Gene: TBX2

Basic information

Tag Content
Uniprot ID E1BLY0
Entrez ID 535982
Genbank protein ID
Genbank nucleotide ID NM_001191443.1
Ensembl protein ID ENSBTAP00000018970
Ensembl nucleotide ID ENSBTAG00000014278
Gene name T-box transcription factor 2
Gene symbol TBX2
Organism Bos taurus
NCBI taxa ID 9913
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MREPALAASA MAYHPFHAPR PADFPMSAFL AAAQPSFFPA LALPPGALAK PLPDPGLAGA 60
AAAAAAAAAA AEAGLHVSAL GPHPPAAHLR SLKSLEPEDE VEDDPKVTLE AKELWDQFHK 120
LGTEMVITKS GRRMFPPFKV RVSGLDKKAK YILLMDIVAA DDCRYKFHNS RWMVAGKADP 180
EMPKRMYIHP DSPATGEQWM AKPVAFHKLK LTNNISDKHG FTILNSMHKY QPRFHIVRAN 240
DILKLPYSTF RTYVFPETDF IAVTAYQNDK ITQLKIDNNP FAKGFRDTGN GRREKRKQLT 300
LPSLRLYEEH CKPERDGAES DASSCDPPPA REPPPSPGTA PSPLRLHRTR AEEKSCAADS 360
DPEPERLGEE RAGPALGRSP ALDSSSPPRL TEPDRARERR SPERGKEPAE SGGDGPFGLR 420
SLEKERAEAR RKDEGRKEAS EGKEPGLAPL VVQTDSASPL GAGHLPGLAF SGHLHGQQFF 480
GPLGAGQPLF LHPGQFAMGP GAFSAMGMGH LLASVAGGGG GGGGGGPGTA TGLDAGGLGP 540
AGSAASTAGP FPFHLSQHML ASQGIPMPTF GGLFPYPYTY MAAAAAAASA LPATSAAAAA 600
AAAAGSLSRS PFLGSARPRL RFSPYQIPVS IPPSTSLLTT GLAAEGSKAA GGGNSREPSP 660
LPELALRKVG APARVALSPG GAAKEAASEL QSIQRLVSGL ESQRALSPGR ESPK 714

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologTBX2535982E1BLY0Bos taurusPredictionMore>>
1:1 orthologTBX2J9NV98Canis lupus familiarisPredictionMore>>
1:1 orthologTBX2A0A452EL03Capra hircusPredictionMore>>
1:1 orthologTBX26909Q13207Homo sapiensPredictionMore>>
1:1 orthologTbx221385Q60707CPOMus musculusPublicationMore>>
1:1 orthologTBX2454800H2QDL3Pan troglodytesPredictionMore>>
1:1 orthologTBX2100622658F8SIP4Sus scrofaPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001102 RNA polymerase II activating transcription factor binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0035909 aorta morphogenesis
GO:0036302 atrioventricular canal development
GO:0003205 cardiac chamber development
GO:0048738 cardiac muscle tissue development
GO:0001708 cell fate specification
GO:0090398 cellular senescence
GO:0007417 central nervous system development
GO:0060560 developmental growth involved in morphogenesis
GO:0048596 embryonic camera-type eye morphogenesis
GO:0042733 embryonic digit morphogenesis
GO:0003203 endocardial cushion morphogenesis
GO:0001947 heart looping
GO:0060596 mammary placode formation
GO:0007521 muscle cell fate determination
GO:1901211 negative regulation of cardiac chamber formation
GO:1901208 negative regulation of heart looping
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0007219 Notch signaling pathway
GO:0003148 outflow tract septum morphogenesis
GO:0060465 pharynx development
GO:0060045 positive regulation of cardiac muscle cell proliferation
GO:0008284 positive regulation of cell population proliferation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0003256 regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation
GO:0060021 roof of mouth development

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0175 Coiled coil
KW-0238 DNA-binding
KW-0539 Nucleus
KW-1185 Reference proteome
KW-0804 Transcription
KW-0805 Transcription regulation

Interpro

InterPro ID InterPro Term
IPR008967 p53-like_TF_DNA-bd
IPR036960 T-box_sf
IPR022582 TBX
IPR002070 TF_Brachyury
IPR001699 TF_T-box
IPR018186 TF_T-box_CS

PROSITE

PROSITE ID PROSITE Term
PS01283 TBOX_1
PS01264 TBOX_2
PS50252 TBOX_3

Pfam

Pfam ID Pfam Term
PF00907 T-box
PF12598 TBX