| Tag | Content |
|---|---|
| Uniprot ID | A2VDM5 |
| Entrez ID | 338068 |
| Genbank protein ID | AAI33312.1 |
| Genbank nucleotide ID | NM_176663.3 |
| Ensembl protein ID | |
| Ensembl nucleotide ID | |
| Gene name | Serine/threonine-protein kinase receptor |
| Gene symbol | ACVR1 |
| Organism | Bos taurus |
| NCBI taxa ID | 9913 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MVDGVMILPV LVMIAFPSPS MEDEKPKVNP KLYMCVCEGL SCGDEAHCEG QQCFSSLSIN 60 DGFHVYQKGC FQVYEQGKMT CKTPPSPGQA VECCQGDWCN RNITAQLPTK GKSFPGTQNF 120 HLEVGLIILS VVFAVCLLAC LLGVALRKFK RRNQERLNPR DVEYGTIEGL ITTNVGDSTL 180 ADLLDHSCTS GSGSGLPFLV QRTVARQITL LECVGKGRYG EVWRGSWQGE NVAVKIFSSR 240 DEKSWFRETE LYNTVMLRHE NILGFIASDM TSRHSSTQLW LITHYHEMGS LYDYLQLTTL 300 DTVSCLRIVL SIASGLAHLH IEIFGTQGKP AIAHRDLKSK NILVKKNGQC CIADLGLAVM 360 HSQSTNQLDV GNNPRVGTKR YMAPEVLDET IQVDCFDSYK RVDIWAFGLV LWEVARRMVS 420 NGIVEDYKPP FYDVVPNDPS FEDMRKVVCV DQQRPNIPNR WFSDPTLTSL AKLMKECWYQ 480 NPSARLTALR IKKTLTKIDN SLDKLKTDC 509 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | ACVR1 | 338068 | A2VDM5 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | ACVR1 | E2RKJ3 | Canis lupus familiaris | Prediction | More>> | |||
| 1:1 ortholog | ACVR1 | A0A452FPW1 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | ACVR1 | 100050899 | F7B4G7 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | ACVR1 | 90 | Q04771 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Acvr1 | 11477 | P37172 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | ACVR1 | A0A2I3RBB9 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | ACVR1 | 100152307 | E9M2M1 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | ACVR1 | 100355119 | G1SHK1 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Acvr1 | 79558 | A0A0G2K2P7 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0070724 | BMP receptor complex |
| GO:0005886 | plasma membrane |
| GO:0043235 | receptor complex |
| GO:0005524 | ATP binding |
| GO:0046872 | metal ion binding |
| GO:0004674 | protein serine/threonine kinase activity |
| GO:0005025 | transforming growth factor beta receptor activity, type I |
| GO:0001525 | angiogenesis |
| GO:0030509 | BMP signaling pathway |
| GO:0071363 | cellular response to growth factor stimulus |
| GO:0007507 | heart development |
| GO:0006468 | protein phosphorylation |
| GO:0007179 | transforming growth factor beta receptor signaling pathway |