| Tag | Content |
|---|---|
| Uniprot ID | A0A452G0I6 |
| Entrez ID | |
| Genbank protein ID | |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSCHIP00000029941 |
| Ensembl nucleotide ID | ENSCHIG00000024881 |
| Gene name | Nitric oxide synthase-interacting protein |
| Gene symbol | NOSIP |
| Organism | Capra hircus |
| NCBI taxa ID | 9925 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity. |
| Sequence | MTRHGKNCTA GAVYTYHEKK KDTAASGYGT QNIRLSRDAV KDFDCCCLSL QPCHDPVVTP 60 DGYLYEREAI LEYILHQKKE IARQMKAYEK QRGARREEQK ELQRAAAQDH VRGFLEKEAA 120 IVSRPLNPFT PKAASAGNGP DDAQPGSSAG PAGKDKDKAL PSFWIPSLTP EAKATKLEKP 180 APSPSSHHLS RIVTCPMSGK PLRMSDLTPV RFTPLDSSVD RVGLITRSER YVCAVTRDSL 240 SNATPCAVLR PSGAVVTLEC VEKLIRKDMV DPVTGEKLTD RDIIVLQRLG NPPGTGGTGF 300 AGSGVKLQAE KSRPVMQA 318 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | NOSIP | 511234 | Q3SWY5 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | NOSIP | E2R5E4 | Canis lupus familiaris | Prediction | More>> | |||
| 1:1 ortholog | NOSIP | A0A452G0I6 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | NOSIP | 100052038 | F6SN22 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | NOSIP | 51070 | A0A075B6F9 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Nosip | 66394 | Q9D6T0 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | NOSIP | 456209 | H2QGV5 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | 100518311 | A0A4X1VYM4 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Nosip | 292894 | D3ZH12 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | nosip | 492793 | Q5U3S7 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005737 | cytoplasm |
| GO:0005654 | nucleoplasm |
| GO:0061630 | ubiquitin protein ligase activity |
| Pfam ID | Pfam Term |
|---|---|
| PF15906 | zf-NOSIP |