| Tag | Content |
|---|---|
| Uniprot ID | D3ZH12 |
| Entrez ID | 292894 |
| Genbank protein ID | EDM07418.1 |
| Genbank nucleotide ID | NM_001106260.1; XM_006229026.3; XM_006229025.1; |
| Ensembl protein ID | ENSRNOP00000027882; ENSRNOP00000069533; |
| Ensembl nucleotide ID | ENSRNOG00000020543 |
| Gene name | Nitric oxide synthase-interacting protein |
| Gene symbol | Nosip |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity. |
| Sequence | MTRHGKNCTA GAVYTYHEKK KDTAASGYGT QNIRLSRDAV KDFDCCCLSL QPCHDPVVTP 60 DGYLYEREAI LEYILHQKRE IARQMKAYEK QRGARREEQK ELQRAAAQDQ VRGFLEKESA 120 IVSRPLNPFM PKAATLPNTD GEQPGPSVGP LGKDKDKALP SFWIPSLTPE AKATKLEKPS 180 RTVTCPMSGK PLRMSDLTSV RFTQLDDSVD RVGLITRSER YVCAVTRDSL SNATPCAVLR 240 PSGAVVTLEC VEKLIRKDMV DPVNGDTLTE RDIIVLQRGG TGFAGSGVKL QAEMSRPVMQ 300 A 301 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | NOSIP | 511234 | Q3SWY5 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | NOSIP | E2R5E4 | Canis lupus familiaris | Prediction | More>> | |||
| 1:1 ortholog | NOSIP | A0A452G0I6 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | NOSIP | 100052038 | F6SN22 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | NOSIP | 51070 | A0A075B6F9 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Nosip | 66394 | Q9D6T0 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | NOSIP | 456209 | H2QGV5 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | 100518311 | A0A4X1VYM4 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Nosip | 292894 | D3ZH12 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | nosip | 492793 | Q5U3S7 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005737 | cytoplasm |
| GO:0005654 | nucleoplasm |
| GO:0005634 | nucleus |
| GO:0061630 | ubiquitin protein ligase activity |
| GO:0043086 | negative regulation of catalytic activity |
| GO:0051001 | negative regulation of nitric-oxide synthase activity |
| Pfam ID | Pfam Term |
|---|---|
| PF15906 | zf-NOSIP |