| Tag | Content |
|---|---|
| Uniprot ID | Q02591 |
| Entrez ID | 14836 |
| Genbank protein ID | AAA37826.1; CAA73611.1; CAA73612.1; |
| Genbank nucleotide ID | NM_010351.1 |
| Ensembl protein ID | ENSMUSP00000021513 |
| Ensembl nucleotide ID | ENSMUSG00000021095 |
| Gene name | Homeobox protein goosecoid |
| Gene symbol | Gsc |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | E12.5, E13.75, E13.5, E14.5, E15.5 |
| Data sources | Manually collected |
| Reference | 10512191; 7555726; 7555718; |
| Functional description | Regulates chordin (CHRD). May play a role in spatial programing within discrete embryonic fields or lineage compartments during organogenesis (By similarity). In concert with NKX3-2, plays a role in defining the structural components of the middle ear; required for the development of the entire tympanic ring. Goosecoid-expressing regions of the gastrulating mouse egg cylinder have organizer-like activity when transplanted into Xenopus embryos. Probably involved in the regulatory networks that define neural crest cell fate specification and determine mesoderm cell lineages in mammals (By similarity). |
| Sequence | MPASMFSIDN ILAARPRCKD AVLPVAPSAA APVVFPALHG DSLYGAGGGT SSDYGAFYPR 60 PVAPGGAGLP AAVGSSRLGY NSYFYGQLHV QAAPVGPACC GAVPPLGAQQ CSCVPTPPGY 120 EGPGSVLVSP VPHQMLPYMN VGTLSRTELQ LLNQLHCRRK RRHRTIFTDE QLEALENLFQ 180 ETKYPDVGTR EQLARKVHLR EEKVEVWFKN RRAKWRRQKR SSSEESENAE KWNKTSSKAS 240 PEKREEEGKS DLDSDS 256 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | GSC | 514862 | E1BB15 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | GSC | 102185957 | A0A452FMK4 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | GSC | 145258 | P56915 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Gsc | 14836 | Q02591 | CPO | E12.5, E13.75, E13.5, E14.5, E15.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | GSC | 467546 | A2T733 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | GSC | 397342 | F1SCC4 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | Gsc | 317715 | G3V7E7 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | gsc | Q7ZZR4 | Danio rerio | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding | IDA |
| GO:0001085 | RNA polymerase II transcription factor binding | IPI |
| GO:0001103 | RNA polymerase II repressing transcription factor binding | IPI |
| GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific | IDA |
| GO:0005515 | protein binding | IPI |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IGI |
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IDA |
| GO:0009653 | anatomical structure morphogenesis | IGI |
| GO:0014036 | neural crest cell fate specification | ISS |
| GO:0014036 | neural crest cell fate specification | ISO |
| GO:0021904 | dorsal/ventral neural tube patterning | IGI |
| GO:0023019 | signal transduction involved in regulation of gene expression | IDA |
| GO:0030178 | negative regulation of Wnt signaling pathway | IMP |
| GO:0030900 | forebrain development | IGI |
| GO:0042474 | middle ear morphogenesis | IMP |
| GO:0043583 | ear development | IMP |
| GO:0048644 | muscle organ morphogenesis | IMP |
| GO:0048704 | embryonic skeletal system morphogenesis | IMP |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005634 | nucleus | IEA |
| GO:0005667 | transcription factor complex | IDA |
| Reactome ID | Reactome Term | Evidence |
|---|
| Pfam ID | Pfam Term |
|---|---|
| PF00046 | Homeodomain |