| Tag | Content |
|---|---|
| Uniprot ID | O70475 |
| Entrez ID | 22235 |
| Genbank protein ID | AAC36096.1; AAH06749.1; |
| Genbank nucleotide ID | NM_009466.2; XM_006503862.3; |
| Ensembl protein ID | ENSMUSP00000031103 |
| Ensembl nucleotide ID | ENSMUSG00000029201 |
| Gene name | UDP-glucose 6-dehydrogenase |
| Gene symbol | Ugdh |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 22745308 |
| Functional description | Catalyzes the formation of UDP-alpha-D-glucuronate, a constituent of complex glycosaminoglycans (PubMed:9737970). Required for the biosynthesis of chondroitin sulfate and heparan sulfate. Required for embryonic development via its role in the biosynthesis of glycosaminoglycans (PubMed:14505572). |
| Sequence | MVEIKKICCI GAGYVGGPTC SVIAHMCPEI RVTVVDVNEA RINAWNSPTL PIYEPGLKEV 60 VESCRGKNLF FSTNIDDAIR EADLVFISVN TPTKTYGMGK GRAADLKYIE ACARRIVQNS 120 NGYKIVTEKS TVPVRAAESI RRIFDANTKP NLNLQVLSNP EFLAEGTAIK DLKNPDRVLI 180 GGDETPEGQK AVRALCAVYE HWVPKEKILT TNTWSSELSK LAANAFLAQR ISSINSISAL 240 CEATGADVEE VATAIGMDQR IGNKFLKASV GFGGSCFQKD VLNLVYLCEA LNLPEVARYW 300 QQVIDMNDYQ RRRFASRIID SLFNTVTDKK IAILGFAFKK DTGDTRESSS IYISKYLMDE 360 GAHLHIYDPK VPREQIVVDL SHPGVSADDQ VSRLVTISKD PYEACDGAHA LVICTEWDMF 420 KELDYERIHK KMLKPAFIFD GRRVLDGLHS ELQTIGFQIE TIGKKVSSKR IPYTPGEIPK 480 FSLQDPPNKK PKV 493 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | UGDH | 281564 | P12378 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | UGDH | 479107 | E2R311 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | UGDH | 102171772 | A0A452G134 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | UGDH | 7358 | O60701 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Ugdh | 22235 | O70475 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | UGDH | 471171 | H2QPC9 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | UGDH | 100627727 | I3LIM2 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | Ugdh | G3V6C4 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | ugdh | 116991 | A8WGP7 | Danio rerio | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0003979 | UDP-glucose 6-dehydrogenase activity | ISO |
| GO:0003979 | UDP-glucose 6-dehydrogenase activity | IDA |
| GO:0051287 | NAD binding | IEA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0001702 | gastrulation with mouth forming second | IMP |
| GO:0005975 | carbohydrate metabolic process | IEA |
| GO:0006024 | glycosaminoglycan biosynthetic process | IBA |
| GO:0006065 | UDP-glucuronate biosynthetic process | ISS |
| GO:0006065 | UDP-glucuronate biosynthetic process | IEA |
| GO:0006065 | UDP-glucuronate biosynthetic process | ISO |
| GO:0015012 | heparan sulfate proteoglycan biosynthetic process | IMP |
| GO:0030206 | chondroitin sulfate biosynthetic process | IMP |
| GO:0034214 | protein hexamerization | ISS |
| GO:0034214 | protein hexamerization | ISO |
| GO:0055114 | oxidation-reduction process | IEA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005634 | nucleus | IBA |
| GO:0005654 | nucleoplasm | ISO |
| GO:0005829 | cytosol | ISO |
| GO:0005829 | cytosol | IBA |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-1430728 | Metabolism | IEA |
| R-MMU-156580 | Phase II - Conjugation of compounds | IEA |
| R-MMU-156588 | Glucuronidation | IEA |
| R-MMU-173599 | Formation of the active cofactor, UDP-glucuronate | IEA |
| R-MMU-211859 | Biological oxidations | IEA |