| Tag | Content |
|---|---|
| Uniprot ID | O35652; O70163; O88707; Q3TMT2; |
| Entrez ID | 16875 |
| Genbank protein ID | EDL11894.1; AAI25284.1; AAI25282.1; BAA28628.1; CAA04012.1; BAE38359.1; BAA21649.1; AAI44769.1; |
| Genbank nucleotide ID | NM_010713.2 |
| Ensembl protein ID | ENSMUSP00000136047 |
| Ensembl nucleotide ID | ENSMUSG00000096225 |
| Gene name | LIM/homeobox protein Lhx8 |
| Gene symbol | Lhx8 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | E14.5 |
| Data sources | Manually collected |
| Reference | 10611327; 19591819; 15217369; |
| Functional description | Transcription factor involved in differentiation of certain neurons and mesenchymal cells. |
| Sequence | MYWKSDQMFV CKLEGKEVPE LAVPREKCPG LMSEECGRPA ALAAGRTRKG AGEEGLVNPE 60 GAGDEDSCSS SAPLSPSSSP QSMASGSVCP PGKCVCSSCG LEIVDKYLLK VNDLCWHVRC 120 LSCSVCRTSL GRHTSCYIKD KDIFCKLDYF RRYGTRCSRC GRHIHSTDWV RRAKGNVYHL 180 ACFACFSCKR QLSTGEEFAL VEEKVLCRVH FDCMLDNLKR EVENGNGISV EGALLTEQDV 240 NHPKPAKRAR TSFTADQLQV MQAQFAQDNN PDAQTLQKLA ERTGLSRRVI QVWFQNCRAR 300 HKKHVSPNHS SSAPVTAVPS SRLSPPMLEE MAYSAYVPQD GTMLTALHSY MDAHQQLLDS 360 SPCYPIQ 367 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | LHX8 | 431707 | Q68G74 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Lhx8 | 16875 | O35652 | CPO | E14.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | LHX8 | 469353 | H2R2T0 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | Lhx8 | 365963 | G3V6V6 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | lhx8a | A5PMV8 | Danio rerio | Prediction | More>> |
| Gene symbol | Significant Variants/SNPS | Methods | PubMed ID |
|---|---|---|---|
| LHX8 | haplotype combination rs17565565C/rs6593568A | Genotyping | 21462296 |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IBA |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | IBA |
| GO:0046872 | metal ion binding | IEA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0007611 | learning or memory | IMP |
| GO:0008585 | female gonad development | IMP |
| GO:0021879 | forebrain neuron differentiation | IMP |
| GO:0021884 | forebrain neuron development | IGI |
| GO:0021884 | forebrain neuron development | IBA |
| GO:0030182 | neuron differentiation | IBA |
| GO:0042475 | odontogenesis of dentin-containing tooth | IMP |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | IBA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0001674 | female germ cell nucleus | IDA |
| GO:0005634 | nucleus | IBA |
| Reactome ID | Reactome Term | Evidence |
|---|