| Tag | Content |
|---|---|
| Uniprot ID | E2RKJ3 |
| Entrez ID | |
| Genbank protein ID | |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSCAFP00000013675 |
| Ensembl nucleotide ID | ENSCAFG00000009287 |
| Gene name | Serine/threonine-protein kinase receptor |
| Gene symbol | ACVR1 |
| Organism | Canis lupus familiaris |
| NCBI taxa ID | 9615 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MVDGVMMLPV LMMIAFPSPS MEDEKPKKGC FQVYEQGKMT CKTPPSPGQA VECCQGDWCN 60 RNITAQLPTK GKSFPETQNF HLEVGLIILS VVFAVCLLAC LLGVALRKFK RRNQERLNPR 120 DVEYGTIEGL ITTNVGDSTL ADLLDHSCTS GSGSGLPFLV QRTVARQITL LECVGKGRYG 180 EVWRGSWQGE NVAVKIFSSR DEKSWFRETE LYNTVMLRHE NILGFIASDM TSRHSSTQLW 240 LITHYHEMGS LYDYLQLTTL DTVSCLRIVL SIASGLAHLH IEIFGTQGKP AIAHRDLKSK 300 NILVKKNGQC CIADLGLAVM HSQSTNQLDV GNNPRVGTKR YMAPEVLDET IQVDCFDSYK 360 RVDIWAFGLV LWEVARRMVS NGIVEDYKPP FYDVVPNDPS FEDMRKVVCV DQQRPNIPNR 420 WFSDPTLTSL AKLMKECWYQ NPSARLTALR IKKTLTKIDN SLDKLKTDC 469 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | ACVR1 | 338068 | A2VDM5 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | ACVR1 | E2RKJ3 | Canis lupus familiaris | Prediction | More>> | |||
| 1:1 ortholog | ACVR1 | A0A452FPW1 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | ACVR1 | 100050899 | F7B4G7 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | ACVR1 | 90 | Q04771 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Acvr1 | 11477 | P37172 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | ACVR1 | A0A2I3RBB9 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | ACVR1 | 100152307 | E9M2M1 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | ACVR1 | 100355119 | G1SHK1 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Acvr1 | 79558 | A0A0G2K2P7 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0070724 | BMP receptor complex |
| GO:0005886 | plasma membrane |
| GO:0043235 | receptor complex |
| GO:0005524 | ATP binding |
| GO:0046872 | metal ion binding |
| GO:0004674 | protein serine/threonine kinase activity |
| GO:0005025 | transforming growth factor beta receptor activity, type I |
| GO:0001525 | angiogenesis |
| GO:0030509 | BMP signaling pathway |
| GO:0071363 | cellular response to growth factor stimulus |
| GO:0007507 | heart development |
| GO:0006468 | protein phosphorylation |
| GO:0007179 | transforming growth factor beta receptor signaling pathway |
| Keyword ID | Keyword Term |
|---|---|
| KW-0067 | ATP-binding |
| KW-0418 | Kinase |
| KW-0460 | Magnesium |
| KW-0464 | Manganese |
| KW-0472 | Membrane |
| KW-0479 | Metal-binding |
| KW-0547 | Nucleotide-binding |
| KW-0675 | Receptor |
| KW-1185 | Reference proteome |
| KW-0723 | Serine/threonine-protein kinase |
| KW-0732 | Signal |
| KW-0808 | Transferase |
| KW-0812 | Transmembrane |
| KW-1133 | Transmembrane helix |