| Tag | Content |
|---|---|
| Uniprot ID | Q5U3S7 |
| Entrez ID | 492793 |
| Genbank protein ID | AAH85409.1 |
| Genbank nucleotide ID | NM_001007434.1; XM_009299536.2; XM_005164022.3; |
| Ensembl protein ID | ENSDARP00000139361; ENSDARP00000157364; ENSDARP00000055311; |
| Ensembl nucleotide ID | ENSDARG00000112335; ENSDARG00000037958; |
| Gene name | Nitric oxide synthase-interacting protein |
| Gene symbol | nosip |
| Organism | Danio rerio |
| NCBI taxa ID | 7955 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | E3 ubiquitin-protein ligase that is essential for proper development of the forebrain, the eye, and the face (By similarity). Negatively regulates nitric oxide production by inducing nitric oxide synthase translocation to actin cytoskeleton and inhibiting its enzymatic activity (By similarity). |
| Sequence | MTRHGKNCTA GAVYTYHEKR KDTAASGYGT QSVRLGKDAI KDFDCCSLSL QPCRDPVLTE 60 DGYLYEKEAI LQYILHQKTE IAKKMKAYEK QKQALKSEGQ LESKSEERER AEKFKQRENN 120 IVSKPINPFT SGKSKDEGNQ NGSTSSSSTD TSSGESSSSS ALPSFWIPSL TPEAKPTLLK 180 KPSKTVSCPM SGRPLKMSDL ITVRFTPLDP SLDRVALLTR QDRYVCAVTK DTLGNSVPCA 240 VLRPSGVVVT MECVEKLIKK DMVDPITGDK LKEKDIIPIQ RGGTGFAGSG VDLKAKEARP 300 VMQA 304 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | NOSIP | 511234 | Q3SWY5 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | NOSIP | E2R5E4 | Canis lupus familiaris | Prediction | More>> | |||
| 1:1 ortholog | NOSIP | A0A452G0I6 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | NOSIP | 100052038 | F6SN22 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | NOSIP | 51070 | A0A075B6F9 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Nosip | 66394 | Q9D6T0 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | NOSIP | 456209 | H2QGV5 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | 100518311 | A0A4X1VYM4 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Nosip | 292894 | D3ZH12 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | nosip | 492793 | Q5U3S7 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005737 | cytoplasm |
| GO:0005634 | nucleus |
| GO:0061630 | ubiquitin protein ligase activity |
| GO:0007275 | multicellular organism development |
| Pfam ID | Pfam Term |
|---|---|
| PF15906 | zf-NOSIP |