| Tag | Content |
|---|---|
| Uniprot ID | A8WIP6; Q5PRE2; |
| Entrez ID | 494112 |
| Genbank protein ID | CAP19557.1; AAH86697.1; |
| Genbank nucleotide ID | XM_005166689.3; NM_001008655.1; |
| Ensembl protein ID | ENSDARP00000113146 |
| Ensembl nucleotide ID | ENSDARG00000003867 |
| Gene name | Cyclin-dependent kinase 20 |
| Gene symbol | cdk20 |
| Organism | Danio rerio |
| NCBI taxa ID | 7955 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Involved in cell growth. Activates cdk2, a kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160' (By similarity). Required for high-level Shh responses in the developing neural tube. Together with tbc1d32, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing gli2 to be properly activated in response to SHH signaling. |
| Sequence | MDQYSILGRI GEGAHGIVFK AKHIETGETV ALKKVALRRL EDGIPNQALR EIKALQEIED 60 NQYVVKLKDV FPHGTGFVLV FEYMLSDLSE VIRNSQRPLT ASQVKSYMMM LLKGVAFCHE 120 NSIMHRDLKP ANLLISSTGH LKIADFGLAR LFSNEGDRLY SHQVATRWYR APELLYGARK 180 YDEGVDLWAV GCIFGELLNN SPLFPGENDI EQLCCVLRVL GTPNQKVWPE ITELPDYNKI 240 TFKENPPIPL EEIVPDTSPQ AVDLLKKFLV YPSKQRISAR QALLHPYFFT DPLPAHHSEL 300 PIPQRGGKHS RQRMQPPHEF TVDRPLHESV VDPSLIQKHA MSCS 344 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | CDK20 | 510920 | A6H7E6 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | CDK20 | 476355 | F1PPV7 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | CDK20 | 102173001 | A0A452EEB7 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | CDK20 | 23552 | Q8IZL9 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Cdk20 | 105278 | Q9JHU3 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | CDK20 | K7CGC1 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | CDK20 | A0A5G2RB04 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | CDK20 | G1STR2 | Oryctolagus cuniculus | Prediction | More>> | |||
| 1:1 ortholog | Cdk20 | 364666 | Q4KM34 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | cdk20 | 494112 | A8WIP6 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005929 | cilium |
| GO:0005737 | cytoplasm |
| GO:0005634 | nucleus |
| GO:0005524 | ATP binding |
| GO:0004693 | cyclin-dependent protein serine/threonine kinase activity |
| GO:0106310 | protein serine kinase activity |
| GO:0106311 | protein threonine kinase activity |
| GO:0007049 | cell cycle |
| GO:0051301 | cell division |
| GO:0060271 | cilium assembly |
| GO:0007275 | multicellular organism development |
| GO:0006468 | protein phosphorylation |
| Keyword ID | Keyword Term |
|---|---|
| KW-0067 | ATP-binding |
| KW-0131 | Cell cycle |
| KW-0132 | Cell division |
| KW-0966 | Cell projection |
| KW-0969 | Cilium |
| KW-0963 | Cytoplasm |
| KW-0217 | Developmental protein |
| KW-0418 | Kinase |
| KW-0547 | Nucleotide-binding |
| KW-0539 | Nucleus |
| KW-1185 | Reference proteome |
| KW-0723 | Serine/threonine-protein kinase |
| KW-0808 | Transferase |
| Pfam ID | Pfam Term |
|---|---|
| PF00069 | Pkinase |