Gene: GRB2

Basic information

Tag Content
Uniprot ID A0A452ET74
Entrez ID 102170356
Genbank protein ID
Genbank nucleotide ID XM_018063823.1
Ensembl protein ID ENSCHIP00000015407
Ensembl nucleotide ID ENSCHIG00000016061
Gene name Uncharacterized protein
Gene symbol GRB2
Organism Capra hircus
NCBI taxa ID 9925
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MEAIAKYDFK ATADDELSFK RGDILKVLNE ECDQNWYKAE LNGKDGFIPK NYIEMKPHPW 60
FFGKIPRAKA EEMLSKQRHD GAFLIRESES APGDFSLSVK FGNDVQHFKV LRDGAGKYFL 120
WVVKFNSLNE LVDYHRSTSV SRNQQIFLRD IEQVPQQPTY VQALFDFDPQ EDGELGFRRG 180
DFIHVMDNSD PNWWKGACHG QTGMFPRNYV TPVNRNV 217

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologGRB2535298Q3T0F9Bos taurusPredictionMore>>
1:1 orthologGRB2102170356A0A452ET74Capra hircusPredictionMore>>
1:1 orthologGRB2100051866F7BQS3Equus caballusPredictionMore>>
1:1 orthologGRB22885P62993Homo sapiensPredictionMore>>
1:1 orthologGrb214784Q60631CPOMus musculusPublicationMore>>
1:1 orthologGRB2737245G2HGD2Pan troglodytesPredictionMore>>
1:1 orthologGRB2100192436B6E241Sus scrofaPredictionMore>>
1:1 orthologGRB2100342500G1SR27Oryctolagus cuniculusPredictionMore>>
1:1 orthologGrb281504P62994Rattus norvegicusPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005911 cell-cell junction
GO:0008180 COP9 signalosome
GO:0005768 endosome
GO:0070436 Grb2-EGFR complex
GO:0005730 nucleolus
GO:0005654 nucleoplasm
GO:0012506 vesicle membrane
GO:0046875 ephrin receptor binding
GO:0005154 epidermal growth factor receptor binding
GO:0042802 identical protein binding
GO:0043560 insulin receptor substrate binding
GO:0005168 neurotrophin TRKA receptor binding
GO:0001784 phosphotyrosine residue binding
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0017124 SH3 domain binding
GO:0005070 SH3/SH2 adaptor activity
GO:0048646 anatomical structure formation involved in morphogenesis
GO:0060670 branching involved in labyrinthine layer morphogenesis
GO:0030154 cell differentiation
GO:0071479 cellular response to ionizing radiation
GO:0008286 insulin receptor signaling pathway
GO:0030838 positive regulation of actin filament polymerization
GO:2000379 positive regulation of reactive oxygen species metabolic process
GO:0031623 receptor internalization
GO:0043408 regulation of MAPK cascade
GO:0042770 signal transduction in response to DNA damage

Functional annotations

Keywords

Keyword ID Keyword Term
KW-1185 Reference proteome
KW-0727 SH2 domain
KW-0728 SH3 domain

Interpro

InterPro ID InterPro Term
IPR030219 Grb2
IPR035643 GRB2_C_SH3
IPR035641 GRB2_N_SH3
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain

PROSITE

PROSITE ID PROSITE Term
PS50001 SH2
PS50002 SH3

Pfam

Pfam ID Pfam Term
PF00017 SH2
PF00018 SH3_1