Gene: cdk20

Basic information

Tag Content
Uniprot ID A8WIP6; Q5PRE2;
Entrez ID 494112
Genbank protein ID CAP19557.1; AAH86697.1;
Genbank nucleotide ID XM_005166689.3; NM_001008655.1;
Ensembl protein ID ENSDARP00000113146
Ensembl nucleotide ID ENSDARG00000003867
Gene name Cyclin-dependent kinase 20
Gene symbol cdk20
Organism Danio rerio
NCBI taxa ID 7955
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description Involved in cell growth. Activates cdk2, a kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160' (By similarity). Required for high-level Shh responses in the developing neural tube. Together with tbc1d32, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing gli2 to be properly activated in response to SHH signaling.
Sequence
MDQYSILGRI GEGAHGIVFK AKHIETGETV ALKKVALRRL EDGIPNQALR EIKALQEIED 60
NQYVVKLKDV FPHGTGFVLV FEYMLSDLSE VIRNSQRPLT ASQVKSYMMM LLKGVAFCHE 120
NSIMHRDLKP ANLLISSTGH LKIADFGLAR LFSNEGDRLY SHQVATRWYR APELLYGARK 180
YDEGVDLWAV GCIFGELLNN SPLFPGENDI EQLCCVLRVL GTPNQKVWPE ITELPDYNKI 240
TFKENPPIPL EEIVPDTSPQ AVDLLKKFLV YPSKQRISAR QALLHPYFFT DPLPAHHSEL 300
PIPQRGGKHS RQRMQPPHEF TVDRPLHESV VDPSLIQKHA MSCS 344

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologCDK20510920A6H7E6Bos taurusPredictionMore>>
1:1 orthologCDK20476355F1PPV7Canis lupus familiarisPredictionMore>>
1:1 orthologCDK20102173001A0A452EEB7Capra hircusPredictionMore>>
1:1 orthologCDK2023552Q8IZL9Homo sapiensPredictionMore>>
1:1 orthologCdk20105278Q9JHU3CPOMus musculusPublicationMore>>
1:1 orthologCDK20K7CGC1Pan troglodytesPredictionMore>>
1:1 orthologCDK20A0A5G2RB04Sus scrofaPredictionMore>>
1:1 orthologCDK20G1STR2Oryctolagus cuniculusPredictionMore>>
1:1 orthologCdk20364666Q4KM34Rattus norvegicusPredictionMore>>
1:1 orthologcdk20494112A8WIP6Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005929 cilium
GO:0005737 cytoplasm
GO:0005634 nucleus
GO:0005524 ATP binding
GO:0004693 cyclin-dependent protein serine/threonine kinase activity
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:0007049 cell cycle
GO:0051301 cell division
GO:0060271 cilium assembly
GO:0007275 multicellular organism development
GO:0006468 protein phosphorylation

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0067 ATP-binding
KW-0131 Cell cycle
KW-0132 Cell division
KW-0966 Cell projection
KW-0969 Cilium
KW-0963 Cytoplasm
KW-0217 Developmental protein
KW-0418 Kinase
KW-0547 Nucleotide-binding
KW-0539 Nucleus
KW-1185 Reference proteome
KW-0723 Serine/threonine-protein kinase
KW-0808 Transferase

Interpro

InterPro ID InterPro Term
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS

PROSITE

PROSITE ID PROSITE Term
PS00107 PROTEIN_KINASE_ATP
PS50011 PROTEIN_KINASE_DOM
PS00108 PROTEIN_KINASE_ST

Pfam

Pfam ID Pfam Term
PF00069 Pkinase