| Tag | Content |
|---|---|
| Uniprot ID | G3V6V6; Q5FVG3; |
| Entrez ID | 365963 |
| Genbank protein ID | AAH90011.1 |
| Genbank nucleotide ID | NM_001012219.1 |
| Ensembl protein ID | ENSRNOP00000009370 |
| Ensembl nucleotide ID | ENSRNOG00000028348 |
| Gene name | LIM homeobox 8 |
| Gene symbol | Lhx8 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MSEECGRPAA LAAGRTRKGA GEEGLVNPEG AGDEDSCSSS APLSPSSSPQ SMASGSVCPP 60 GKCVCSSCGL EIVDKYLLKV NDLCWHVRCL SCSVCRTSLG RHTSCYIKDK DIFCKLDYFR 120 RYGTRCSRCG RHIHSTDWVR RAKGNVYHLA CFACFSCKRQ LSTGEEFALV EEKVLCRVHF 180 DCMLDNLKRE VENGNGISVE GALLTEQDVN HPKPAKRART SFTADQLQVM QAQFAQDNNP 240 DAQTLQKLAE RTGLSRRVIQ VWFQNCRARH KKHVSPNHSS SAPVTAVPSS RLSPPMLEEM 300 AYSAYVPQDG TMLTALHSYM DAHQQLLDSS PCYPIQ 336 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | LHX8 | 431707 | Q68G74 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Lhx8 | 16875 | O35652 | CPO | E14.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | LHX8 | 469353 | H2R2T0 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | Lhx8 | 365963 | G3V6V6 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | lhx8a | A5PMV8 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0001674 | female germ cell nucleus |
| GO:0005634 | nucleus |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO:0046872 | metal ion binding |
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding |
| GO:0008585 | female gonad development |
| GO:0021884 | forebrain neuron development |
| GO:0021879 | forebrain neuron differentiation |
| GO:0007611 | learning or memory |
| GO:0030182 | neuron differentiation |
| GO:0042475 | odontogenesis of dentin-containing tooth |
| GO:0045944 | positive regulation of transcription by RNA polymerase II |