| Tag | Content |
|---|---|
| Uniprot ID | Q5RH73 |
| Entrez ID | 30225 |
| Genbank protein ID | |
| Genbank nucleotide ID | NM_131027.2 |
| Ensembl protein ID | ENSDARP00000013486 |
| Ensembl nucleotide ID | ENSDARG00000002952 |
| Gene name | Smoothened, frizzled class receptor |
| Gene symbol | smo |
| Organism | Danio rerio |
| NCBI taxa ID | 7955 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MSSKRPCSIV GSFWMLWIWT ATSMVARAVI LHPNETIFND FCKKSTTCEV LKYNTCLGSP 60 LPYTHTSLIL AEDSETQEEA FEKLAMWSGL RNAPRCWAVI QPLLCAVYMP KCENGKVELP 120 SQHLCQATRN PCSIVERERG WPNFLKCENK EQFPKGCQNE VQKLKFNTSG QCEAPLVKTD 180 IQASWYKDVE GCGIQCDNPL FTEDEHSDMH SYIAVFGTIT LLCTFFTLAT FLADWKNSNR 240 YPAVILFYVN ACFFIGSIGW LAQFMDGARN EIVCKSDNTM RLGEPSSTET LSCVIIFVIV 300 YYSLMSGVIW FVMLTYAWHT SFKALGTTHQ PLSGKTSYFH LVTWSIPFIL TVAILANSQV 360 DADSVSGICF VGYRYYEYRA GFVLAPIGFV LVIGGYFLIR GVMTLFSIKS NHPGLLSEKA 420 ASKINETMLR LGIFGFLAFG FVLITFGCHF YDFFNQAEWE RSFREYVLCE ANVTIAHQTN 480 KPIPECAIKN RPSLLVGKIN LFSMFGTGIA MSTWVWTKAT ILIWKRTWFR IIGRSDDEPK 540 RIKKSKMIAK AFSKRKELQK DPEKELSFSM HTVSHEGPVA GINFDLNEPS IEMSSAWAQH 600 VTKMVARRGA ILPQDISVTP TGTPIPPPEE RNKLWMVEAE ISPEMMKRKK KKKKRRKEVR 660 PAGPAADEGN PAYHRREFGP SAVPRLPKLP GHRSLVANLW EQQRQQQEEQ DMLPGAFPEF 720 RPSCPLPYQD RYGGLGYLRN KPSSLPLANP LTLRDSMQGD LSHFQQSSWQ PKGVFRHLGQ 780 EASMMDVGRT AVVPRADGRR GVQIHSRTNL MDAELLDADS DF 822 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | SMO | 539308 | E1BE57 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | SMO | 102171572 | A0A452FRY0 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | SMO | 6608 | Q99835 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Smo | 319757 | P56726 | CPO | E13.0, E14.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | SMO | 100515110 | F1SMQ3 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | Smo | G3V736 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | smo | 30225 | Q5RH73 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005929 | cilium |
| GO:0030425 | dendrite |
| GO:0016021 | integral component of membrane |
| GO:0005886 | plasma membrane |
| GO:0004930 | G protein-coupled receptor activity |
| GO:0008142 | oxysterol binding |
| GO:0005113 | patched binding |
| GO:0021984 | adenohypophysis development |
| GO:0035479 | angioblast cell migration from lateral mesoderm to midline |
| GO:0009952 | anterior/posterior pattern specification |
| GO:0060844 | arterial endothelial cell fate commitment |
| GO:0007411 | axon guidance |
| GO:0003231 | cardiac ventricle development |
| GO:0010002 | cardioblast differentiation |
| GO:0051216 | cartilage development |
| GO:0035143 | caudal fin morphogenesis |
| GO:0007417 | central nervous system development |
| GO:0021587 | cerebellum morphogenesis |
| GO:0060830 | ciliary receptor clustering involved in smoothened signaling pathway |
| GO:0071679 | commissural neuron axon guidance |
| GO:0021536 | diencephalon development |
| GO:0035912 | dorsal aorta morphogenesis |
| GO:0031076 | embryonic camera-type eye development |
| GO:0048557 | embryonic digestive tract morphogenesis |
| GO:0048702 | embryonic neurocranium morphogenesis |
| GO:0009880 | embryonic pattern specification |
| GO:0048703 | embryonic viscerocranium morphogenesis |
| GO:0060956 | endocardial cell differentiation |
| GO:0031018 | endocrine pancreas development |
| GO:0035270 | endocrine system development |
| GO:0072175 | epithelial tube formation |
| GO:0031017 | exocrine pancreas development |
| GO:0021508 | floor plate formation |
| GO:0030900 | forebrain development |
| GO:0021798 | forebrain dorsal/ventral pattern formation |
| GO:0021782 | glial cell development |
| GO:0021986 | habenula development |
| GO:0001947 | heart looping |
| GO:0030902 | hindbrain development |
| GO:0048839 | inner ear development |
| GO:0042472 | inner ear morphogenesis |
| GO:0042693 | muscle cell fate commitment |
| GO:0007517 | muscle organ development |
| GO:0030239 | myofibril assembly |
| GO:0007399 | nervous system development |
| GO:0014033 | neural crest cell differentiation |
| GO:0001839 | neural plate morphogenesis |
| GO:0060896 | neural plate pattern specification |
| GO:0030182 | neuron differentiation |
| GO:0048663 | neuron fate commitment |
| GO:0014003 | oligodendrocyte development |
| GO:0032474 | otolith morphogenesis |
| GO:0031016 | pancreas development |
| GO:0045880 | positive regulation of smoothened signaling pathway |
| GO:0060041 | retina development in camera-type eye |
| GO:0031290 | retinal ganglion cell axon guidance |
| GO:0048752 | semicircular canal morphogenesis |
| GO:0048741 | skeletal muscle fiber development |
| GO:0048745 | smooth muscle tissue development |
| GO:0007224 | smoothened signaling pathway |
| GO:0021523 | somatic motor neuron differentiation |
| GO:0061053 | somite development |
| GO:0021520 | spinal cord motor neuron cell fate specification |
| GO:0021522 | spinal cord motor neuron differentiation |
| GO:0055002 | striated muscle cell development |
| GO:0048794 | swim bladder development |
| GO:0048795 | swim bladder morphogenesis |
| GO:0021537 | telencephalon development |
| GO:0001570 | vasculogenesis |