| Tag | Content |
|---|---|
| Uniprot ID | A5PMV8 |
| Entrez ID | |
| Genbank protein ID | |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSDARP00000028001 |
| Ensembl nucleotide ID | ENSDARG00000002330 |
| Gene name | LIM homeobox 8a |
| Gene symbol | lhx8a |
| Organism | Danio rerio |
| NCBI taxa ID | 7955 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MYWKNEQTTS KESPSKNTAK TQDLFEEVSC SSSLSLSPSS SPHTMTKKAI CTSCGTEIVD 60 KYLLKVNDMC WHVRCLSCSV CQTSLGRHIS CYIKEKEIFC KLDYFRKYGT RCAHCGRNIH 120 SNDWVRRAKG NTYHLACFAC FSCKRQLSTG EEFALVDERV LCRVHYDCML DNLKRAMENG 180 KGVNVEGAVP SEQEVNQPKP AKRARTSFTA DQLQVMQAQF AQDNNPDAQT LQKLAERTGL 240 SRRVIQVWFQ NCRARHKKHV SPNHSSAAPV SSLQSAHLSP PLIDELQYTA FAPVDTPMLT 300 ALHSYMDVHS PTSLVLQPLL PHSMTQLPIS HA 332 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | LHX8 | 431707 | Q68G74 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Lhx8 | 16875 | O35652 | CPO | E14.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | LHX8 | 469353 | H2R2T0 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | Lhx8 | 365963 | G3V6V6 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | lhx8a | A5PMV8 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005634 | nucleus |
| GO:0003700 | DNA-binding transcription factor activity |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO:0046872 | metal ion binding |
| GO:0000977 | RNA polymerase II transcription regulatory region sequence-specific DNA binding |
| GO:0021884 | forebrain neuron development |
| GO:0030182 | neuron differentiation |
| GO:0006357 | regulation of transcription by RNA polymerase II |