CleftGeneDB-Search

Tag	Content
Uniprot ID	Q60631; Q61240;
Entrez ID	14784
Genbank protein ID	BAA12862.1; AAH85254.1; AAB40022.1; AAH52377.1;
Genbank nucleotide ID	NM_001313937.1; NM_008163.4; NM_001313936.1;
Ensembl protein ID	ENSMUSP00000021090; ENSMUSP00000102106; ENSMUSP00000102108;
Ensembl nucleotide ID	ENSMUSG00000059923
Gene name	Growth factor receptor-bound protein 2
Gene symbol	Grb2
Organism	Mus musculus
NCBI taxa ID	10090
Cleft type	CPO
Developmental stage
Data sources	Manually collected
Reference	11369229
Functional description	Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.
Sequence	MEAIAKYDFK ATADDELSFK RGDILKVLNE ECDQNWYKAE LNGKDGFIPK NYIEMKPHPW 60 FFGKIPRAKA EEMLSKQRHD GAFLIRESES APGDFSLSVK FGNDVQHFKV LRDGAGKYFL 120 WVVKFNSLNE LVDYHRSTSV SRNQQIFLRD IEQMPQQPTY VQALFDFDPQ EDGELGFRRG 180 DFIHVMDNSD PNWWKGACHG QTGMFPRNYV TPVNRNV 217

PDB ID
1GBQ
1GBR
2GBQ
3GBQ
4GBQ
1GBQ

Relation	Gene symbol	Entrez ID	UniProt ID	Cleft type	Species	Evidence	Details
1:1 ortholog	GRB2	535298	Q3T0F9		Bos taurus	Prediction	More>>
1:1 ortholog	GRB2	102170356	A0A452ET74		Capra hircus	Prediction	More>>
1:1 ortholog	GRB2	100051866	F7BQS3		Equus caballus	Prediction	More>>
1:1 ortholog	GRB2	2885	P62993		Homo sapiens	Prediction	More>>
1:1 ortholog	Grb2	14784	Q60631	CPO	Mus musculus	Publication	More>>
1:1 ortholog	GRB2	737245	G2HGD2		Pan troglodytes	Prediction	More>>
1:1 ortholog	GRB2	100192436	B6E241		Sus scrofa	Prediction	More>>
1:1 ortholog	GRB2	100342500	G1SR27		Oryctolagus cuniculus	Prediction	More>>
1:1 ortholog	Grb2	81504	P62994		Rattus norvegicus	Prediction	More>>

GO ID	GO Term	Evidence
GO:0001784	phosphotyrosine residue binding	ISO
GO:0005070	SH3/SH2 adaptor activity	IDA
GO:0005154	epidermal growth factor receptor binding	ISO
GO:0005168	neurotrophin TRKA receptor binding	ISO
GO:0005515	protein binding	IPI
GO:0017124	SH3 domain binding	ISS
GO:0017124	SH3 domain binding	ISO
GO:0019899	enzyme binding	ISO
GO:0019901	protein kinase binding	ISO
GO:0019903	protein phosphatase binding	IPI
GO:0019904	protein domain specific binding	ISO
GO:0019904	protein domain specific binding	IPI
GO:0042802	identical protein binding	ISO
GO:0043560	insulin receptor substrate binding	ISO
GO:0044877	protein-containing complex binding	ISO
GO:0046875	ephrin receptor binding	ISO
GO:0046875	ephrin receptor binding	IPI
GO:0051219	phosphoprotein binding	ISO

GO ID	GO Term	Evidence
GO:0007265	Ras protein signal transduction	TAS
GO:0007568	aging	ISO
GO:0008286	insulin receptor signaling pathway	ISO
GO:0009967	positive regulation of signal transduction	IEA
GO:0030154	cell differentiation	IMP
GO:0030838	positive regulation of actin filament polymerization	IGI
GO:0031623	receptor internalization	ISO
GO:0042770	signal transduction in response to DNA damage	ISO
GO:0043408	regulation of MAPK cascade	IGI
GO:0048646	anatomical structure formation involved in morphogenesis	IMP
GO:0060670	branching involved in labyrinthine layer morphogenesis	IMP
GO:0071479	cellular response to ionizing radiation	ISO
GO:2000379	positive regulation of reactive oxygen species metabolic process	ISO

GO ID	GO Term	Evidence
GO:0005634	nucleus	ISS
GO:0005634	nucleus	ISO
GO:0005654	nucleoplasm	ISO
GO:0005730	nucleolus	ISO
GO:0005737	cytoplasm	ISO
GO:0005737	cytoplasm	IDA
GO:0005768	endosome	ISS
GO:0005768	endosome	ISO
GO:0005794	Golgi apparatus	IEA
GO:0005829	cytosol	TAS
GO:0005886	plasma membrane	IDA
GO:0005911	cell-cell junction	IDA
GO:0008180	COP9 signalosome	ISO
GO:0008180	COP9 signalosome	IDA
GO:0012506	vesicle membrane	IDA
GO:0016020	membrane	IDA
GO:0032991	protein-containing complex	ISO
GO:0070436	Grb2-EGFR complex	ISO

Reactome ID	Reactome Term	Evidence
R-MMU-109582	Hemostasis	IEA
R-MMU-109704	PI3K Cascade	IEA
R-MMU-112399	IRS-mediated signalling	IEA
R-MMU-112412	SOS-mediated signalling	IEA
R-MMU-1227986	Signaling by ERBB2	IEA
R-MMU-1236394	Signaling by ERBB4	IEA
R-MMU-1250347	SHC1 events in ERBB4 signaling	IEA
R-MMU-1257604	PIP3 activates AKT signaling	IEA
R-MMU-1266738	Developmental Biology	IEA
R-MMU-1280215	Cytokine Signaling in Immune system	IEA
R-MMU-1280218	Adaptive Immune System	IEA
R-MMU-1295596	Spry regulation of FGF signaling	IEA
R-MMU-1433557	Signaling by SCF-KIT	IEA
R-MMU-1433559	Regulation of KIT signaling	IEA
R-MMU-1500931	Cell-Cell communication	IEA
R-MMU-162582	Signal Transduction	IEA
R-MMU-166520	Signaling by NTRKs	IEA
R-MMU-167044	Signalling to RAS	IEA
R-MMU-168249	Innate Immune System	IEA
R-MMU-168256	Immune System	IEA
R-MMU-177929	Signaling by EGFR	IEA
R-MMU-179812	GRB2 events in EGFR signaling	IEA
R-MMU-180292	GAB1 signalosome	IEA
R-MMU-180336	SHC1 events in EGFR signaling	IEA
R-MMU-182971	EGFR downregulation	IEA
R-MMU-186763	Downstream signal transduction	IEA
R-MMU-186797	Signaling by PDGF	IEA
R-MMU-187037	Signaling by NTRK1 (TRKA)	IEA
R-MMU-187687	Signalling to ERKs	IEA
R-MMU-190236	Signaling by FGFR	IEA
R-MMU-194315	Signaling by Rho GTPases	IEA
R-MMU-195258	RHO GTPase Effectors	IEA
R-MMU-1963640	GRB2 events in ERBB2 signaling	IEA
R-MMU-1963642	PI3K events in ERBB2 signaling	IEA
R-MMU-199418	Negative regulation of the PI3K/AKT network	IEA
R-MMU-199991	Membrane Trafficking	IEA
R-MMU-202733	Cell surface interactions at the vascular wall	IEA
R-MMU-2029480	Fcgamma receptor (FCGR) dependent phagocytosis	IEA
R-MMU-2029482	Regulation of actin dynamics for phagocytic cup formation	IEA
R-MMU-210993	Tie2 Signaling	IEA
R-MMU-2172127	DAP12 interactions	IEA
R-MMU-2179392	EGFR Transactivation by Gastrin	IEA
R-MMU-2404192	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	IEA
R-MMU-2424491	DAP12 signaling	IEA
R-MMU-2428924	IGF1R signaling cascade	IEA
R-MMU-2428928	IRS-related events triggered by IGF1R	IEA
R-MMU-2428933	SHC-related events triggered by IGF1R	IEA
R-MMU-2454202	Fc epsilon receptor (FCERI) signaling	IEA
R-MMU-2730905	Role of LAT2/NTAL/LAB on calcium mobilization	IEA
R-MMU-2871796	FCERI mediated MAPK activation	IEA
R-MMU-2871809	FCERI mediated Ca+2 mobilization	IEA
R-MMU-354192	Integrin signaling	IEA
R-MMU-354194	GRB2:SOS provides linkage to MAPK signaling for Integrins	IEA
R-MMU-372790	Signaling by GPCR	IEA
R-MMU-375165	NCAM signaling for neurite out-growth	IEA
R-MMU-388396	GPCR downstream signalling	IEA
R-MMU-388841	Costimulation by the CD28 family	IEA
R-MMU-389356	CD28 co-stimulation	IEA
R-MMU-389359	CD28 dependent Vav1 pathway	IEA
R-MMU-391160	Signal regulatory protein family interactions	IEA
R-MMU-416476	G alpha (q) signalling events	IEA
R-MMU-422475	Axon guidance	IEA
R-MMU-449147	Signaling by Interleukins	IEA
R-MMU-451927	Interleukin-2 family signaling	IEA
R-MMU-512988	Interleukin-3, Interleukin-5 and GM-CSF signaling	IEA
R-MMU-5653656	Vesicle-mediated transport	IEA
R-MMU-5654687	Downstream signaling of activated FGFR1	IEA
R-MMU-5654688	SHC-mediated cascade:FGFR1	IEA
R-MMU-5654689	PI-3K cascade:FGFR1	IEA
R-MMU-5654693	FRS-mediated FGFR1 signaling	IEA
R-MMU-5654695	PI-3K cascade:FGFR2	IEA
R-MMU-5654696	Downstream signaling of activated FGFR2	IEA
R-MMU-5654699	SHC-mediated cascade:FGFR2	IEA
R-MMU-5654700	FRS-mediated FGFR2 signaling	IEA
R-MMU-5654704	SHC-mediated cascade:FGFR3	IEA
R-MMU-5654706	FRS-mediated FGFR3 signaling	IEA
R-MMU-5654708	Downstream signaling of activated FGFR3	IEA
R-MMU-5654710	PI-3K cascade:FGFR3	IEA
R-MMU-5654712	FRS-mediated FGFR4 signaling	IEA
R-MMU-5654716	Downstream signaling of activated FGFR4	IEA
R-MMU-5654719	SHC-mediated cascade:FGFR4	IEA
R-MMU-5654720	PI-3K cascade:FGFR4	IEA
R-MMU-5654726	Negative regulation of FGFR1 signaling	IEA
R-MMU-5654727	Negative regulation of FGFR2 signaling	IEA
R-MMU-5654732	Negative regulation of FGFR3 signaling	IEA
R-MMU-5654733	Negative regulation of FGFR4 signaling	IEA
R-MMU-5654736	Signaling by FGFR1	IEA
R-MMU-5654738	Signaling by FGFR2	IEA
R-MMU-5654741	Signaling by FGFR3	IEA
R-MMU-5654743	Signaling by FGFR4	IEA
R-MMU-5663213	RHO GTPases Activate WASPs and WAVEs	IEA
R-MMU-5673001	RAF/MAP kinase cascade	IEA
R-MMU-5683057	MAPK family signaling cascades	IEA
R-MMU-5684996	MAPK1/MAPK3 signaling	IEA
R-MMU-6806834	Signaling by MET	IEA
R-MMU-6807004	Negative regulation of MET activity	IEA
R-MMU-6811558	PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	IEA
R-MMU-74749	Signal attenuation	IEA
R-MMU-74751	Insulin receptor signalling cascade	IEA
R-MMU-74752	Signaling by Insulin receptor	IEA
R-MMU-76002	Platelet activation, signaling and aggregation	IEA
R-MMU-76009	Platelet Aggregation (Plug Formation)	IEA
R-MMU-881907	Gastrin-CREB signalling pathway via PKC and MAPK	IEA
R-MMU-8851805	MET activates RAS signaling	IEA
R-MMU-8851907	MET activates PI3K/AKT signaling	IEA
R-MMU-8853659	RET signaling	IEA
R-MMU-8856825	Cargo recognition for clathrin-mediated endocytosis	IEA
R-MMU-8856828	Clathrin-mediated endocytosis	IEA
R-MMU-8865999	MET activates PTPN11	IEA
R-MMU-8875555	MET activates RAP1 and RAC1	IEA
R-MMU-8875656	MET receptor recycling	IEA
R-MMU-8875878	MET promotes cell motility	IEA
R-MMU-8983432	Interleukin-15 signaling	IEA
R-MMU-9006115	Signaling by NTRK2 (TRKB)	IEA
R-MMU-9006335	Signaling by Erythropoietin	IEA
R-MMU-9006925	Intracellular signaling by second messengers	IEA
R-MMU-9006934	Signaling by Receptor Tyrosine Kinases	IEA
R-MMU-9027284	Erythropoietin activates RAS	IEA
R-MMU-9028731	Activated NTRK2 signals through FRS2 and FRS3	IEA
R-MMU-912526	Interleukin receptor SHC signaling	IEA
R-MMU-912631	Regulation of signaling by CBL	IEA
R-MMU-9607240	FLT3 Signaling	IEA
R-MMU-9645139	Stat5 Activation	TAS
R-MMU-983695	Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	IEA
R-MMU-983705	Signaling by the B Cell Receptor (BCR)	IEA

Keyword ID	Keyword Term
KW-0002	3D-structure
KW-0007	Acetylation
KW-0025	Alternative splicing
KW-0963	Cytoplasm
KW-0903	Direct protein sequencing
KW-0967	Endosome
KW-0333	Golgi apparatus
KW-0539	Nucleus
KW-0597	Phosphoprotein
KW-1185	Reference proteome
KW-0677	Repeat
KW-0727	SH2 domain
KW-0728	SH3 domain

InterPro ID	InterPro Term
IPR030219	Grb2
IPR035643	GRB2_C_SH3
IPR035641	GRB2_N_SH3
IPR000980	SH2
IPR036860	SH2_dom_sf
IPR036028	SH3-like_dom_sf
IPR001452	SH3_domain

PROSITE ID	PROSITE Term
PS50001	SH2
PS50002	SH3

Pfam ID	Pfam Term
PF00017	SH2
PF00018	SH3_1

Gene: Grb2

Basic information

Protein structural annotations

3D structure in PDB database

Protein disorder information

Orthologous information

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO:Biological Process

GO:Cellular Component

Reactome Pathway

Functional annotations

Keywords

Interpro

PROSITE

Pfam

Protein-protein interaction

Protein-miRNA interaction