnj2 | 16518 | P35561 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | KCNJ2 | 468312 | H2QDR5 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | KCNJ2 | 397293 | O18839 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | KCNJ2 | 100008987 | P49656 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Kcnj2 | 29712 | Q64273 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | kcnj2a | 564522 | E7FGH1 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0031224 | intrinsic component of membrane |
| GO:0008076 | voltage-gated potassium channel complex |
| GO:0042802 | identical protein binding |
| GO:0005242 | inward rectifier potassium channel activity |
| GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding |
| GO:0086008 | voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization |
| GO:0086002 | cardiac muscle cell action potential involved in contraction |
| GO:0015693 | magnesium ion transport |
| GO:1990573 | potassium ion import across plasma membrane |
| GO:0006813 | potassium ion transport |
| GO:0051289 | protein homotetramerization |
| GO:0086091 | regulation of heart rate by cardiac conduction |
| GO:0060306 | regulation of membrane repolarization |
| GO:0014861 | regulation of skeletal muscle contraction via regulation of action potential |
| GO:0055119 | relaxation of cardiac muscle |
| GO:0090076 | relaxation of skeletal muscle |
| Keyword ID | Keyword Term |
|---|---|
| KW-0407 | Ion channel |
| KW-0406 | Ion transport |
| KW-0449 | Lipoprotein |
| KW-0472 | Membrane |
| KW-0519 | Myristate |
| KW-0630 | Potassium |
| KW-0633 | Potassium transport |
| KW-1185 | Reference proteome |
| KW-0702 | S-nitrosylation |
| KW-0812 | Transmembrane |
| KW-1133 | Transmembrane helix |
| KW-0813 | Transport |
| KW-0851 | Voltage-gated channel |