| Tag | Content |
|---|---|
| Uniprot ID | Q4KM34 |
| Entrez ID | 364666 |
| Genbank protein ID | AAH98838.1 |
| Genbank nucleotide ID | NM_001025752.2 |
| Ensembl protein ID | ENSRNOP00000024466 |
| Ensembl nucleotide ID | ENSRNOG00000017991 |
| Gene name | Cyclin-dependent kinase 20 |
| Gene symbol | Cdk20 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Required for high-level Shh responses in the developing neural tube. Together with TBC1D32, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to SHH signaling. Involved in cell growth. Activates CDK2, a kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160' (By similarity). |
| Sequence | MDQYCILGRI GEGAHGIVFK AKHVETGEIV ALKKVALRRL EDGIPNQALR EIKALQEIED 60 SQYVVQLKAV FPHGAGFVLA FEFMLSDLAE VVRHAQRPLA PAQVKSYLQM LLKGVAFCHA 120 NNIVHRDLKP ANLLISASGQ LKIADFGLAR VFSPDGGRLY THQVATRWYR APELLYGARQ 180 YDQGVDLWAV GCIMGELLNG SPLFPGENDI EQLCCVLRIL GTPSPRVWPE ITELPDYNKI 240 SFKEQAPVPL EEVLPDASHQ ALDLLGQFLL YPPRQRIAAS QALLHQYFFT APLPAHPSEL 300 PIPQRPGGPT PKAHPGPPHV HDFHVDRPLE ESLLNPELIR PFIPEG 346 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | CDK20 | 510920 | A6H7E6 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | CDK20 | 476355 | F1PPV7 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | CDK20 | 102173001 | A0A452EEB7 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | CDK20 | 23552 | Q8IZL9 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Cdk20 | 105278 | Q9JHU3 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | CDK20 | K7CGC1 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | CDK20 | A0A5G2RB04 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | CDK20 | G1STR2 | Oryctolagus cuniculus | Prediction | More>> | |||
| 1:1 ortholog | Cdk20 | 364666 | Q4KM34 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | cdk20 | 494112 | A8WIP6 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005929 | cilium |
| GO:0005737 | cytoplasm |
| GO:0005654 | nucleoplasm |
| GO:0005634 | nucleus |
| GO:0005524 | ATP binding |
| GO:0004693 | cyclin-dependent protein serine/threonine kinase activity |
| GO:0007049 | cell cycle |
| GO:0051301 | cell division |
| GO:0007275 | multicellular organism development |
| GO:0006468 | protein phosphorylation |
| Keyword ID | Keyword Term |
|---|---|
| KW-0067 | ATP-binding |
| KW-0131 | Cell cycle |
| KW-0132 | Cell division |
| KW-0966 | Cell projection |
| KW-0969 | Cilium |
| KW-0963 | Cytoplasm |
| KW-0217 | Developmental protein |
| KW-0418 | Kinase |
| KW-0547 | Nucleotide-binding |
| KW-0539 | Nucleus |
| KW-1185 | Reference proteome |
| KW-0723 | Serine/threonine-protein kinase |
| KW-0808 | Transferase |
| Pfam ID | Pfam Term |
|---|---|
| PF00069 | Pkinase |