| Tag | Content |
|---|---|
| Uniprot ID | A0A452FMK4 |
| Entrez ID | 102185957 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_018065909.1 |
| Ensembl protein ID | ENSCHIP00000025559 |
| Ensembl nucleotide ID | ENSCHIG00000022285 |
| Gene name | Homeobox domain-containing protein |
| Gene symbol | GSC |
| Organism | Capra hircus |
| NCBI taxa ID | 9925 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MPASMFSIDN ILAARPRCKD SVLPVAPSAA APVVFPALHG DSLYGGAGGG ASSDYGAFYP 60 RPVAPGGAGL PAAVGGSRLG YSNYFYGQLH VQAAPVGPAC CGAVPPLGAQ QCSCVPTPPG 120 YEGPGSVLVS PVPHQMMPYM NVGTLSRTEL QLLNQLHCRR KRRHRTIFTD EQLEALENLF 180 QETKYPDVGT REQLARKVHL REEKVEVWFK NRRAKWRRQK RSSSEESENA EKWNKTSSKA 240 SPEKREEEGK SDLDSDS 257 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | GSC | 514862 | E1BB15 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | GSC | 102185957 | A0A452FMK4 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | GSC | 145258 | P56915 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Gsc | 14836 | Q02591 | CPO | E12.5, E13.75, E13.5, E14.5, E15.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | GSC | 467546 | A2T733 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | GSC | 397342 | F1SCC4 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | Gsc | 317715 | G3V7E7 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | gsc | Q7ZZR4 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005634 | nucleus |
| GO:0005667 | transcription factor complex |
| GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific |
| GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO:0001103 | RNA polymerase II repressing transcription factor binding |
| GO:0001085 | RNA polymerase II transcription factor binding |
| GO:0021904 | dorsal/ventral neural tube patterning |
| GO:0048704 | embryonic skeletal system morphogenesis |
| GO:0030900 | forebrain development |
| GO:0042474 | middle ear morphogenesis |
| GO:0048644 | muscle organ morphogenesis |
| GO:0030178 | negative regulation of Wnt signaling pathway |
| GO:0014036 | neural crest cell fate specification |
| GO:0023019 | signal transduction involved in regulation of gene expression |
| Pfam ID | Pfam Term |
|---|---|
| PF00046 | Homeodomain |