Gene: Nosip

Basic information

Tag Content
Uniprot ID Q9D6T0; Q9D8J9;
Entrez ID 66394
Genbank protein ID BAB25373.1; BAB26637.1; AAH89029.1;
Genbank nucleotide ID XM_017312232.1; NM_025533.3; NM_001163684.1;
Ensembl protein ID ENSMUSP00000103460; ENSMUSP00000003513;
Ensembl nucleotide ID ENSMUSG00000003421
Gene name Nitric oxide synthase-interacting protein
Gene symbol Nosip
Organism Mus musculus
NCBI taxa ID 10090
Cleft type CPO
Developmental stage
Data sources Manually collected
Reference 25546391
Functional description E3 ubiquitin-protein ligase that is essential for proper development of the forebrain, the eye and the face. Catalyzes monoubiquitination of serine/threonine-protein phosphatase 2A (PP2A) catalytic subunit PPP2CA/PPP2CB (PubMed:25546391). Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity (By similarity).
Sequence
MTRHGKNCTA GAVYTYHEKK KDTAASGYGT QNIRLSRDAV KDFDCCCLSL QPCHDPVVTP 60
DGYLYEREAI LEYILHQKRE IARQVKAYEK QRGARREEQK ELQRAAAQDQ VRGFLEKEAA 120
IVSRPLNPFM PKAATLPNTE GEQPGPSVGP VGKDKDKALP SFWIPSLTPE AKATKLEKPS 180
RTVTCPMSGK PLRMSDLTSV RFTQLDDSVD RVGLITRSER YVCAVTRDSL SNATPCAVLR 240
PSGAVVTLEC VEKLIRKDMV DPVNGDTLTE RDIIVLQRGG TGFAGSGVKL QAEMSRPVMQ 300
A 301

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologNOSIP511234Q3SWY5Bos taurusPredictionMore>>
1:1 orthologNOSIPE2R5E4Canis lupus familiarisPredictionMore>>
1:1 orthologNOSIPA0A452G0I6Capra hircusPredictionMore>>
1:1 orthologNOSIP100052038F6SN22Equus caballusPredictionMore>>
1:1 orthologNOSIP51070A0A075B6F9Homo sapiensPredictionMore>>
1:1 orthologNosip66394Q9D6T0CPOMus musculusPublicationMore>>
1:1 orthologNOSIP456209H2QGV5Pan troglodytesPredictionMore>>
1:1 ortholog100518311A0A4X1VYM4Sus scrofaPredictionMore>>
1:1 orthologNosip292894D3ZH12Rattus norvegicusPredictionMore>>
1:1 ortholognosip492793Q5U3S7Danio rerioPredictionMore>>

Other genetic variants/mutations

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Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID GO Term Evidence
GO:0061630 ubiquitin protein ligase activityIEA

GO:Biological Process

GO ID GO Term Evidence
GO:0007275 multicellular organism developmentIEA
GO:0016567 protein ubiquitinationIEA
GO:0043086 negative regulation of catalytic activityISO
GO:0051001 negative regulation of nitric-oxide synthase activityISO

GO:Cellular Component

GO ID GO Term Evidence
GO:0005634 nucleusISO
GO:0005634 nucleusIBA
GO:0005654 nucleoplasmISO
GO:0005737 cytoplasmISO

Reactome Pathway

Reactome ID Reactome Term Evidence
R-MMU-1430728 MetabolismIEA
R-MMU-202131 Metabolism of nitric oxide: eNOS activation and regulationIEA
R-MMU-203754 NOSIP mediated eNOS traffickingIEA

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0025 Alternative splicing
KW-0963 Cytoplasm
KW-0217 Developmental protein
KW-0539 Nucleus
KW-0597 Phosphoprotein
KW-1185 Reference proteome
KW-0808 Transferase
KW-0833 Ubl conjugation pathway

Interpro

InterPro ID InterPro Term
IPR016818 NOSIP
IPR031790 Znf-NOSIP
IPR013083 Znf_RING/FYVE/PHD

PROSITE

PROSITE ID PROSITE Term

Pfam

Pfam ID Pfam Term
PF15906 zf-NOSIP

Protein-protein interaction

Protein-miRNA interaction