| Tag | Content |
|---|---|
| Uniprot ID | F1LRM7 |
| Entrez ID | |
| Genbank protein ID | |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSRNOP00000071077 |
| Ensembl nucleotide ID | ENSRNOG00000058560 |
| Gene name | Collagen alpha-1(II) chain |
| Gene symbol | Col2a1 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MIRLGAPQSL VLLTLLIATV LQCQGQDARK LGPKGQKGEP GDIKDIIGPK GPPGPQGPAG 60 EQGPRGDRGD KGERGAPGPR GRDGEPGTPG NPGPPGPPGP PGPPGLGGGN FAAQMAGGFD 120 EKAGGAQMGV MQGPMGPMGP RGPPGPAGAP GPQGFQGNPG EPGEPGVSGP MGPRGPPGPA 180 GKPGDDGEAG KPGKAGERGL PGPQGARGFP GTPGLPGVKG HRGYPGLDGA KGEAGAPGVK 240 GESGSPGENG SPGPMGPRGL PGERGRTGPA GAAGARGNDG QPGPAGPPGP VGPAGGPGFP 300 GAPGAKGEAG PTGARGPEGA QGSRGEPGNP GSPGPAGASG NPGTDGIPGA KGSAGAPGIA 360 GAPGFPGPRG PPGPQGATGP LGPKGQTGEP GIAGFKGEQG PKGETGPAGP QGAPGPAGEE 420 GKRGARGEPG GAGPIGPPGE RGAPGNRGFP GQDGLAGPKG APGERGPSGL AGPKGANGDP 480 GRPGEPGLPG ARGLTGRPGD AGPQGKVGPS GAPGEDGRPG PPGPQGARGQ PGVMGFPGPK 540 GANGEPGKAG EKGLAGAPGL RGLPGKDGET GAAGPPGPSG PAGERGEQGA PGPSGFQGLP 600 GPPGPPGEGG KQGDQGIPGE AGAPGLVGPR GERGFPGERG SPGAQGLQGP RGLPGTPGTD 660 GPKGAAGPDG PPGAQGPPGL QGMPGERGAA GIAGPKGDRG DVGEKGPEGA PGKDGGRGLT 720 GPIGPPGPAG ANGEKGEVGP PGPSGSTGAR GAPGERGETG PPGPAGFAGP PGADGQPGAK 780 GDQGEAGQKG DAGAPGPQGP SGAPGPQGPT GVTGPKGARG AQGPPGATGF PGAAGRVGPP 840 GSNGNPGPAG PPGPAGKDGP KGARGDTGAP GRAGDPGLQG PAGAPGEKGE PGDDGPSGSD 900 GPPGPQGLAG QRGIVGLPGQ RGERGFPGLP GPSGEPGKQG APGASGDRGP PGPVGPPGLT 960 GPAGEPGREG SPGADGPPGR DGAAGVKGDR GETGALGAPG APGPPGSPGP AGPTGKQGDR 1020 GEAGAQGPMG PSGPAGARGI AGPQGPRGDK GEAGEPGERG LKGHRGFTGL QGLPGPPGPS 1080 GDQGTSGPAG PSGPRGPPGP VGPSGKDGSN GIPGPIGPPG PRGRSGETGP AGPPGNPGPP 1140 GPPGPPGPGI DMSAFAGLGQ REKGPDPLQY MRADEADSTL RQHDVEVDAT LKSLNNQIES 1200 IRSPDGSRKN PARTCQDLKL CHPEWKSGDY WIDPNQGCTL DAMKVFCNME TGETCVYPNP 1260 ATVPRKNWWS SKSKEKKHIW FGETMNGGFH FSYGDGNLAP NTANVQMTFL RLLSTEGSQN 1320 ITYHCKNSIA YLDEAAGNLK KALLIQGSND VEMRAEGNSR FTYTALKDGC TKHTGKWGKT 1380 IIEYRSQKTS RLPIVDIAPM DIGGPDQEFG VDIGPVCFL 1419 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | COL2A1 | 407142 | P02459 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | COL2A1 | A0A452E0F9 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | COL2A1 | 791241 | A0A5F5PIB7 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | COL2A1 | 1280 | P02458 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Col2a1 | 12824 | P28481 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | COL2A1 | 451860 | H2Q5S8 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | COL2A1 | 100009005 | G1T5V9 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Col2a1 | F1LRM7 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005604 | basement membrane |
| GO:0005585 | collagen type II trimer |
| GO:0005737 | cytoplasm |
| GO:0005615 | extracellular space |
| GO:0005201 | extracellular matrix structural constituent |
| GO:0042802 | identical protein binding |
| GO:0042289 | MHC class II protein binding |
| GO:0048407 | platelet-derived growth factor binding |
| GO:0043394 | proteoglycan binding |
| GO:0097065 | anterior head development |
| GO:0001502 | cartilage condensation |
| GO:0060351 | cartilage development involved in endochondral bone morphogenesis |
| GO:0071773 | cellular response to BMP stimulus |
| GO:0007417 | central nervous system development |
| GO:0002062 | chondrocyte differentiation |
| GO:0030199 | collagen fibril organization |
| GO:0060272 | embryonic skeletal joint morphogenesis |
| GO:0001958 | endochondral ossification |
| GO:0003007 | heart morphogenesis |
| GO:0042472 | inner ear morphogenesis |
| GO:0060174 | limb bud formation |
| GO:2001240 | negative regulation of extrinsic apoptotic signaling pathway in absence of ligand |
| GO:0030903 | notochord development |
| GO:0071599 | otic vesicle development |
| GO:0006029 | proteoglycan metabolic process |
| GO:0010468 | regulation of gene expression |
| GO:0060021 | roof of mouth development |
| GO:0007605 | sensory perception of sound |
| GO:0001894 | tissue homeostasis |
| GO:0007601 | visual perception |
| PROSITE ID | PROSITE Term |
|---|---|
| PS51461 | NC1_FIB |