| Tag | Content |
|---|---|
| Uniprot ID | P35561 |
| Entrez ID | 16518 |
| Genbank protein ID | CAA51526.1; AAB88794.1; |
| Genbank nucleotide ID | NM_008425.4 |
| Ensembl protein ID | ENSMUSP00000037192 |
| Ensembl nucleotide ID | ENSMUSG00000041695 |
| Gene name | Inward rectifier potassium channel 2 |
| Gene symbol | Kcnj2 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 10904001 |
| Functional description | Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium. |
| Sequence | MGSVRTNRYS IVSSEEDGMK LATMAVANGF GNGKSKVHTR QQCRSRFVKK DGHCNVQFIN 60 VGEKGQRYLA DIFTTCVDIR WRWMLVIFCL AFVLSWLFFG CVFWLIALLH GDLDTSKVSK 120 ACVSEVNSFT AAFLFSIETQ TTIGYGFRCV TDECPIAVFM VVFQSIVGCI IDAFIIGAVM 180 AKMAKPKKRN ETLVFSHNAV IAMRDGKLCL MWRVGNLRKS HLVEAHVRAQ LLKSRITSEG 240 EYIPLDQIDI NVGFDSGIDR IFLVSPITIV HEIDEDSPLY DLSKQDIDNA DFEIVVILEG 300 MVEATAMTTQ CRSSYLANEI LWGHRYEPVL FEEKHYYKVD YSRFHKTYEV PNTPLCSARD 360 LAEKKYILSN ANSFCYENEV ALTSKEEEED SENGVPESTS TDSPPGIDLH NQASVPLEPR 420 PLRRESEI 428 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | KCNJ2 | 281883 | O19182 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | KCNJ2 | 403717 | Q9MYY9 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | KCNJ2 | 102168940 | A0A452DN29 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | KCNJ2 | 100052953 | F7C3Q3 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | KCNJ2 | 3759 | P63252 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Kcnj2 | 16518 | P35561 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | KCNJ2 | 468312 | H2QDR5 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | KCNJ2 | 397293 | O18839 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | KCNJ2 | 100008987 | P49656 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Kcnj2 | 29712 | Q64273 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | kcnj2a | 564522 | E7FGH1 | Danio rerio | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005242 | inward rectifier potassium channel activity | ISS |
| GO:0005242 | inward rectifier potassium channel activity | ISO |
| GO:0005242 | inward rectifier potassium channel activity | IBA |
| GO:0005515 | protein binding | IPI |
| GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding | ISO |
| GO:0042802 | identical protein binding | IPI |
| GO:0086008 | voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0006813 | potassium ion transport | ISS |
| GO:0006813 | potassium ion transport | ISO |
| GO:0014861 | regulation of skeletal muscle contraction via regulation of action potential | ISO |
| GO:0015693 | magnesium ion transport | IDA |
| GO:0034765 | regulation of ion transmembrane transport | IBA |
| GO:0051289 | protein homotetramerization | ISS |
| GO:0051289 | protein homotetramerization | ISO |
| GO:0055119 | relaxation of cardiac muscle | ISO |
| GO:0060306 | regulation of membrane repolarization | ISO |
| GO:0071260 | cellular response to mechanical stimulus | IEA |
| GO:0071805 | potassium ion transmembrane transport | ISO |
| GO:0086001 | cardiac muscle cell action potential | IMP |
| GO:0086002 | cardiac muscle cell action potential involved in contraction | ISO |
| GO:0086004 | regulation of cardiac muscle cell contraction | ISO |
| GO:0086011 | membrane repolarization during action potential | ISO |
| GO:0086013 | membrane repolarization during cardiac muscle cell action potential | ISO |
| GO:0086091 | regulation of heart rate by cardiac conduction | ISO |
| GO:0090076 | relaxation of skeletal muscle | ISO |
| GO:1901381 | positive regulation of potassium ion transmembrane transport | ISO |
| GO:1990573 | potassium ion import across plasma membrane | ISO |
| GO:1990573 | potassium ion import across plasma membrane | IBA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005790 | smooth endoplasmic reticulum | ISO |
| GO:0005791 | rough endoplasmic reticulum | ISO |
| GO:0005794 | Golgi apparatus | ISO |
| GO:0005886 | plasma membrane | ISO |
| GO:0008076 | voltage-gated potassium channel complex | ISO |
| GO:0014704 | intercalated disc | ISO |
| GO:0030315 | T-tubule | ISO |
| GO:0030425 | dendrite | ISO |
| GO:0031224 | intrinsic component of membrane | ISS |
| GO:0031224 | intrinsic component of membrane | ISO |
| GO:0043025 | neuronal cell body | ISO |
| GO:0043197 | dendritic spine | ISO |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-112314 | Neurotransmitter receptors and postsynaptic signal transmission | IEA |
| R-MMU-112315 | Transmission across Chemical Synapses | IEA |
| R-MMU-112316 | Neuronal System | IEA |
| R-MMU-1296041 | Activation of G protein gated Potassium channels | IEA |
| R-MMU-1296053 | Classical Kir channels | IEA |
| R-MMU-1296059 | G protein gated Potassium channels | IEA |
| R-MMU-1296065 | Inwardly rectifying K+ channels | IEA |
| R-MMU-1296071 | Potassium Channels | IEA |
| R-MMU-397014 | Muscle contraction | IEA |
| R-MMU-5576886 | Phase 4 - resting membrane potential | IEA |
| R-MMU-5576891 | Cardiac conduction | IEA |
| R-MMU-977443 | GABA receptor activation | IEA |
| R-MMU-977444 | GABA B receptor activation | IEA |
| R-MMU-991365 | Activation of GABAB receptors | IEA |
| R-MMU-997272 | Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits | IEA |
| Keyword ID | Keyword Term |
|---|---|
| KW-0002 | 3D-structure |
| KW-0407 | Ion channel |
| KW-0406 | Ion transport |
| KW-0449 | Lipoprotein |
| KW-0472 | Membrane |
| KW-0519 | Myristate |
| KW-0630 | Potassium |
| KW-0633 | Potassium transport |
| KW-1185 | Reference proteome |
| KW-0702 | S-nitrosylation |
| KW-0812 | Transmembrane |
| KW-1133 | Transmembrane helix |
| KW-0813 | Transport |
| KW-0851 | Voltage-gated channel |