| Tag | Content |
|---|---|
| Uniprot ID | A0A452E0F9 |
| Entrez ID | |
| Genbank protein ID | |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSCHIP00000005497 |
| Ensembl nucleotide ID | ENSCHIG00000009616 |
| Gene name | Fibrillar collagen NC1 domain-containing protein |
| Gene symbol | COL2A1 |
| Organism | Capra hircus |
| NCBI taxa ID | 9925 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MFLVPGFPCF LATQGPGFKA SPISPRQPLP GSAQCSEHLC FGLQGARGFP GTPGLPGVKG 60 HRGYPGLDGA KGEAGAPGVK GESGSPGENG SPGPMGPRGL PGERGRTGPA GAAGARGNDG 120 QPGPAGPPGP VGPAGGPGFP GAPGAKGEAG PTGARGPEGA QGPRGEPGTP GSPGPAGAAG 180 NPGTDGIPGA KGSAGAPGIA GAPGFPGPRG PPGPQGATGP LGPKGQTGEP GIAGFKGEQG 240 PKGEPGPAGP QGAPGPAGEE GKRGARGEPG GAGPAGPPGE RGAPGNRGFP GQDGLAGPKG 300 APGERGPSGL AGPKGANGDP GRPGEPGLPG ARGLTGRPGD AGPQGKVGPS GAPGEDGRPG 360 PPGPQGARGQ PGVMGFPGPK GANGEPGKAG EKGLPGAPGL RGLPGKDGET GAAGPPGPAG 420 PAGERGEQGA PGPSGFQGLP GPPGPPGEGG KPGDQGVPGE AGAPGLVGPR GERGFPGERG 480 SPGSQGLQGA RGLPGTPGTD GPKGAAGPAG PPGAQGPPGL QGMPGERGAA GIAGPKGDRG 540 DVGEKGPEGA PGKDGGRGLT GPIGPPGPAG ANGEKGEVGP PGPAGTAGAR GAPGERGETG 600 PPGPAGFAGP PGADGQPGAK GEQGEAGQKG DAGAPGPQGP SGAPGPQGPT GVTGPKGARG 660 AQGPPGATGF PGAAGRVGPP GSNGNPGPPG PPGPSGKDGP KGARGDSGPP GRAGDPGLQG 720 PAGPPGEKGE PGDDGPSGPD GPPGPQGLAG QRGIVGLPGQ RGERGFPGLP GPSGEPGKQG 780 APGASGDRGP PGPVGPPGLT GPAGEPGREG SPGADGPPGR DGAAGVKGDR GETGAVGAPG 840 APGPPGSPGP AGPVGKQGDR GEAGAQGPMG PAGPAGARGM PGPQGPRGDK GETGEAGERG 900 LKGHRGFTGL QGLPGPPGPS GDQGASGPAG PSGPRGPPGP VGPSGKDGAN GIPGPIGPPG 960 PRGRSGETGP AGPPGNPGPP GPPGPPGPGI DMSAFAGLGQ REKGPDPLQY MRADEAAGNL 1020 RQHDAEVDAT LKSLNNQIES LRSPEGSRKN PARTCRDLKL CHPEWKSGDY WIDPNQGCTL 1080 DAMKVFCNME TGETCVYPNP ASVPKKNWWS SKSKDKKHIW FGETINGGFH FSYGDDNLAP 1140 NTANVQMTFL RLLSTEGSQN ITYHCKNSIA YLDEAAGNLK KALLIQGSND VEIRAEGNSR 1200 FTYTVLKDGC TKHTGKWGET VIEYRSQKTS RLPIIDIAPM DIGGPEQEFG VDIGPVCFL 1259 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | COL2A1 | 407142 | P02459 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | COL2A1 | A0A452E0F9 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | COL2A1 | 791241 | A0A5F5PIB7 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | COL2A1 | 1280 | P02458 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Col2a1 | 12824 | P28481 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | COL2A1 | 451860 | H2Q5S8 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | COL2A1 | 100009005 | G1T5V9 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Col2a1 | F1LRM7 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005604 | basement membrane |
| GO:0005585 | collagen type II trimer |
| GO:0005737 | cytoplasm |
| GO:0005615 | extracellular space |
| GO:0005201 | extracellular matrix structural constituent |
| GO:0042802 | identical protein binding |
| GO:0042289 | MHC class II protein binding |
| GO:0048407 | platelet-derived growth factor binding |
| GO:0043394 | proteoglycan binding |
| GO:0097065 | anterior head development |
| GO:0001502 | cartilage condensation |
| GO:0060351 | cartilage development involved in endochondral bone morphogenesis |
| GO:0071773 | cellular response to BMP stimulus |
| GO:0007417 | central nervous system development |
| GO:0002062 | chondrocyte differentiation |
| GO:0030199 | collagen fibril organization |
| GO:0060272 | embryonic skeletal joint morphogenesis |
| GO:0001958 | endochondral ossification |
| GO:0003007 | heart morphogenesis |
| GO:0042472 | inner ear morphogenesis |
| GO:0060174 | limb bud formation |
| GO:2001240 | negative regulation of extrinsic apoptotic signaling pathway in absence of ligand |
| GO:0030903 | notochord development |
| GO:0071599 | otic vesicle development |
| GO:0006029 | proteoglycan metabolic process |
| GO:0010468 | regulation of gene expression |
| GO:0060021 | roof of mouth development |
| GO:0007605 | sensory perception of sound |
| GO:0001894 | tissue homeostasis |
| GO:0007601 | visual perception |
| Keyword ID | Keyword Term |
|---|---|
| KW-1185 | Reference proteome |
| PROSITE ID | PROSITE Term |
|---|---|
| PS51461 | NC1_FIB |