| Tag | Content |
|---|---|
| Uniprot ID | Q3T0F9 |
| Entrez ID | 535298 |
| Genbank protein ID | AAI02412.1 |
| Genbank nucleotide ID | NM_001034630.1; XM_010816566.1; |
| Ensembl protein ID | ENSBTAP00000006216 |
| Ensembl nucleotide ID | ENSBTAG00000004736 |
| Gene name | Growth factor receptor-bound protein 2 |
| Gene symbol | GRB2 |
| Organism | Bos taurus |
| NCBI taxa ID | 9913 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MEAIAKYDFK ATADDELSFK RGDILKVLNE ECDQNWYKAE LNGKDGFIPK NYIEMKPHPW 60 FFGKIPRAKA EEMLSKQRHD GAFLIRESES APGDFSLSVK FGNDVQHFKV LRDGAGKYFL 120 WVVKFNSLNE LVDYHRSTSV SRNQQIFLRD IEQVPQQPTY VQALFDFDPQ EDGELGFRRG 180 DFIHVMDNSD PNWWKGACHG QTGMFPRNYV TPVNRNV 217 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | GRB2 | 535298 | Q3T0F9 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | GRB2 | 102170356 | A0A452ET74 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | GRB2 | 100051866 | F7BQS3 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | GRB2 | 2885 | P62993 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Grb2 | 14784 | Q60631 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | GRB2 | 737245 | G2HGD2 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | GRB2 | 100192436 | B6E241 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | GRB2 | 100342500 | G1SR27 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Grb2 | 81504 | P62994 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005911 | cell-cell junction |
| GO:0008180 | COP9 signalosome |
| GO:0005768 | endosome |
| GO:0070436 | Grb2-EGFR complex |
| GO:0005730 | nucleolus |
| GO:0005654 | nucleoplasm |
| GO:0012506 | vesicle membrane |
| GO:0046875 | ephrin receptor binding |
| GO:0005154 | epidermal growth factor receptor binding |
| GO:0042802 | identical protein binding |
| GO:0043560 | insulin receptor substrate binding |
| GO:0005168 | neurotrophin TRKA receptor binding |
| GO:0001784 | phosphotyrosine residue binding |
| GO:0019901 | protein kinase binding |
| GO:0019903 | protein phosphatase binding |
| GO:0017124 | SH3 domain binding |
| GO:0005070 | SH3/SH2 adaptor activity |
| GO:0048646 | anatomical structure formation involved in morphogenesis |
| GO:0060670 | branching involved in labyrinthine layer morphogenesis |
| GO:0030154 | cell differentiation |
| GO:0071479 | cellular response to ionizing radiation |
| GO:0008286 | insulin receptor signaling pathway |
| GO:0030838 | positive regulation of actin filament polymerization |
| GO:2000379 | positive regulation of reactive oxygen species metabolic process |
| GO:0031623 | receptor internalization |
| GO:0043408 | regulation of MAPK cascade |
| GO:0042770 | signal transduction in response to DNA damage |