| Tag | Content |
|---|---|
| Uniprot ID | E1BE57 |
| Entrez ID | 539308 |
| Genbank protein ID | |
| Genbank nucleotide ID | NM_001192220.1 |
| Ensembl protein ID | ENSBTAP00000017670 |
| Ensembl nucleotide ID | ENSBTAG00000013287 |
| Gene name | Smoothened, frizzled class receptor |
| Gene symbol | SMO |
| Organism | Bos taurus |
| NCBI taxa ID | 9913 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MAAARLARGP ELLLLGLLLL LGGPGRGAAL SGNATRPGPW SAGGSARRSA AVTGPPPLLS 60 HCGRAAPCEP LRYNVCLGSA LPYGATSTLL AGDSDSQEEA HGKLVLWSGL RNAPRCWAVI 120 QPLLCAVYMP KCENDRVELP SRTLCQATRG PCAIVERERG WPDFLRCTPD HFPEGCPNEV 180 QNIKFNSSGQ CEAPLVRTDN PKSWYEDVEG CGIQCQNPLF TEAEHQDMHS YIAAFGAVTG 240 LCTLFTLATF VADWRNSNRY PAVILFYVNA CFFVGSIGWL AQFMDGARRE IVCRADGTMR 300 LGEPTSNETL SCVIIFVIVY YALMAGVVWF VVLTYAWHTS FKALGTTYQP LSGKTSYFHL 360 LTWSLPFVLT VAILAVAQVD GDSVSGICFV GYKNYRYRAG FVLAPIGLVL IVGGYFLIRG 420 VMTLFSIKSN HPGLLSEKAA SKINETMLRL GIFGFLAFGF VLITFSCHFY DFFNQAEWER 480 SFRDYVLCQA NVTIGLPTKK PIPDCEIKNR PSLLVEKINL FAMFGTGISM STWVWTKATL 540 LIWRRTWCRL TGQSDDEPKR IKKSKMIAKA FSKRRELLQN PGQELSFSMH TVSHDGPVAG 600 LAFDLNEPSA DVSSAWAQHV TKMVARRGAI LPQDVSVTPV ATPVPPEEKA NLWLVEAEIS 660 PELEKRLGRK KKRRKRKKEV CPLVPPPELH LPALGPASAS SAVPRLPQLP RQKCLVAAGA 720 WGPGESCRPG AWTLVSNPFC PEPSAPAPVA WAQGRRQGLG PIHSRTNLME AELMDADSDF 780 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | SMO | 539308 | E1BE57 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | SMO | 102171572 | A0A452FRY0 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | SMO | 6608 | Q99835 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Smo | 319757 | P56726 | CPO | E13.0, E14.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | SMO | 100515110 | F1SMQ3 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | Smo | G3V736 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | smo | 30225 | Q5RH73 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0097731 | 9+0 non-motile cilium |
| GO:0005901 | caveola |
| GO:0060170 | ciliary membrane |
| GO:0005929 | cilium |
| GO:0030425 | dendrite |
| GO:0005794 | Golgi apparatus |
| GO:0016021 | integral component of membrane |
| GO:0005886 | plasma membrane |
| GO:0008144 | drug binding |
| GO:0005113 | patched binding |
| GO:0004888 | transmembrane signaling receptor activity |
| GO:0009952 | anterior/posterior pattern specification |
| GO:0048143 | astrocyte activation |
| GO:0060413 | atrial septum morphogenesis |
| GO:0001708 | cell fate specification |
| GO:0071397 | cellular response to cholesterol |
| GO:0007417 | central nervous system development |
| GO:0021953 | central nervous system neuron differentiation |
| GO:0021696 | cerebellar cortex morphogenesis |
| GO:0021987 | cerebral cortex development |
| GO:0071679 | commissural neuron axon guidance |
| GO:0060242 | contact inhibition |
| GO:0021542 | dentate gyrus development |
| GO:0003140 | determination of left/right asymmetry in lateral mesoderm |
| GO:0021904 | dorsal/ventral neural tube patterning |
| GO:0060684 | epithelial-mesenchymal cell signaling |
| GO:0048853 | forebrain morphogenesis |
| GO:0031069 | hair follicle morphogenesis |
| GO:0001947 | heart looping |
| GO:0048873 | homeostasis of number of cells within a tissue |
| GO:0001701 | in utero embryonic development |
| GO:0070986 | left/right axis specification |
| GO:0060644 | mammary gland epithelial cell differentiation |
| GO:0072285 | mesenchymal to epithelial transition involved in metanephric renal vesicle formation |
| GO:0007494 | midgut development |
| GO:0035264 | multicellular organism growth |
| GO:0051451 | myoblast migration |
| GO:0043066 | negative regulation of apoptotic process |
| GO:0043392 | negative regulation of DNA binding |
| GO:0030857 | negative regulation of epithelial cell differentiation |
| GO:0051799 | negative regulation of hair follicle development |
| GO:0000122 | negative regulation of transcription by RNA polymerase II |
| GO:0001755 | neural crest cell migration |
| GO:0042475 | odontogenesis of dentin-containing tooth |
| GO:0001649 | osteoblast differentiation |
| GO:0061113 | pancreas morphogenesis |
| GO:0090190 | positive regulation of branching involved in ureteric bud morphogenesis |
| GO:0030335 | positive regulation of cell migration |
| GO:0050679 | positive regulation of epithelial cell proliferation |
| GO:0007228 | positive regulation of hh target transcription factor activity |
| GO:0002053 | positive regulation of mesenchymal cell proliferation |
| GO:0040018 | positive regulation of multicellular organism growth |
| GO:0002052 | positive regulation of neuroblast proliferation |
| GO:0046622 | positive regulation of organ growth |
| GO:0042307 | positive regulation of protein import into nucleus |
| GO:0045880 | positive regulation of smoothened signaling pathway |
| GO:0045944 | positive regulation of transcription by RNA polymerase II |
| GO:0034504 | protein localization to nucleus |
| GO:0050821 | protein stabilization |
| GO:2000826 | regulation of heart morphogenesis |
| GO:2000036 | regulation of stem cell population maintenance |
| GO:0048741 | skeletal muscle fiber development |
| GO:0048745 | smooth muscle tissue development |
| GO:0007224 | smoothened signaling pathway |
| GO:0021938 | smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation |
| GO:0021910 | smoothened signaling pathway involved in ventral spinal cord patterning |
| GO:0061053 | somite development |
| GO:0021794 | thalamus development |
| GO:0003323 | type B pancreatic cell development |
| GO:0001570 | vasculogenesis |
| GO:0007371 | ventral midline determination |