| Tag | Content |
|---|---|
| Uniprot ID | A0A452EL03 |
| Entrez ID | |
| Genbank protein ID | |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSCHIP00000012825 |
| Ensembl nucleotide ID | ENSCHIG00000014418 |
| Gene name | TBX domain-containing protein |
| Gene symbol | TBX2 |
| Organism | Capra hircus |
| NCBI taxa ID | 9925 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MREPALAASA MAYHPFHAPR PADFPMSAFL AAAQPSFFPA LALPPGALAK PLPDPGLAGA 60 AAAAAAAAAA AEAGLHVSAL GPHPPAAHLR SLKSLEPEDE VEDDPKVTLE AKELWDQFHK 120 LGTEMVITKS GRRMFPPFKV RVSGLDKKAK YILLMDIVAA DDCRYKFHNS RWMVAGKADP 180 EMPKRMYIHP DSPATGEQWM AKPVAFHKLK LTNNISDKHG FTILNSMHKY QPRFHIVRAN 240 DILKLPYSTF RTYVFPETDF IAVTAYQNDK ITQLKIDNNP FAKGFRDTGN GRREKRKQLT 300 LPSLRLYEEH CKPERDGAES DASSCDPPPA REPPPSPGTA PSPLRLHRTR AEEKSCAVDS 360 DPEPERLGEE RAGPALGRSP ALDSSSPPRL TEPDRARERR SPERGKEPAE SGGDGPFGLR 420 SLEKERAEAR RKDEGRKEAG EGKEPGLAPL VVQTDSASPL GAGHLPGLAF SGHLHGQQFF 480 GPLGAGQPLF LHPGQFAMGP GAFSAMGMGH LLASVAGGGG GGGGGGPGTA TGLDAGGLGP 540 AGSAASTAGP FPFHLSQHML ASQGIPMPTF GGLFPYPYTY MAAAAAAGSL SRSPFLGSAR 600 PRLRFSPYQI PVSIPPSTSL LTTGLAAEGS KAAGGGNSRE PSPLPELALR KVGASARVAL 660 SPGGAAKEAA SELQSIQRLW VQLEIAQGVA LCQSPLGLAP SGPSLPGQLL PQEDGLSTPP 720 HPADRRLQPQ ILAVEGVGER QVIPSDHRGV CPFLSVTPSQ LLPLFEACEC P 771 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | TBX2 | 535982 | E1BLY0 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | TBX2 | J9NV98 | Canis lupus familiaris | Prediction | More>> | |||
| 1:1 ortholog | TBX2 | A0A452EL03 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | TBX2 | 6909 | Q13207 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Tbx2 | 21385 | Q60707 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | TBX2 | 454800 | H2QDL3 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | TBX2 | 100622658 | F8SIP4 | Sus scrofa | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005634 | nucleus |
| GO:0005667 | transcription factor complex |
| GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific |
| GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO:0035909 | aorta morphogenesis |
| GO:0036302 | atrioventricular canal development |
| GO:0048738 | cardiac muscle tissue development |
| GO:0090398 | cellular senescence |
| GO:0060560 | developmental growth involved in morphogenesis |
| GO:0048596 | embryonic camera-type eye morphogenesis |
| GO:0042733 | embryonic digit morphogenesis |
| GO:0003203 | endocardial cushion morphogenesis |
| GO:0060596 | mammary placode formation |
| GO:0007521 | muscle cell fate determination |
| GO:1901211 | negative regulation of cardiac chamber formation |
| GO:1901208 | negative regulation of heart looping |
| GO:0007219 | Notch signaling pathway |
| GO:0003148 | outflow tract septum morphogenesis |
| GO:0060465 | pharynx development |
| GO:0060045 | positive regulation of cardiac muscle cell proliferation |
| GO:0003256 | regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation |
| GO:0060021 | roof of mouth development |