| Tag | Content |
|---|---|
| Uniprot ID | E1BLY0 |
| Entrez ID | 535982 |
| Genbank protein ID | |
| Genbank nucleotide ID | NM_001191443.1 |
| Ensembl protein ID | ENSBTAP00000018970 |
| Ensembl nucleotide ID | ENSBTAG00000014278 |
| Gene name | T-box transcription factor 2 |
| Gene symbol | TBX2 |
| Organism | Bos taurus |
| NCBI taxa ID | 9913 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MREPALAASA MAYHPFHAPR PADFPMSAFL AAAQPSFFPA LALPPGALAK PLPDPGLAGA 60 AAAAAAAAAA AEAGLHVSAL GPHPPAAHLR SLKSLEPEDE VEDDPKVTLE AKELWDQFHK 120 LGTEMVITKS GRRMFPPFKV RVSGLDKKAK YILLMDIVAA DDCRYKFHNS RWMVAGKADP 180 EMPKRMYIHP DSPATGEQWM AKPVAFHKLK LTNNISDKHG FTILNSMHKY QPRFHIVRAN 240 DILKLPYSTF RTYVFPETDF IAVTAYQNDK ITQLKIDNNP FAKGFRDTGN GRREKRKQLT 300 LPSLRLYEEH CKPERDGAES DASSCDPPPA REPPPSPGTA PSPLRLHRTR AEEKSCAADS 360 DPEPERLGEE RAGPALGRSP ALDSSSPPRL TEPDRARERR SPERGKEPAE SGGDGPFGLR 420 SLEKERAEAR RKDEGRKEAS EGKEPGLAPL VVQTDSASPL GAGHLPGLAF SGHLHGQQFF 480 GPLGAGQPLF LHPGQFAMGP GAFSAMGMGH LLASVAGGGG GGGGGGPGTA TGLDAGGLGP 540 AGSAASTAGP FPFHLSQHML ASQGIPMPTF GGLFPYPYTY MAAAAAAASA LPATSAAAAA 600 AAAAGSLSRS PFLGSARPRL RFSPYQIPVS IPPSTSLLTT GLAAEGSKAA GGGNSREPSP 660 LPELALRKVG APARVALSPG GAAKEAASEL QSIQRLVSGL ESQRALSPGR ESPK 714 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | TBX2 | 535982 | E1BLY0 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | TBX2 | J9NV98 | Canis lupus familiaris | Prediction | More>> | |||
| 1:1 ortholog | TBX2 | A0A452EL03 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | TBX2 | 6909 | Q13207 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Tbx2 | 21385 | Q60707 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | TBX2 | 454800 | H2QDL3 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | TBX2 | 100622658 | F8SIP4 | Sus scrofa | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005634 | nucleus |
| GO:0005667 | transcription factor complex |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific |
| GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific |
| GO:0001102 | RNA polymerase II activating transcription factor binding |
| GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding |
| GO:0035909 | aorta morphogenesis |
| GO:0036302 | atrioventricular canal development |
| GO:0003205 | cardiac chamber development |
| GO:0048738 | cardiac muscle tissue development |
| GO:0001708 | cell fate specification |
| GO:0090398 | cellular senescence |
| GO:0007417 | central nervous system development |
| GO:0060560 | developmental growth involved in morphogenesis |
| GO:0048596 | embryonic camera-type eye morphogenesis |
| GO:0042733 | embryonic digit morphogenesis |
| GO:0003203 | endocardial cushion morphogenesis |
| GO:0001947 | heart looping |
| GO:0060596 | mammary placode formation |
| GO:0007521 | muscle cell fate determination |
| GO:1901211 | negative regulation of cardiac chamber formation |
| GO:1901208 | negative regulation of heart looping |
| GO:0000122 | negative regulation of transcription by RNA polymerase II |
| GO:0007219 | Notch signaling pathway |
| GO:0003148 | outflow tract septum morphogenesis |
| GO:0060465 | pharynx development |
| GO:0060045 | positive regulation of cardiac muscle cell proliferation |
| GO:0008284 | positive regulation of cell population proliferation |
| GO:0045944 | positive regulation of transcription by RNA polymerase II |
| GO:0003256 | regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation |
| GO:0060021 | roof of mouth development |