| Tag | Content |
|---|---|
| Uniprot ID | A8WGP7 |
| Entrez ID | 116991 |
| Genbank protein ID | AAI54795.1 |
| Genbank nucleotide ID | NM_001110402.1 |
| Ensembl protein ID | ENSDARP00000004687; ENSDARP00000148007; ENSDARP00000108630; |
| Ensembl nucleotide ID | ENSDARG00000110018; ENSDARG00000019838; |
| Gene name | UDP-glucose 6-dehydrogenase |
| Gene symbol | ugdh |
| Organism | Danio rerio |
| NCBI taxa ID | 7955 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate. |
| Sequence | MFQIKKICCI GAGYVGGPTC SVIASMCPEI TVTVVDVNES RIKAWNSDTL PIYEPGLNEV 60 VLSCRGKNLF FSTDIDSAIK EADLVFISVN TPTKTYGMGK GRAADLKFIE ACARRIVEVS 120 DGYKIVTEKS TVPVRAAESI RRIFDANTKP SLNLQVLSNP EFLAEGTAVK DLKEPDRVLI 180 GGDETPEGQR AISALCAVYE HWVPKTRIIT TNTWSSELSK LAANAFLAQR ISSINSISAL 240 CESTGADVEE VARAIGMDQR IGSKFLKASV GFGGSCFQKD VLNLVYLCEA LNLPEVASYW 300 QQVIDMNEYQ RKRFACRIID CLFNTVTGKK IALLGFSFKK DTGDTRESSS IYISKYLMDE 360 GAKLHIYDPK VLKEQIIQDL SQPGISGDNP ERVSDLVTVT VDPYEACESA HALVICTEWD 420 MFKDLDYEKI YHKMLKPAFI FDGRRVLDHL HTQLQNVGFQ IETIGKKVMT RIPFTTSGGV 480 PRITEPPVKK SKA 493 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | UGDH | 281564 | P12378 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | UGDH | 479107 | E2R311 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | UGDH | 102171772 | A0A452G134 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | UGDH | 7358 | O60701 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Ugdh | 22235 | O70475 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | UGDH | 471171 | H2QPC9 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | UGDH | 100627727 | I3LIM2 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | Ugdh | G3V6C4 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | ugdh | 116991 | A8WGP7 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005829 | cytosol |
| GO:0005634 | nucleus |
| GO:0051287 | NAD binding |
| GO:0003979 | UDP-glucose 6-dehydrogenase activity |
| GO:0003190 | atrioventricular valve formation |
| GO:0005975 | carbohydrate metabolic process |
| GO:0007368 | determination of left/right symmetry |
| GO:0006024 | glycosaminoglycan biosynthetic process |
| GO:0007507 | heart development |
| GO:0003188 | heart valve formation |
| GO:0090263 | positive regulation of canonical Wnt signaling pathway |
| GO:0045880 | positive regulation of smoothened signaling pathway |
| GO:0006065 | UDP-glucuronate biosynthetic process |