Gene: SMO

Basic information

Tag Content
Uniprot ID A0A452FRY0
Entrez ID 102171572
Genbank protein ID
Genbank nucleotide ID XM_018046943.1
Ensembl protein ID ENSCHIP00000027079
Ensembl nucleotide ID ENSCHIG00000023137
Gene name Uncharacterized protein
Gene symbol SMO
Organism Capra hircus
NCBI taxa ID 9925
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MAAARLARGP ELLLLALLLL LGAPGRGAAL SGNATRPGPW SAGGSARRSA AVTGPPPLLS 60
HCGRAAPCEP LRYNVCLGSA LPYGATSTLL AGDSDSQEEA HGKLVLWSGL RNAPRCWAVI 120
QPLLCAVYMP KCENDRVELP SRTLCQATRG PCAIVERERG WPDFLRCTPD HFPEGCPNEV 180
QNIKFNSSGQ CEAPLVRTDN PKSWYEDVEG CGIQCQNPLF TEAEHQDMHS YIAAFGAVTG 240
LCTLFTLATF VADWRNSNRY PAVILFYVNA CFFVGSIGWL AQFMDGARRE IVCRADGTMR 300
LGEPTSNETL SCVIIFVIVY YALMAGVVWF VVLTYAWHTS FKALGTTYQP LSGKTSYFHL 360
LTWSLPFVLT VAILAVAQVD GDSVSGICFV GYKNYRYRAG FVLAPIGLVL IVGGYFLIRG 420
VMTLFSIKSN HPGLLSEKAA SKINETMLRL GIFGFLAFGF VLITFSCHFY DFFNQAEWER 480
SFRDYVLCQA NVTIGLPTKK PIPDCEIKNR PSLLVEKINL FAMFGTGISM STWVWTKATL 540
LIWRRTWCRL TGQSDDEPKR IKKSKMIAKA FSKRRELLQN PGQELSFSMH TVSHDGPVAG 600
LAFDLNEPSA DVSSAWAQHV TKMVARRGAI LPQDVSVTPV ATPVPPEEKA NLWLVEAEIS 660
PELEKRLGRK KKRRKRKKEV CPLVPPPELH LPALGPAPAP SAVPRLPQLP RQKCLVAAGA 720
WGPGESCRPG AWTLVSNPFC PEPSAPAPVA WAQGRRQGLG PIHSRTNLME AELMDADSDF 780

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologSMO539308E1BE57Bos taurusPredictionMore>>
1:1 orthologSMO102171572A0A452FRY0Capra hircusPredictionMore>>
1:1 orthologSMO6608Q99835Homo sapiensPredictionMore>>
1:1 orthologSmo319757P56726CPOE13.0, E14.5Mus musculusPublicationMore>>
1:1 orthologSMO100515110F1SMQ3Sus scrofaPredictionMore>>
1:1 orthologSmoG3V736Rattus norvegicusPredictionMore>>
1:1 orthologsmo30225Q5RH73Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0097731 9+0 non-motile cilium
GO:0005901 caveola
GO:0060170 ciliary membrane
GO:0005794 Golgi apparatus
GO:0016021 integral component of membrane
GO:0008144 drug binding
GO:0005113 patched binding
GO:0004888 transmembrane signaling receptor activity
GO:0009952 anterior/posterior pattern specification
GO:0048143 astrocyte activation
GO:0060413 atrial septum morphogenesis
GO:0001708 cell fate specification
GO:0071397 cellular response to cholesterol
GO:0021953 central nervous system neuron differentiation
GO:0021696 cerebellar cortex morphogenesis
GO:0021987 cerebral cortex development
GO:0060242 contact inhibition
GO:0021542 dentate gyrus development
GO:0003140 determination of left/right asymmetry in lateral mesoderm
GO:0021904 dorsal/ventral neural tube patterning
GO:0060684 epithelial-mesenchymal cell signaling
GO:0048853 forebrain morphogenesis
GO:0031069 hair follicle morphogenesis
GO:0001947 heart looping
GO:0048873 homeostasis of number of cells within a tissue
GO:0001701 in utero embryonic development
GO:0070986 left/right axis specification
GO:0060644 mammary gland epithelial cell differentiation
GO:0072285 mesenchymal to epithelial transition involved in metanephric renal vesicle formation
GO:0007494 midgut development
GO:0035264 multicellular organism growth
GO:0051451 myoblast migration
GO:0043066 negative regulation of apoptotic process
GO:0043392 negative regulation of DNA binding
GO:0030857 negative regulation of epithelial cell differentiation
GO:0051799 negative regulation of hair follicle development
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0001755 neural crest cell migration
GO:0042475 odontogenesis of dentin-containing tooth
GO:0001649 osteoblast differentiation
GO:0061113 pancreas morphogenesis
GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis
GO:0030335 positive regulation of cell migration
GO:0050679 positive regulation of epithelial cell proliferation
GO:0007228 positive regulation of hh target transcription factor activity
GO:0002053 positive regulation of mesenchymal cell proliferation
GO:0040018 positive regulation of multicellular organism growth
GO:0002052 positive regulation of neuroblast proliferation
GO:0046622 positive regulation of organ growth
GO:0042307 positive regulation of protein import into nucleus
GO:0045880 positive regulation of smoothened signaling pathway
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0034504 protein localization to nucleus
GO:0050821 protein stabilization
GO:2000826 regulation of heart morphogenesis
GO:2000036 regulation of stem cell population maintenance
GO:0048741 skeletal muscle fiber development
GO:0048745 smooth muscle tissue development
GO:0021938 smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation
GO:0021910 smoothened signaling pathway involved in ventral spinal cord patterning
GO:0061053 somite development
GO:0021794 thalamus development
GO:0003323 type B pancreatic cell development
GO:0001570 vasculogenesis
GO:0007371 ventral midline determination

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0217 Developmental protein
KW-1015 Disulfide bond
KW-0472 Membrane
KW-0675 Receptor
KW-1185 Reference proteome
KW-0732 Signal
KW-0812 Transmembrane
KW-1133 Transmembrane helix

Interpro

InterPro ID InterPro Term
IPR015526 Frizzled/SFRP
IPR000539 Frizzled/Smoothened_TM
IPR020067 Frizzled_dom
IPR036790 Frizzled_dom_sf
IPR017981 GPCR_2-like
IPR026544 SMO
IPR041771 SMO_CRD

PROSITE

PROSITE ID PROSITE Term
PS50038 FZ
PS50261 G_PROTEIN_RECEP_F2_4

Pfam

Pfam ID Pfam Term
PF01534 Frizzled
PF01392 Fz