| Tag | Content |
|---|---|
| Uniprot ID | J9NV98 |
| Entrez ID | |
| Genbank protein ID | |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSCAFP00000037090 |
| Ensembl nucleotide ID | ENSCAFG00000017745 |
| Gene name | T-box transcription factor 2 |
| Gene symbol | TBX2 |
| Organism | Canis lupus familiaris |
| NCBI taxa ID | 9615 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MGNHIIREGL TRGNGISQEK QPQVGVSQAV IWRQSSDNRD TQMGKLMAAV CACALGPSDI 60 KLVPWSLLRS LSRRRMFPPF KVRVSGLDKK AKYILLMDIV AADDCRYKFH NSRWMVAGKA 120 DPEMPKRMYI HPDSPATGEQ WMGKPVAFHK LKLTNNISDK HGFTILNSMH KYQPRFHIVR 180 ANDILKLPYS TFRTYVFPET DFIAVTAYQN DKITQLKIDN NPFAKGFRDT GNGRREKRKQ 240 LTLPSLRLYE EHCKPERDGA ESDASSCDPA PAREPPASPG SAPSPLRLHR TRADEKCAAD 300 SDPEPERLSE ERAGPALGRS PGLDGGSPPR LTEPERARER RSPERGKEPA ESGGDGPFGL 360 RSLEKERAEA RRKDDGRKEA GEGKEPGLAP LVVQTDSASP LGAGHLPGLA FSGHLHGQQF 420 FGPLGAGQPL FLHPGQFAMG PGAFSAMGMG HLLASVAGGG GGGGGGGPGT ATGLDAGGLG 480 PAASAASTPA PFPFHLSQHM LASQGIPMPT FGGLFPYPYT YMAAAAAAAS ALPATSAAAA 540 AAAAAGSLSR SHFLGSARPR LRFSPYQIPV TIPPSTSLLT TGLAAEGSKA AGSNSREPSP 600 LPELALRKVG APSRGALSPS GSAKEAASEL QSIQRLGRGL GWEDGSPTHQ EHQER 655 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | TBX2 | 535982 | E1BLY0 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | TBX2 | J9NV98 | Canis lupus familiaris | Prediction | More>> | |||
| 1:1 ortholog | TBX2 | A0A452EL03 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | TBX2 | 6909 | Q13207 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Tbx2 | 21385 | Q60707 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | TBX2 | 454800 | H2QDL3 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | TBX2 | 100622658 | F8SIP4 | Sus scrofa | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005634 | nucleus |
| GO:0005667 | transcription factor complex |
| GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific |
| GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO:0035909 | aorta morphogenesis |
| GO:0036302 | atrioventricular canal development |
| GO:0048738 | cardiac muscle tissue development |
| GO:0090398 | cellular senescence |
| GO:0060560 | developmental growth involved in morphogenesis |
| GO:0048596 | embryonic camera-type eye morphogenesis |
| GO:0042733 | embryonic digit morphogenesis |
| GO:0003203 | endocardial cushion morphogenesis |
| GO:0060596 | mammary placode formation |
| GO:0007521 | muscle cell fate determination |
| GO:1901211 | negative regulation of cardiac chamber formation |
| GO:1901208 | negative regulation of heart looping |
| GO:0007219 | Notch signaling pathway |
| GO:0003148 | outflow tract septum morphogenesis |
| GO:0060465 | pharynx development |
| GO:0060045 | positive regulation of cardiac muscle cell proliferation |
| GO:0003256 | regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation |
| GO:0060021 | roof of mouth development |